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The map label for this gene is gltT [H]

Identifier: 117921601

GI number: 117921601

Start: 3794450

End: 3795703

Strand: Direct

Name: gltT [H]

Synonym: Shewana3_3163

Alternate gene names: 117921601

Gene position: 3794450-3795703 (Clockwise)

Preceding gene: 117921595

Following gene: 117921606

Centisome position: 76.31

GC content: 49.04

Gene sequence:

>1254_bases
ATGATCCTTCAAACCATTAGCCGCATTCCTTTTTGGCAAAAAGTCCTCGCAGGCTTTATTTTAGGTGCGCTCGTTGGCGT
ACTTTTAGGTGAAACCGCCACTGTGCTTAAACCGCTTGGCGATTTGTTTATCAGCGCCATTAAGATGCTGGTTGCCCCAC
TGGTCTTCTGTGCGATTGTGGTCAGTATCACCTCACTCGGCTCTCAAACGAATCTCAAACGCTTAAGTCTTAAGACCTTA
GGCATGTTTATGCTGACTGGCACTGTTGCCTCACTGATTGGTTTAGCGGTTGGCTCGCTTATCGATATGGGCGGCACAAT
GCAACTGGCCACCACGGAAGTGCGTGAGCGCAATATTCCAGGCTTTGCGCAGGTGTTGCTCGATATGATCCCAGTCAATC
CCTTTGCCTCACTGGCGGATGGGAAAGTACTACAGATCATTGTATTTGCCGCATTAGTCGGTATTGCTATCAACAAGGTT
GGTGAGAAAGCAGAGCCACTAAAACGCACCATCGAAGCAGGTGCAGAAGTCATGTTCCAACTGACACGCATGGTGCTAAA
ACTCACCCCAATTGGCGTATTTGGTTTAATGGCTTGGGTAGTGGGTGAATATGGTTTATCGACCCTATTACCTCTAGGTA
AATTTATTGCCGCTATCTATATTGCCGCCCTTATCCATATGATTTTTGTCTACGGCGGACTGGTTAAATTTGCCGCGGGC
TTAAGCCCTGTGCAATTTTTCCGTAAGGCCATGCCGGCGCAATTAGTGGCTTTTAGTACCTCCTCAAGCTTCGGCACCCT
GCCCGCCAGTACCAGAGCGGTTGAAACCATGGGTGTTTCAAAGCGTTATAGCGCCTTCGTTATGCCACTCGGCGCCACCA
TGAACATGGATGGTTGTGGTGGTATCTACCCTGCAATTGCCGCGATTTTTATCGCTCAAATTTACGGCATTCCACTCGAT
ACCTTAGATTATGTGATGATTGCCGTCACAGCCACTGTGGCCTCAGTCGGTACCGCTGGCGTGCCAGGCAGCGCCATGGT
GATGTTAACCGTCACTTTAGGTGTGATTGGTTTACCCCTAGAAGGTATCGCCTTTATTGCCGCCATCGACCGTATTATCG
ATATGATCCGCACTGCGACCAACGTCACAGGCGACATGATGACCGCCGTGGTAATTGGCAAATCTGAAAATGAGCTTGAT
GTTGAGCAGTTCTACAGCAACGAGACTCAAACGGCTGCGATTGCCGATAATTAA

Upstream 100 bases:

>100_bases
ACCTGACTCGTCGCTTGGTATAAGTTCACTCACTTCAAGTGGATACTCATACTAGCATCTCAGGTCCACGGGCTTGTAAT
GATATATTTTTGGAAAACGC

Downstream 100 bases:

>100_bases
TCTCTCACGATAAATCATTAAGAGTTATCCAATAAAAAAGACCGCTTAGATGCGGTCTTTTTTATTATCCGTATTTCATT
TATTGCGAATAAAACATCCA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MILQTISRIPFWQKVLAGFILGALVGVLLGETATVLKPLGDLFISAIKMLVAPLVFCAIVVSITSLGSQTNLKRLSLKTL
GMFMLTGTVASLIGLAVGSLIDMGGTMQLATTEVRERNIPGFAQVLLDMIPVNPFASLADGKVLQIIVFAALVGIAINKV
GEKAEPLKRTIEAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIAAIYIAALIHMIFVYGGLVKFAAG
LSPVQFFRKAMPAQLVAFSTSSSFGTLPASTRAVETMGVSKRYSAFVMPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
TLDYVMIAVTATVASVGTAGVPGSAMVMLTVTLGVIGLPLEGIAFIAAIDRIIDMIRTATNVTGDMMTAVVIGKSENELD
VEQFYSNETQTAAIADN

