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The map label for this gene is tyrR [H]

Identifier: 117921220

GI number: 117921220

Start: 3318131

End: 3319669

Strand: Reverse

Name: tyrR [H]

Synonym: Shewana3_2779

Alternate gene names: 117921220

Gene position: 3319669-3318131 (Counterclockwise)

Preceding gene: 117921221

Following gene: 117921219

Centisome position: 66.76

GC content: 51.4

Gene sequence:

>1539_bases
ATGCGCTTGGAAGTTAGCTGTCAAGATCGCGTGGGTTTAGCGAAAGACATCTTAGTCGTGTTAGAACGTTATGGCATTAA
TCTCATCGCTATCGATGCCAGTAACCAGGGCTTTCTCTACCTGCAATTTGCCGAGGTCAGTTTTGATACCTTAAGTGCCT
TGATGCCGCAGATCCGCAAAGTGGAGAGTGTTCACGATGTGCGAACTGTGTCGTTTATGCCTTCGGAGCAGGAACACTAC
GCCTTAAAAACCCTACTCAAAACCCTCCCTGACTCAGTGTTCTCCATCGACGTGAAGGCGCGCATTCGTATCGTCAACGA
GTCGGCGCTACTCAATATGGGCATGGGAGAGCACGAAGTGCTCGATGAGTCCTTAAACCATTGGGTGCAAGGATTTAACT
TCAGTCGCTGGCTCAGTGAGAGCCAAGTGTTGCCACAGGCGGCGCGGGTCAATATCGGTCAAAACGAATATCTGGCCGAA
ATGTTACCGATTTACTTACCCGATGAGGATGACAAGACCATCCTCGTGGGCGCAGTCGTATCGCTTAAATCGCCGGCGCG
GGTCGGCAAGCAATTCAATGCACTGCAAAATCAAACCGCGGGCTTTGAAAATGTGTTAGCCAGCAGCGACAAGATGAAAG
AAGTGCTGAAACAAGCTCGCCGGATGGCGCAGCTCGATGCGCCGCTATTAATCACCGGCGAGACTGGTACGGGCAAAGAG
CTTATGGCCAGAGCCAGCCATGATGCCAGCATGCGCCGCGAGAAACCTTTTATCGCTATTAACTGTGCGGCACTGCCCGA
TAGCGCCGCCGAAGAGGAACTCTTTGGCTACGTTAGCCAAGGCAAAGTCATTAAGCGCGGCTTTTTTGAAGAGGCAAAGG
GCGGCACAGTGTTTCTCGATGAAGTAGCTGAAATGTCCAAGGCGGCGCAGGTTAAACTGCTACGGTTATTACAGGATGGC
ACCTTTAGACGCATTGGTGGCGACGAAGAAGTTCGCGCCGATGTGCGGATCATCTGCTCGACCCAGAAAAACTTAGCCGA
GCTGTGCCAAACCGGTGAGTTTAGGGAAGATTTGTATTATCGCATCCATGTTCTTAGCTACCATATTCCGTCACTGCGCG
AGCGCAAAGTCGATATCATTCCGCTGACGGAGATGTTCCTCGAGCACTACAGTCAGCAACTCTCGAGCCCTGTGAGACGA
ATTTCGGCCCAATGTCGCGATCATCTCTTAACCTATGCTTGGCCGGGTAACGTGCGTCAGCTTAAGAATGCAGTCTTTAG
GGCGGTATCTATGTGGGACGGTTCGGGCGAGTTGACCGTTGAGCAACTTAAGTTGCCATCCTACGCCGAAGGTTTTGGCT
ATTTCGATAATGCCTTCGAAGGCAATCTCGATGATGCGATGAAGCAATTTGAGGCCAGCTTGCTGCGCCGCTTATATCCG
GCTTACCCCAGTACTCGCCAATTGGCGAAAAAATTAGGGGTGTCCCACACGGCCATCGCCAACAAACTCAGGGAATACAA
GATAGCCAAGCCAAAGTAA

Upstream 100 bases:

>100_bases
GAATGTCTTACGAGGCCAAGCCTAAGGGCATTAACCTCGAGATAATAGCTCTGCACGGTTTATCCCAGAATTCGAATCAA
AATAGGGAATATCAGTCATT

Downstream 100 bases:

