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The map label for this gene is purM [H]

Identifier: 117920986

GI number: 117920986

Start: 3042708

End: 3043745

Strand: Direct

Name: purM [H]

Synonym: Shewana3_2545

Alternate gene names: 117920986

Gene position: 3042708-3043745 (Clockwise)

Preceding gene: 117920983

Following gene: 117920987

Centisome position: 61.19

GC content: 48.75

Gene sequence:

>1038_bases
GTGAGCACTCCTACCCCACTGAGCTATAAAGACGCTGGCGTTGATATTGATGCTGGTAATGCACTGGTAAGTAACATTAA
AGCGGCTGTTAAACGTACCCGTCGTCCAGAGGTAATGGGCAACTTAGGTGGTTTTGGCGCATTGTGTGAATTACCCACTA
AATACAAGCAACCTGTTTTAGTGTCAGGCACCGATGGTGTTGGTACTAAATTGCGTTTAGCTATCGATTACAAAAAACAC
GACACAGTCGGTATCGACTTAGTGGCTATGTGTGTGAACGACTTGATCGTTCAAGGTGCTGAGCCGTTGTTTTTCCTCGA
TTACTACGCAACAGGCAAGCTAGATGTAGAAACAGCAACCTCTGTTGTTAACGGCATCGGCGAAGGTTGTTTCCAATCTG
GTTGTGCGTTAATCGGCGGTGAAACCGCTGAAATGCCAGGCATGTATGAAGGCGAAGATTACGACCTCGCAGGTTTCTGT
GTGGGCGTGGTTGAAAAGGCCGACATCATTGACGGGAGTAAAGTGGCTGCGGGTGATGCGCTGATCGCCTTAGCCTCAAG
CGGTCCTCATTCAAATGGCTACTCATTAGTTCGTAAAGTATTAGAAGTCAGCCAAGCGGACCCTCAACAGGATCTCAATG
GCAAGCCATTGATCCAACATCTGTTAGAACCAACCAAAATTTACGTTAAATCATTGCTCAAGCTGATCGAAGCATCAGAC
GTGCACGCAATGGCGCACATCACTGGCGGCGGTTTCTGGGAAAATATCCCCCGCGTACTGCCTGAAAACTGCAAAGCCGT
TATCCAAGGTGATTCATGGCAATGGCCTGCCGTTTTCAATTGGTTAATGGAAAACGGTAACATTGCAGAATATGAAATGT
ACCGCACCTTTAACTGTGGTGTCGGCATGATCGTTGCGCTGCCAGCCGATAAGGTCGATGCCGCACTGGCACTGCTCGCC
GCCGAAGGCGAACAAGCTTGGCTAATCGGTGCTATCGCTGCTCGCGAAGGCAATGAAGAGCAAGTGGAGATCCTGTAA

Upstream 100 bases:

>100_bases
CAAGGCGATAAATCCAAATCATGGCTTTCGACCCCTAGCACAAGCTGGTAGAATACCGCCGCATAAAAATCCAATAACGA
TGTACCCGAGAGGATCCTCC

Downstream 100 bases:

>100_bases
TGCCCCAAAGCTGTCGTGTAGTTGTATTAATTTCCGGAAATGGCAGTAACCTGCAAGCCGTTATCGACGGTTGTGACGAT
AATCTGCAGGCCGAAGTTGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASD
VHAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFNWLMENGNIAEYEMYRTFNCGVGMIVALPADKVDAALALLA
AEGEQAWLIGAIAAREGNEEQVEIL

Sequences:

>Translated_345_residues
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVLVSGTDGVGTKLRLAIDYKKH
DTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFC
VGVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASD
VHAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFNWLMENGNIAEYEMYRTFNCGVGMIVALPADKVDAALALLA
AEGEQAWLIGAIAAREGNEEQVEIL
>Mature_344_residues
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVLVSGTDGVGTKLRLAIDYKKHD
TVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETATSVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCV
GVVEKADIIDGSKVAAGDALIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASDV
HAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFNWLMENGNIAEYEMYRTFNCGVGMIVALPADKVDAALALLAA
EGEQAWLIGAIAAREGNEEQVEIL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=48, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=48, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=48, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=75.5102040816327, Blast_Score=545, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17567511, Length=348, Percent_Identity=41.9540229885057, Blast_Score=248, Evalue=4e-66,
Organism=Saccharomyces cerevisiae, GI6321203, Length=342, Percent_Identity=48.8304093567251, Blast_Score=316, Evalue=4e-87,
Organism=Drosophila melanogaster, GI24582400, Length=310, Percent_Identity=42.9032258064516, Blast_Score=236, Evalue=2e-62,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36777; Mature: 36646

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVL
CCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCHHHCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCC
VHAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFNWLMENGNIAEYEMYRTFNCG
CEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMIVALPADKVDAALALLAAEGEQAWLIGAIAAREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC
>Mature Secondary Structure 
STPTPLSYKDAGVDIDAGNALVSNIKAAVKRTRRPEVMGNLGGFGALCELPTKYKQPVL
CCCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCHHHCCCEE
VSGTDGVGTKLRLAIDYKKHDTVGIDLVAMCVNDLIVQGAEPLFFLDYYATGKLDVETAT
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEHHHHH
SVVNGIGEGCFQSGCALIGGETAEMPGMYEGEDYDLAGFCVGVVEKADIIDGSKVAAGDA
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCE
LIALASSGPHSNGYSLVRKVLEVSQADPQQDLNGKPLIQHLLEPTKIYVKSLLKLIEASD
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCC
VHAMAHITGGGFWENIPRVLPENCKAVIQGDSWQWPAVFNWLMENGNIAEYEMYRTFNCG
CEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEEECCC
VGMIVALPADKVDAALALLAAEGEQAWLIGAIAAREGNEEQVEIL
CEEEEEECCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]