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The map label for this gene is aqpZ [H]

Identifier: 117921502

GI number: 117921502

Start: 3677237

End: 3677932

Strand: Direct

Name: aqpZ [H]

Synonym: Shewana3_3064

Alternate gene names: 117921502

Gene position: 3677237-3677932 (Clockwise)

Preceding gene: 117921500

Following gene: 117921503

Centisome position: 73.96

GC content: 53.74

Gene sequence:

>696_bases
ATGAATATGTCACAAAAAATGGCGGCAGAATTTTTGGGCACTCTGTGGCTCGTTCTCGGCGGCTGCGGCAGCGCAGTGCT
GGCGGCAGCCTTTCCGGAAGTTGGGATCGGTTTACTCGGGGTGGCGTTAGCCTTTGGTTTAACGGTTCTGACCATGGCAT
TCGCCATTGGCCATATTTCGGGCTGCCACTTAAACCCCGCCGTATCCTTTGGGCTCTGGGCTGGCGGACGTTTTCCAGCC
TCGGAACTGCTGCCTTATATCATTGCCCAAGTGGCGGGTGGTATTGTCGGCGCGGGTGTATTGTACGCCATCGCCTCAGG
GCAAGAAGGTTTTAGTCTTGCGGCAGGCTTTGCTTCTAACGGCTTTGGCGAACATTCCCCCGGCGGTTACAGCATGATGT
CGGTGCTAATCTGCGAAATCGTGATGACCTTGTTCTTCTTATTGGTGATTTTAGGTGCGACCGACGAGCGCGCACCTAAA
GGCTTTGCGCCGATTGCGATTGGTCTGTGTTTAACCCTTATACACTTGATCAGCATTCCCGTGTCAAACACCTCGGTCAA
TCCGGCTCGCAGTACCGGCCCAGCGCTGTTTGTTGGCGATTGGGCTGTATCACAACTGTGGATATTCTGGGTCGCTCCTA
TCGTAGGTGCGATTCTCGCCGGTATGATTTACCGTTATTTCAAGGCTGCTGAGTAA

Upstream 100 bases:

>100_bases
TTATTTATCTAGCTCAACTTAACCAGCAAGATAAACAAGGGTTTATGCAAAGAGCGCGAAGCGTATGTCCGCATAAATCG
TCTGAATAGGAAATCAATCA

Downstream 100 bases:

>100_bases
TTCCCCGCTAGCAACAGCGCCTTCGCGGCGTTGTTGTGCTTTTTCAAACCCCGCTCTAATGTTACCATCTTGCCAACTGG
TGAGTTTTGCTGTGCTGACG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
SELLPYIIAQVAGGIVGAGVLYAIASGQEGFSLAAGFASNGFGEHSPGGYSMMSVLICEIVMTLFFLLVILGATDERAPK
GFAPIAIGLCLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWIFWVAPIVGAILAGMIYRYFKAAE

Sequences:

>Translated_231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
SELLPYIIAQVAGGIVGAGVLYAIASGQEGFSLAAGFASNGFGEHSPGGYSMMSVLICEIVMTLFFLLVILGATDERAPK
GFAPIAIGLCLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWIFWVAPIVGAILAGMIYRYFKAAE
>Mature_231_residues
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVSFGLWAGGRFPA
SELLPYIIAQVAGGIVGAGVLYAIASGQEGFSLAAGFASNGFGEHSPGGYSMMSVLICEIVMTLFFLLVILGATDERAPK
GFAPIAIGLCLTLIHLISIPVSNTSVNPARSTGPALFVGDWAVSQLWIFWVAPIVGAILAGMIYRYFKAAE

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=233, Percent_Identity=39.0557939914163, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4502183, Length=224, Percent_Identity=37.0535714285714, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI4502179, Length=225, Percent_Identity=35.1111111111111, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4755125, Length=229, Percent_Identity=33.6244541484716, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4502181, Length=229, Percent_Identity=33.6244541484716, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI6912506, Length=220, Percent_Identity=34.5454545454545, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI86792455, Length=225, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI45446752, Length=207, Percent_Identity=35.2657004830918, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=30.7377049180328, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4826645, Length=240, Percent_Identity=28.3333333333333, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI297307120, Length=93, Percent_Identity=43.010752688172, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI297307116, Length=95, Percent_Identity=42.1052631578947, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI297307118, Length=95, Percent_Identity=42.1052631578947, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4502187, Length=247, Percent_Identity=27.1255060728745, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI22538420, Length=246, Percent_Identity=26.8292682926829, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787101, Length=224, Percent_Identity=73.2142857142857, Blast_Score=300, Evalue=5e-83,
Organism=Escherichia coli, GI1790362, Length=248, Percent_Identity=27.4193548387097, Blast_Score=77, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=233, Percent_Identity=34.3347639484979, Blast_Score=109, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17558372, Length=242, Percent_Identity=30.9917355371901, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71992966, Length=239, Percent_Identity=28.4518828451883, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=241, Percent_Identity=27.3858921161826, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531431, Length=241, Percent_Identity=27.3858921161826, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24652747, Length=218, Percent_Identity=38.0733944954128, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45551084, Length=218, Percent_Identity=38.0733944954128, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI19922038, Length=227, Percent_Identity=33.0396475770925, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24652751, Length=227, Percent_Identity=33.0396475770925, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136672, Length=191, Percent_Identity=31.9371727748691, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24762342, Length=198, Percent_Identity=32.3232323232323, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=27.5109170305677, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24762346, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762348, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI20130305, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24762344, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23826; Mature: 23826

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSFGLWAGGRFPASELLPYIIAQVAGGIVGAGVLYAIASGQEGFSLAAGFASN
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHCC
GFGEHSPGGYSMMSVLICEIVMTLFFLLVILGATDERAPKGFAPIAIGLCLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VSNTSVNPARSTGPALFVGDWAVSQLWIFWVAPIVGAILAGMIYRYFKAAE
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNMSQKMAAEFLGTLWLVLGGCGSAVLAAAFPEVGIGLLGVALAFGLTVLTMAFAIGHIS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GCHLNPAVSFGLWAGGRFPASELLPYIIAQVAGGIVGAGVLYAIASGQEGFSLAAGFASN
CCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHCC
GFGEHSPGGYSMMSVLICEIVMTLFFLLVILGATDERAPKGFAPIAIGLCLTLIHLISIP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VSNTSVNPARSTGPALFVGDWAVSQLWIFWVAPIVGAILAGMIYRYFKAAE
CCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]