>100_bases
TTTTGCTTTAAGCTTAGGATGTAACAGTATCGTTCCACTTTGTTGCCGACTTTTTCACCATATCGTTCTGCGAAATAGTG
ACAAGCGGCAGCAGGGTATG

Product: transcriptional regulator, TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEVSFDTLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKARIRIVNESALLNMGMGEHEVLDESLNHWVQGFNFSRWLSESQVLPQAARVNIGQNEYLAE
MLPIYLPDEDDKTILVGAVVSLKSPARVGKQFNALQNQTAGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVIKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSGELTVEQLKLPSYAEGFGYFDNAFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKPK

Sequences:

>Translated_512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEVSFDTLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKARIRIVNESALLNMGMGEHEVLDESLNHWVQGFNFSRWLSESQVLPQAARVNIGQNEYLAE
MLPIYLPDEDDKTILVGAVVSLKSPARVGKQFNALQNQTAGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVIKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSGELTVEQLKLPSYAEGFGYFDNAFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKPK
>Mature_512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEVSFDTLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDVKARIRIVNESALLNMGMGEHEVLDESLNHWVQGFNFSRWLSESQVLPQAARVNIGQNEYLAE
MLPIYLPDEDDKTILVGAVVSLKSPARVGKQFNALQNQTAGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVIKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSGELTVEQLKLPSYAEGFGYFDNAFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKPK

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=515, Percent_Identity=49.5145631067961, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1788550, Length=349, Percent_Identity=35.5300859598854, Blast_Score=217, Evalue=2e-57,
Organism=Escherichia coli, GI1788905, Length=288, Percent_Identity=41.3194444444444, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI1790437, Length=259, Percent_Identity=39.3822393822394, Blast_Score=198, Evalue=9e-52,
Organism=Escherichia coli, GI1790299, Length=327, Percent_Identity=36.3914373088685, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082117, Length=328, Percent_Identity=34.4512195121951, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1789233, Length=471, Percent_Identity=28.4501061571125, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=35.8255451713396, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI87082152, Length=250, Percent_Identity=44.4, Blast_Score=188, Evalue=9e-49,
Organism=Escherichia coli, GI1786524, Length=252, Percent_Identity=41.6666666666667, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=40.0862068965517, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1789828, Length=270, Percent_Identity=30, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI87081858, Length=393, Percent_Identity=25.9541984732824, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57706; Mature: 57706

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEVSFDTLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VESVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDVKARIRIVNESALLNMGMGEHEV
HHHHHHHHEEEECCCCHHHHHHHHHHHHCCCHHEEEEEEEEEEEECCHHHHCCCCCHHHH
LDESLNHWVQGFNFSRWLSESQVLPQAARVNIGQNEYLAEMLPIYLPDEDDKTILVGAVV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHCCEECCCCCCCEEEEEEHH
SLKSPARVGKQFNALQNQTAGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVIKRGFFEEAKGGTVFLD
HHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHCCHHHCCCCEEEHH
EVAEMSKAAQVKLLRLLQDGTFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHHH
RIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRRISAQCRDHLLTYAWPGNVRQ
EEEEEHCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSGELTVEQLKLPSYAEGFGYFDNAFEGNLDDAMKQFEASLLRRLYP
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKIAKPK
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEVSFDTLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHH
VESVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDVKARIRIVNESALLNMGMGEHEV
HHHHHHHHEEEECCCCHHHHHHHHHHHHCCCHHEEEEEEEEEEEECCHHHHCCCCCHHHH
LDESLNHWVQGFNFSRWLSESQVLPQAARVNIGQNEYLAEMLPIYLPDEDDKTILVGAVV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHCCEECCCCCCCEEEEEEHH
SLKSPARVGKQFNALQNQTAGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVIKRGFFEEAKGGTVFLD
HHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHCCHHHCCCCEEEHH
EVAEMSKAAQVKLLRLLQDGTFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHHH
RIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRRISAQCRDHLLTYAWPGNVRQ
EEEEEHCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSGELTVEQLKLPSYAEGFGYFDNAFEGNLDDAMKQFEASLLRRLYP
HHHHHHHHHHHCCCCCCEEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKIAKPK
CCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]