Sequences:

>Translated_417_residues
MILQTISRIPFWQKVLAGFILGALVGVLLGETATVLKPLGDLFISAIKMLVAPLVFCAIVVSITSLGSQTNLKRLSLKTL
GMFMLTGTVASLIGLAVGSLIDMGGTMQLATTEVRERNIPGFAQVLLDMIPVNPFASLADGKVLQIIVFAALVGIAINKV
GEKAEPLKRTIEAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIAAIYIAALIHMIFVYGGLVKFAAG
LSPVQFFRKAMPAQLVAFSTSSSFGTLPASTRAVETMGVSKRYSAFVMPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
TLDYVMIAVTATVASVGTAGVPGSAMVMLTVTLGVIGLPLEGIAFIAAIDRIIDMIRTATNVTGDMMTAVVIGKSENELD
VEQFYSNETQTAAIADN
>Mature_417_residues
MILQTISRIPFWQKVLAGFILGALVGVLLGETATVLKPLGDLFISAIKMLVAPLVFCAIVVSITSLGSQTNLKRLSLKTL
GMFMLTGTVASLIGLAVGSLIDMGGTMQLATTEVRERNIPGFAQVLLDMIPVNPFASLADGKVLQIIVFAALVGIAINKV
GEKAEPLKRTIEAGAEVMFQLTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIAAIYIAALIHMIFVYGGLVKFAAG
LSPVQFFRKAMPAQLVAFSTSSSFGTLPASTRAVETMGVSKRYSAFVMPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLD
TLDYVMIAVTATVASVGTAGVPGSAMVMLTVTLGVIGLPLEGIAFIAAIDRIIDMIRTATNVTGDMMTAVVIGKSENELD
VEQFYSNETQTAAIADN

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=297, Percent_Identity=33.6700336700337, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=35.3383458646617, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI40254478, Length=292, Percent_Identity=34.5890410958904, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI194239697, Length=285, Percent_Identity=32.6315789473684, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI169790839, Length=266, Percent_Identity=33.8345864661654, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI223468566, Length=304, Percent_Identity=33.2236842105263, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI223468564, Length=272, Percent_Identity=33.8235294117647, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI5032093, Length=304, Percent_Identity=33.2236842105263, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI21314632, Length=413, Percent_Identity=28.5714285714286, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI301601644, Length=153, Percent_Identity=39.2156862745098, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI262359914, Length=180, Percent_Identity=31.1111111111111, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1790514, Length=420, Percent_Identity=36.6666666666667, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789947, Length=402, Percent_Identity=33.0845771144279, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=30.9644670050761, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789473, Length=369, Percent_Identity=23.3062330623306, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=459, Percent_Identity=28.9760348583878, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI71983099, Length=459, Percent_Identity=28.9760348583878, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71996953, Length=471, Percent_Identity=28.6624203821656, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17537407, Length=433, Percent_Identity=28.8683602771363, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193206505, Length=428, Percent_Identity=25, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=413, Percent_Identity=27.1186440677966, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541374, Length=401, Percent_Identity=26.1845386533666, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583025, Length=426, Percent_Identity=24.8826291079812, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17137668, Length=426, Percent_Identity=24.8826291079812, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583023, Length=426, Percent_Identity=24.8826291079812, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=27.6548672566372, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=27.6548672566372, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281360481, Length=452, Percent_Identity=27.4336283185841, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43887; Mature: 43887

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCHHHHHCCCCCCEECCCC
>Mature Secondary Structure
MILQTISRIPFWQKVLAGFILGALVGVLLGETATVLKPLGDLFISAIKMLVAPLVFCAIV
CCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSITSLGSQTNLKRLSLKTLGMFMLTGTVASLIGLAVGSLIDMGGTMQLATTEVRERNIP
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCC
GFAQVLLDMIPVNPFASLADGKVLQIIVFAALVGIAINKVGEKAEPLKRTIEAGAEVMFQ
HHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
LTRMVLKLTPIGVFGLMAWVVGEYGLSTLLPLGKFIAAIYIAALIHMIFVYGGLVKFAAG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LSPVQFFRKAMPAQLVAFSTSSSFGTLPASTRAVETMGVSKRYSAFVMPLGATMNMDGCG
CCHHHHHHHHCCHHHEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHEEECCCEECCCCCC
GIYPAIAAIFIAQIYGIPLDTLDYVMIAVTATVASVGTAGVPGSAMVMLTVTLGVIGLPL
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCH
EGIAFIAAIDRIIDMIRTATNVTGDMMTAVVIGKSENELDVEQFYSNETQTAAIADN
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCCCCHHHHHCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]