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The map label for this gene is pgi

Identifier: 117921586

GI number: 117921586

Start: 3776328

End: 3777965

Strand: Direct

Name: pgi

Synonym: Shewana3_3148

Alternate gene names: 117921586

Gene position: 3776328-3777965 (Clockwise)

Preceding gene: 117921585

Following gene: 117921587

Centisome position: 75.95

GC content: 48.53

Gene sequence:

>1638_bases
ATGACTATCTTGACCCAAAGCACAACTTGGCAAGCGTTAGCAGCGCATAGCCAGCAGATCCCGCATATGCGGGAACTCTT
TGCAAGCGATCCTGCACGCTTTAGCAATATGTCGCTTTCTACCTGTGGCTTATTTTTAGATTATTCAAAAAATAGAGCGA
CACCAGAGACACTCAACTTGCTGCTGACACTGGCGCAAGAGGCAAAGCTTGACGCTAAAATCAAGGCGATGTTTGCTGGT
GATATTATTAACACCACCGAAAAACGTGCAGTACTGCATACCGCACTGCGCAGCACCGCCGAGCAAACCATCATTGCCGA
GGGTCAAGATATCGTTCCTGAAGTACAGCAAACGCTGAACAAGATGCAGCAATTTGTCACTTCAGTTACCTCTGGACAAT
GGAAAGGTTTCACTGGTAAAACTATTACCGATATCGTCAGCATTGGCATCGGTGGCTCATTCCTTGGCCCTAAGATAGTT
TCCCAAGCATTACGCCCATATTGGATGACAGGCCTCAATTGCCATTTCGTTGCCAACGTCGATGGCACCTCGATCAGTGA
AAAACTTAAGCTGCTCGATCCTGAAACCACCCTGTTTATCATGTCGTCTAAGTCTTTTGGTACACAAGAGACGCTGACCA
ACACCTTAACGGCCAAGGCGTGGTTTTTAGCCAAAGGTGGTTCACAGTCTGATGTGGCGAAGCACTTTGTTGCCGTGACC
TCTAACGTGGCAAAAGCGACTGACTTTGGTATCGATGCCGACAATATCTTCCCGATGTGGGATTGGGTTGGTGGTCGTTA
TTCACTTTGGTCCGCCATTGGCTTACCCATCGCTTTACTCATCGGCATGGATAACTTCCGCTCCCTATTAAAGGGCGCGC
ACCAAATGGATACCCATTTTGCCAATGCGCCTCTGGCCGAAAATATGCCCGTCATCATGGGCTTATTCTCTCTGTGGTAT
GGCAATTTCTTTAATGCCCAGAGCCATGTGGTATTGACCTACGATCATTACCTACGTGGACTTCCCGCTTACTTCCAACA
ACTGGATATGGAAAGTAATGGTAAATCGGTCACGCTCAACGGTACTCATGTGGATTACAGCACGGGTCCTGTGATTTGGG
GCGGCGAAGGCACAAACGGTCAGCACGCTTACCACCAGCTGCTGCATCAAGGTACCGCATTAATCCCTGCTGATTTCATT
ATGCCGCTGCAAAGCCATAATCCTATCGGAGAGCACCATGATCAGTTAGCCTCTAACTGCTTCGGACAAACCCAAGCACT
CATGCAAGGCCGTACCTTGGATGAAGCACTGGCCGAATTGAGTAAGAGCAACTTAAGTGATGAAGAAAAGTTACTTATCG
CCAAACACAAGGTCATGCCTGGCAATAAGCCAAGCAACACGCTGTTAATGGATAAGCTGACTCCTGAAACCTTAGGCGCA
CTGATTGCGCTCTATGAGCACAGAACCTTTGTCCAAGGCGCCATTTGGGACATCAACTCCTTCGATCAATGGGGTGTTGA
ACTCGGAAAAAGCTTAGGAAATGACGTCCTCGCCCGCATCGGCGCCGAGCAAGACGCCACCGCCTTAGATGCCTCAAGCA
ATGGGTTAATTAACCTGTATCGACAGGGTAAAATCTGA

