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The map label for this gene is ppiB [H]

Identifier: 117920820

GI number: 117920820

Start: 2857409

End: 2857909

Strand: Direct

Name: ppiB [H]

Synonym: Shewana3_2377

Alternate gene names: 117920820

Gene position: 2857409-2857909 (Clockwise)

Preceding gene: 117920819

Following gene: 117920821

Centisome position: 57.47

GC content: 48.1

Gene sequence:

>501_bases
ATGACGATTATTTTTACAACCAACCTAGGTGATATCAGTATCGAACTCGATATGGAGCGTGCGCCCGTTACCGCCAAAAA
CTTTATCCGCTACTGCCAGGAAGGTTTTTATGAGCACACTATTTTCCATCGAGTGGTCAAAGGCTTTATGATCCAAGGCG
GTGGTTTTACCGCCAAAATGAAGGAAAAGCCCACCCACGAGCCGATTGTTAACGAAGCCAATAAAGGCCTATCGAATGTG
TTTGCCACAATTGCCATGGCCCGCACCGATGCACCGCACTCGGCAACCGCGCAGTTTTTTATCAATACGGCCAACAACGA
GTTCCTCGACCACACTGCAACCACGAACAACGGTTGGGGTTATGCGGTATTTGGTAAAGTCACCGCAGGACTCGAGGTCT
TGCTGCAAATTGAAGGCGTAAAAACCACCCGTGTTGCAGGCCATGAGGACGTGCCCCGTGAGCCGATTATTATCGAAAAA
GTGACTATTATTGAAAAATAG

Upstream 100 bases:

>100_bases
GCCACAGGGCGATAGCGAACCCCATGCAAATCCTTGGCACAAAAGCACTAAGTGAATTAGCAGCTTATCAACGAATTAAC
TCAAAAGAGCAGAAGCAAAT

Downstream 100 bases:

>100_bases
TAATTACCGTTGAAAAATAGTCATTATCGTTGAATAAGTACTTTATCTAATCGATGAATACAGTGGCATTACTTAGCTGT
GGTACAGCAATAACGCATCC

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MTIIFTTNLGDISIELDMERAPVTAKNFIRYCQEGFYEHTIFHRVVKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNV
FATIAMARTDAPHSATAQFFINTANNEFLDHTATTNNGWGYAVFGKVTAGLEVLLQIEGVKTTRVAGHEDVPREPIIIEK
VTIIEK

Sequences:

>Translated_166_residues
MTIIFTTNLGDISIELDMERAPVTAKNFIRYCQEGFYEHTIFHRVVKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNV
FATIAMARTDAPHSATAQFFINTANNEFLDHTATTNNGWGYAVFGKVTAGLEVLLQIEGVKTTRVAGHEDVPREPIIIEK
VTIIEK
>Mature_165_residues
TIIFTTNLGDISIELDMERAPVTAKNFIRYCQEGFYEHTIFHRVVKGFMIQGGGFTAKMKEKPTHEPIVNEANKGLSNVF
ATIAMARTDAPHSATAQFFINTANNEFLDHTATTNNGWGYAVFGKVTAGLEVLLQIEGVKTTRVAGHEDVPREPIIIEKV
TIIEK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=159, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI22547212, Length=159, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI7657473, Length=159, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI19557636, Length=141, Percent_Identity=35.4609929078014, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=36.1538461538462, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI5454154, Length=164, Percent_Identity=31.0975609756098, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI310110104, Length=135, Percent_Identity=34.0740740740741, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI7706339, Length=161, Percent_Identity=29.1925465838509, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI24308049, Length=172, Percent_Identity=30.8139534883721, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310129267, Length=135, Percent_Identity=32.5925925925926, Blast_Score=65, Evalue=2e-11,
Organism=Homo sapiens, GI310120620, Length=135, Percent_Identity=32.5925925925926, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=57.6687116564417, Blast_Score=200, Evalue=5e-53,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=49.3827160493827, Blast_Score=170, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71980594, Length=163, Percent_Identity=31.2883435582822, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=143, Percent_Identity=33.5664335664336, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=31.055900621118, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=32.5153374233129, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=56, Percent_Identity=48.2142857142857, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532643, Length=163, Percent_Identity=31.9018404907975, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=30.0613496932515, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=28.0487804878049, Blast_Score=77, Evalue=6e-15,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18414; Mature: 18283

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIFTTNLGDISIELDMERAPVTAKNFIRYCQEGFYEHTIFHRVVKGFMIQGGGFTAKM
CEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEEC
KEKPTHEPIVNEANKGLSNVFATIAMARTDAPHSATAQFFINTANNEFLDHTATTNNGWG
CCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCE
YAVFGKVTAGLEVLLQIEGVKTTRVAGHEDVPREPIIIEKVTIIEK
EEEECHHHHCEEEEEEECCCEEEEECCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
TIIFTTNLGDISIELDMERAPVTAKNFIRYCQEGFYEHTIFHRVVKGFMIQGGGFTAKM
EEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEEC
KEKPTHEPIVNEANKGLSNVFATIAMARTDAPHSATAQFFINTANNEFLDHTATTNNGWG
CCCCCCCCHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEECCCCCCCCCCE
YAVFGKVTAGLEVLLQIEGVKTTRVAGHEDVPREPIIIEKVTIIEK
EEEECHHHHCEEEEEEECCCEEEEECCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]