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The map label for this gene is lspA [H]

Identifier: 117921573

GI number: 117921573

Start: 3760169

End: 3760681

Strand: Reverse

Name: lspA [H]

Synonym: Shewana3_3135

Alternate gene names: 117921573

Gene position: 3760681-3760169 (Counterclockwise)

Preceding gene: 117921574

Following gene: 117921572

Centisome position: 75.63

GC content: 43.08

Gene sequence:

>513_bases
ATGCCATTAACTTGGAAAGACAGTGGCTTACGTTGGTATTGGGTAGTTGTATTGGTGTTTTTGGCCGATCAACTATCTAA
ACAATGGGTCTTAGCCAATTTTGATTTGTTCGAATCGGTGAAGTTATTACCTTTTTTTAATTTCACCTATGTACGTAACT
ATGGCGCCGCATTTAGCTTTTTAAGCGAAGCGGGCGGTTGGCAACGTTGGTTATTTACCTTAGTGGCTGTTGGTTTCAGT
ACCTTGTTGACTGTGTGGCTGCGCAAGCAATCGGCATCCCTCTGGAAGTTAAACTTGGCTTACACCTTAGTGATTGGTGG
CGCCCTAGGTAACTTAATCGATCGATTGATGCACGGTTTTGTGGTGGATTTTATCGATTTTTATTGGGGCAAGAGCCATT
ATCCCGCCTTTAATATCGCCGATTCCGCGATTTTTATCGGCGCCGTGCTGATCATTTGGGATTCGTTTTTTAACAGCAAA
TCCGAACAAGATAAAACCGAAGAGGTGAAGTAG

Upstream 100 bases:

>100_bases
AGAAGTGGGCACGATTGAGGCTCACCCAACGCTGTGCCATCGCTGCGTAACCAATATTGAAGGTGACGGCGAAGTTCGTC
TGTTTGCGTAAAGGATCTGT

Downstream 100 bases:

>100_bases
TGACTGTGACACGTTCGTTATTGTGCCATATGAATATTGTGCTTGAAGATGGTTCGACCGCCGATAGCACTAAAGCCTCG
GGTAAGCCAGCACGCCTTAA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MPLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSFLSEAGGWQRWLFTLVAVGFS
TLLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGFVVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSK
SEQDKTEEVK

Sequences:

>Translated_170_residues
MPLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSFLSEAGGWQRWLFTLVAVGFS
TLLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGFVVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSK
SEQDKTEEVK
>Mature_169_residues
PLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSFLSEAGGWQRWLFTLVAVGFST
LLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGFVVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSKS
EQDKTEEVK

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=50.609756097561, Blast_Score=170, Evalue=6e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 19631; Mature: 19500

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00855 SPASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSF
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEAGGWQRWLFTLVAVGFSTLLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSKSEQDKTEEVK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
PLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSF
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEAGGWQRWLFTLVAVGFSTLLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHH
VVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSKSEQDKTEEVK
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]