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The map label for this gene is lpxD [H]

Identifier: 117921246

GI number: 117921246

Start: 3350919

End: 3351944

Strand: Reverse

Name: lpxD [H]

Synonym: Shewana3_2805

Alternate gene names: 117921246

Gene position: 3351944-3350919 (Counterclockwise)

Preceding gene: 117921247

Following gene: 117921245

Centisome position: 67.41

GC content: 48.83

Gene sequence:

>1026_bases
ATGAAAAGTGTGACTTTAAAAGAGCTAAGCCTGTTATTAGATGGCGTTGTCCAAGGTGATGAAACGTTAGTGATCAACAG
CGTTGCGACACTTGAACATGCCCAATCGGGTCAAATCTCTTTTTTAGCCAACAGCAAATACCGTGCTCAGCTTGAGTCAA
CTCAAGCGAGCGCGGTGTTATTGTCGGCTAAAGACGCGCAGGACTATTCAGGCACTGCGTTAGTCGTTAAAGACCCCTAT
GTGGGGTTTGCCCGTGTGGCACAGTTTTTAGATACCACGCCCAAGGCGGCCGTGGGTATCCATCCTTCGGCACAAATCGA
CTCTTCTGCCCAGTTAGGCGAAGGCGTAGCGATTGGTGCCAATGTGGTTATTGGCGCGAATGTGATCCTCGGCGAAAACG
TGCAGATTGGTGCGGGCTCTGTGATTGGTCAAGACTCCATCGTAGGCTCTAACACTCGTCTGTGGGCCAATGTGACCCTC
TATCATAATGTCCATTTAGGCCAAGATTGTATTATCCATTCCGGCGCCATTATTGGCTCCGACGGTTTCGGTTACGCCAA
CGAGCGTGGACAATGGATTAAAATTCCACAAACTGGTGGTGTACGTATTGGCGATCGCGTCGAAATCGGTGCGAACTCAA
CCATCGACCGTGGGGCTTTAGGTCATACCGAGATCCACAACGGTGTGATCATCGACAACCAAGTACAGGTTGCCCATAAC
GATATTATTGGTGAAAATACCGCGATCGCTGGCAGCACGACCATTGCAGGCAGTGTGACTATTGGTAAACATTGTATTAT
TGGTGGTAACTGCGCGATTGCAGGCCACTTAACCATTGCCGACGGTGTCCATCTTTCTGGCGCGACAAACGTTACAGGTA
ACATGCGTGAGCCTGGTTTGTATTCTTCTGCGACAGTGGCAATGGAAAACAGAGTGTGGCGTAAAAATACAGTTCGCTTC
CGTCAATTGGATGAACTGTTCCAACGTGTGAAAACGTTGGAAAAGAATGCAAATACACCAGAGTAA

Upstream 100 bases:

>100_bases
ATACGATTTAGTTTTACAGCGCGGTGCCGTCATTTATGTTAAGCCAAATGCTGACATCAGTGGCAAAGTGGTTGAAGCCT
TAAGCAAAGGCAAGTAATTA

Downstream 100 bases:

>100_bases
TTGCCCCAAGGCAATTTTGAGGAACTAGGTTCGTGTCTAATCAAATGAACACTATGGATATTACGGAGATCCTTAAGTAT
CTACCCCATAGATATCCATT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKSVTLKELSLLLDGVVQGDETLVINSVATLEHAQSGQISFLANSKYRAQLESTQASAVLLSAKDAQDYSGTALVVKDPY
VGFARVAQFLDTTPKAAVGIHPSAQIDSSAQLGEGVAIGANVVIGANVILGENVQIGAGSVIGQDSIVGSNTRLWANVTL
YHNVHLGQDCIIHSGAIIGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANSTIDRGALGHTEIHNGVIIDNQVQVAHN
DIIGENTAIAGSTTIAGSVTIGKHCIIGGNCAIAGHLTIADGVHLSGATNVTGNMREPGLYSSATVAMENRVWRKNTVRF
RQLDELFQRVKTLEKNANTPE

Sequences:

