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The map label for this gene is tyrA [H]

Identifier: 117921451

GI number: 117921451

Start: 3619096

End: 3620235

Strand: Reverse

Name: tyrA [H]

Synonym: Shewana3_3012

Alternate gene names: 117921451

Gene position: 3620235-3619096 (Counterclockwise)

Preceding gene: 117921452

Following gene: 117921450

Centisome position: 72.81

GC content: 49.82

Gene sequence:

>1140_bases
ATGAACGAAAAAACCACAACTGAATTAGAACACCTTCGCGGACTCATCGATGGTGTCGACCAGCAATTGCTGCATTTACT
GCGTAAACGCTTAGATTTAGTCGCGCAGGTGGGCACGGTTAAACACGCCGCAGGCCTGCCGATTTATGCGCCGCAACGTG
AAGCGGCAATGTTGGCAAAACGCCGCGAAGAAGCCAAAACCATGGGCATTGCGCCGCAACTGATTGAAGATATTTTGCGC
CGTTTGATGCGTGAGTCCTACCTCAATGAGAAGGATGTTGGCTTTAAGCAAGTGAAAAACGATCTCGGTTCGGTCGTGAT
TGTTGGTGGTAAGGGCCAGCTTGGTGGATTGTTTCAACAAATGCTGTCGCTCTCGGGTTACCAGGTCAAAGTGCTGGATA
AAGACGACTGGCAGCAAGCTGAAACCTTATTTGCCGACGCCGGATTGGTATTGGTGACTGTGCCTATCGCCATCACCTGC
GACATTATCCGTGAGAAACTGACCCAATTACCGCAGGAATGTATCTTAGCCGACTTAACCTCGATCAAGACTGAACCCAT
GAATGCCATGTTGGCCGCTCACAAAGGGCCCGTTGTCGGGTTTCATCCCATGTTTGGCCCAGATGTCGGCAGTTTGGCTA
AGCAGGTTGTAGTGGTGTGCCATGGGCGTGGAGCCGATAAATACCAATGGCTGCTGGAACAAATTGGGATTTGGGGCGCG
CGGATTGTCGAAGCAGAACCTGAACGTCACGACAATGCGATGCAGCTGGTACAGGCGATGCGTCACTTCTCGACCTTTGT
GTATGGCTTGAATCTTTGCAAAGAAGAAGCGGATATTGAAACCCTGCTGCAATTTAGCTCACCTATCTATCGCTTAGAGC
TCGCCATGGTAGGGCGTTTGTTTGCCCAAAGCCCCGAACTCTATGCCGATATTATTTTTGCCCAGCAGGATAGCCAGCAT
GCAATTGGCGATTATTTGGATAACTACCGTGAGGCATTAGAGCTATTAAAGCGGGGCGATAGGGACGCGTTTATCAGCCA
GTTCCAAACGGTTGCAAAATGGTTTGGTGATTTTGCACCGCAGTTTCAGCGTGAAAGTCGCATGATGCTGCAATCGGTCA
GTGATATGAAAACAAACTGA

Upstream 100 bases:

>100_bases
CAACCCGTTTCGATATGCTCAAAGTGGCCAATGCTTAAGAGTTAATCTTAAGAGCCGAATGTTTAAACACCTGACTTTAG
GTGTGTAGTGGACTGATAAG

Downstream 100 bases:

>100_bases
TAATGAATGAGTTAGCCAAAAAAATGCCCATCTTTGATGGGCTTTTTTTTAGGTTTTTTAGGCTGATTTTACCGTGTTAA
TTAGCAATTACTGAAGGTGA

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNEKTTTELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHAAGLPIYAPQREAAMLAKRREEAKTMGIAPQLIEDILR
RLMRESYLNEKDVGFKQVKNDLGSVVIVGGKGQLGGLFQQMLSLSGYQVKVLDKDDWQQAETLFADAGLVLVTVPIAITC
DIIREKLTQLPQECILADLTSIKTEPMNAMLAAHKGPVVGFHPMFGPDVGSLAKQVVVVCHGRGADKYQWLLEQIGIWGA
RIVEAEPERHDNAMQLVQAMRHFSTFVYGLNLCKEEADIETLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQDSQH
AIGDYLDNYREALELLKRGDRDAFISQFQTVAKWFGDFAPQFQRESRMMLQSVSDMKTN