Upstream 100 bases:

>100_bases
AGTTAGCAGAAGGCATCCGTAACTTCGCCATCGACCAAGGTAAACTCGAAGTCATGCTCAAGGCAAAACTGGCAAACTAA
GTATCCTCGGAGACGATTCG

Downstream 100 bases:

>100_bases
TCGAACAAAAAGCCAGCAATCGCTGGCTTTTTTATTTTATCTTATTAATAAACCTAAAATATTCCCTCACAACTGCCTCC
ACGACTCTCGCGAAGATCAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTILTQSTTWQALAAHSQQIPHMRELFASDPARFSNMSLSTCGLFLDYSKNRATPETLNLLLTLAQEAKLDAKIKAMFAG
DIINTTEKRAVLHTALRSTAEQTIIAEGQDIVPEVQQTLNKMQQFVTSVTSGQWKGFTGKTITDIVSIGIGGSFLGPKIV
SQALRPYWMTGLNCHFVANVDGTSISEKLKLLDPETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGSQSDVAKHFVAVT
SNVAKATDFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRSLLKGAHQMDTHFANAPLAENMPVIMGLFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTHVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLQSHNPIGEHHDQLASNCFGQTQALMQGRTLDEALAELSKSNLSDEEKLLIAKHKVMPGNKPSNTLLMDKLTPETLGA
LIALYEHRTFVQGAIWDINSFDQWGVELGKSLGNDVLARIGAEQDATALDASSNGLINLYRQGKI

Sequences:

>Translated_545_residues
MTILTQSTTWQALAAHSQQIPHMRELFASDPARFSNMSLSTCGLFLDYSKNRATPETLNLLLTLAQEAKLDAKIKAMFAG
DIINTTEKRAVLHTALRSTAEQTIIAEGQDIVPEVQQTLNKMQQFVTSVTSGQWKGFTGKTITDIVSIGIGGSFLGPKIV
SQALRPYWMTGLNCHFVANVDGTSISEKLKLLDPETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGSQSDVAKHFVAVT
SNVAKATDFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRSLLKGAHQMDTHFANAPLAENMPVIMGLFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTHVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLQSHNPIGEHHDQLASNCFGQTQALMQGRTLDEALAELSKSNLSDEEKLLIAKHKVMPGNKPSNTLLMDKLTPETLGA
LIALYEHRTFVQGAIWDINSFDQWGVELGKSLGNDVLARIGAEQDATALDASSNGLINLYRQGKI
>Mature_544_residues
TILTQSTTWQALAAHSQQIPHMRELFASDPARFSNMSLSTCGLFLDYSKNRATPETLNLLLTLAQEAKLDAKIKAMFAGD
IINTTEKRAVLHTALRSTAEQTIIAEGQDIVPEVQQTLNKMQQFVTSVTSGQWKGFTGKTITDIVSIGIGGSFLGPKIVS
QALRPYWMTGLNCHFVANVDGTSISEKLKLLDPETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGSQSDVAKHFVAVTS
NVAKATDFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRSLLKGAHQMDTHFANAPLAENMPVIMGLFSLWYG
NFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTHVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIM
PLQSHNPIGEHHDQLASNCFGQTQALMQGRTLDEALAELSKSNLSDEEKLLIAKHKVMPGNKPSNTLLMDKLTPETLGAL
IALYEHRTFVQGAIWDINSFDQWGVELGKSLGNDVLARIGAEQDATALDASSNGLINLYRQGKI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=554, Percent_Identity=50.1805054151625, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI296080693, Length=554, Percent_Identity=46.5703971119134, Blast_Score=521, Evalue=1e-148,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=51.6666666666667, Blast_Score=584, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI71996708, Length=547, Percent_Identity=52.2851919561243, Blast_Score=579, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI71996703, Length=547, Percent_Identity=52.2851919561243, Blast_Score=579, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319673, Length=528, Percent_Identity=49.8106060606061, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24651916, Length=527, Percent_Identity=54.0796963946869, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24651914, Length=527, Percent_Identity=54.0796963946869, Blast_Score=585, Evalue=1e-167,
Organism=Drosophila melanogaster, GI17737445, Length=527, Percent_Identity=54.0796963946869, Blast_Score=585, Evalue=1e-167,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SHESA (A0L003)