>Translated_341_residues
MKSVTLKELSLLLDGVVQGDETLVINSVATLEHAQSGQISFLANSKYRAQLESTQASAVLLSAKDAQDYSGTALVVKDPY
VGFARVAQFLDTTPKAAVGIHPSAQIDSSAQLGEGVAIGANVVIGANVILGENVQIGAGSVIGQDSIVGSNTRLWANVTL
YHNVHLGQDCIIHSGAIIGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANSTIDRGALGHTEIHNGVIIDNQVQVAHN
DIIGENTAIAGSTTIAGSVTIGKHCIIGGNCAIAGHLTIADGVHLSGATNVTGNMREPGLYSSATVAMENRVWRKNTVRF
RQLDELFQRVKTLEKNANTPE
>Mature_341_residues
MKSVTLKELSLLLDGVVQGDETLVINSVATLEHAQSGQISFLANSKYRAQLESTQASAVLLSAKDAQDYSGTALVVKDPY
VGFARVAQFLDTTPKAAVGIHPSAQIDSSAQLGEGVAIGANVVIGANVILGENVQIGAGSVIGQDSIVGSNTRLWANVTL
YHNVHLGQDCIIHSGAIIGSDGFGYANERGQWIKIPQTGGVRIGDRVEIGANSTIDRGALGHTEIHNGVIIDNQVQVAHN
DIIGENTAIAGSTTIAGSVTIGKHCIIGGNCAIAGHLTIADGVHLSGATNVTGNMREPGLYSSATVAMENRVWRKNTVRF
RQLDELFQRVKTLEKNANTPE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=338, Percent_Identity=52.0710059171598, Blast_Score=362, Evalue=1e-101,
Organism=Escherichia coli, GI1786378, Length=195, Percent_Identity=28.7179487179487, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 35792; Mature: 35792

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVTLKELSLLLDGVVQGDETLVINSVATLEHAQSGQISFLANSKYRAQLESTQASAVL
CCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCEEEEECCCEEEEECCCCCEEEE
LSAKDAQDYSGTALVVKDPYVGFARVAQFLDTTPKAAVGIHPSAQIDSSAQLGEGVAIGA
EEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECC
NVVIGANVILGENVQIGAGSVIGQDSIVGSNTRLWANVTLYHNVHLGQDCIIHSGAIIGS
EEEEECEEEECCCEEECCCCEECCCCEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANERGQWIKIPQTGGVRIGDRVEIGANSTIDRGALGHTEIHNGVIIDNQVQVAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCEEEEEEC
DIIGENTAIAGSTTIAGSVTIGKHCIIGGNCAIAGHLTIADGVHLSGATNVTGNMREPGL
CCCCCCCEECCCCEEEEEEEECCEEEEECCEEEEEEEEEECCEEECCCCCCCCCCCCCCC
YSSATVAMENRVWRKNTVRFRQLDELFQRVKTLEKNANTPE
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKSVTLKELSLLLDGVVQGDETLVINSVATLEHAQSGQISFLANSKYRAQLESTQASAVL
CCCCHHHHHHHHHHHHHCCCCEEEEEEEHHHHCCCCCCEEEEECCCEEEEECCCCCEEEE
LSAKDAQDYSGTALVVKDPYVGFARVAQFLDTTPKAAVGIHPSAQIDSSAQLGEGVAIGA
EEECCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCEEECC
NVVIGANVILGENVQIGAGSVIGQDSIVGSNTRLWANVTLYHNVHLGQDCIIHSGAIIGS
EEEEECEEEECCCEEECCCCEECCCCEECCCCEEEEEEEEEEEEECCCCEEEECCEEECC
DGFGYANERGQWIKIPQTGGVRIGDRVEIGANSTIDRGALGHTEIHNGVIIDNQVQVAHN
CCCCCCCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCCCCCCCCCEEECCEEEEEEC
DIIGENTAIAGSTTIAGSVTIGKHCIIGGNCAIAGHLTIADGVHLSGATNVTGNMREPGL
CCCCCCCEECCCCEEEEEEEECCEEEEECCEEEEEEEEEECCEEECCCCCCCCCCCCCCC
YSSATVAMENRVWRKNTVRFRQLDELFQRVKTLEKNANTPE
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]