Sequences:

>Translated_379_residues
MNEKTTTELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHAAGLPIYAPQREAAMLAKRREEAKTMGIAPQLIEDILR
RLMRESYLNEKDVGFKQVKNDLGSVVIVGGKGQLGGLFQQMLSLSGYQVKVLDKDDWQQAETLFADAGLVLVTVPIAITC
DIIREKLTQLPQECILADLTSIKTEPMNAMLAAHKGPVVGFHPMFGPDVGSLAKQVVVVCHGRGADKYQWLLEQIGIWGA
RIVEAEPERHDNAMQLVQAMRHFSTFVYGLNLCKEEADIETLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQDSQH
AIGDYLDNYREALELLKRGDRDAFISQFQTVAKWFGDFAPQFQRESRMMLQSVSDMKTN
>Mature_379_residues
MNEKTTTELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHAAGLPIYAPQREAAMLAKRREEAKTMGIAPQLIEDILR
RLMRESYLNEKDVGFKQVKNDLGSVVIVGGKGQLGGLFQQMLSLSGYQVKVLDKDDWQQAETLFADAGLVLVTVPIAITC
DIIREKLTQLPQECILADLTSIKTEPMNAMLAAHKGPVVGFHPMFGPDVGSLAKQVVVVCHGRGADKYQWLLEQIGIWGA
RIVEAEPERHDNAMQLVQAMRHFSTFVYGLNLCKEEADIETLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQQDSQH
AIGDYLDNYREALELLKRGDRDAFISQFQTVAKWFGDFAPQFQRESRMMLQSVSDMKTN

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=56.989247311828, Blast_Score=436, Evalue=1e-123,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42615; Mature: 42615

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKTTTELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHAAGLPIYAPQREAAMLAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RREEAKTMGIAPQLIEDILRRLMRESYLNEKDVGFKQVKNDLGSVVIVGGKGQLGGLFQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHH
MLSLSGYQVKVLDKDDWQQAETLFADAGLVLVTVPIAITCDIIREKLTQLPQECILADLT
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SIKTEPMNAMLAAHKGPVVGFHPMFGPDVGSLAKQVVVVCHGRGADKYQWLLEQIGIWGA
HHCCCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
RIVEAEPERHDNAMQLVQAMRHFSTFVYGLNLCKEEADIETLLQFSSPIYRLELAMVGRL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FAQSPELYADIIFAQQDSQHAIGDYLDNYREALELLKRGDRDAFISQFQTVAKWFGDFAP
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCH
QFQRESRMMLQSVSDMKTN
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNEKTTTELEHLRGLIDGVDQQLLHLLRKRLDLVAQVGTVKHAAGLPIYAPQREAAMLAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
RREEAKTMGIAPQLIEDILRRLMRESYLNEKDVGFKQVKNDLGSVVIVGGKGQLGGLFQQ
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCEEEECCCCCHHHHHHH
MLSLSGYQVKVLDKDDWQQAETLFADAGLVLVTVPIAITCDIIREKLTQLPQECILADLT
HHHCCCCEEEEECCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHH
SIKTEPMNAMLAAHKGPVVGFHPMFGPDVGSLAKQVVVVCHGRGADKYQWLLEQIGIWGA
HHCCCCHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
RIVEAEPERHDNAMQLVQAMRHFSTFVYGLNLCKEEADIETLLQFSSPIYRLELAMVGRL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
FAQSPELYADIIFAQQDSQHAIGDYLDNYREALELLKRGDRDAFISQFQTVAKWFGDFAP
HHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCH
QFQRESRMMLQSVSDMKTN
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]