Other databases:

- EMBL:   CP000469
- RefSeq:   YP_870778.1
- ProteinModelPortal:   A0L003
- SMR:   A0L003
- STRING:   A0L003
- GeneID:   4477742
- GenomeReviews:   CP000469_GR
- KEGG:   shn:Shewana3_3148
- NMPDR:   fig|94122.5.peg.3163
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   A0L003
- ProtClustDB:   PRK00179
- BioCyc:   SSP94122:SHEWANA3_3148-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59694; Mature: 59562

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 351-351 ACT_SITE 382-382 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILTQSTTWQALAAHSQQIPHMRELFASDPARFSNMSLSTCGLFLDYSKNRATPETLNL
CEEEECCCHHHHHHHHHHCCCHHHHHHCCCCCHHCCCCHHHHEEEEECCCCCCCHHHHHH
LLTLAQEAKLDAKIKAMFAGDIINTTEKRAVLHTALRSTAEQTIIAEGQDIVPEVQQTLN
HHHHHHHHCCCHHHHEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KMQQFVTSVTSGQWKGFTGKTITDIVSIGIGGSFLGPKIVSQALRPYWMTGLNCHFVANV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCHHHHCCCCEEEEECC
DGTSISEKLKLLDPETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGSQSDVAKHFVAVT
CCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHH
SNVAKATDFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRSLLKGAHQMDTHF
HHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANAPLAENMPVIMGLFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEE
GTHVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLQSHNPIGEHHDQLASNC
CCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
FGQTQALMQGRTLDEALAELSKSNLSDEEKLLIAKHKVMPGNKPSNTLLMDKLTPETLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHEEHHHHHCCCCCCCCCCEEEECCCHHHHHH
LIALYEHRTFVQGAIWDINSFDQWGVELGKSLGNDVLARIGAEQDATALDASSNGLINLY
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEE
RQGKI
ECCCC
>Mature Secondary Structure 
TILTQSTTWQALAAHSQQIPHMRELFASDPARFSNMSLSTCGLFLDYSKNRATPETLNL
EEEECCCHHHHHHHHHHCCCHHHHHHCCCCCHHCCCCHHHHEEEEECCCCCCCHHHHHH
LLTLAQEAKLDAKIKAMFAGDIINTTEKRAVLHTALRSTAEQTIIAEGQDIVPEVQQTLN
HHHHHHHHCCCHHHHEEECCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
KMQQFVTSVTSGQWKGFTGKTITDIVSIGIGGSFLGPKIVSQALRPYWMTGLNCHFVANV
HHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCHHHHCCCCEEEEECC
DGTSISEKLKLLDPETTLFIMSSKSFGTQETLTNTLTAKAWFLAKGGSQSDVAKHFVAVT
CCCCHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHH
SNVAKATDFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRSLLKGAHQMDTHF
HHHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANAPLAENMPVIMGLFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEE
GTHVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLQSHNPIGEHHDQLASNC
CCEEECCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHH
FGQTQALMQGRTLDEALAELSKSNLSDEEKLLIAKHKVMPGNKPSNTLLMDKLTPETLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHEEHHHHHCCCCCCCCCCEEEECCCHHHHHH
LIALYEHRTFVQGAIWDINSFDQWGVELGKSLGNDVLARIGAEQDATALDASSNGLINLY
HHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCEEEEE
RQGKI
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA