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The map label for this gene is lolE [H]

Identifier: 117920728

GI number: 117920728

Start: 2746851

End: 2748101

Strand: Reverse

Name: lolE [H]

Synonym: Shewana3_2285

Alternate gene names: 117920728

Gene position: 2748101-2746851 (Counterclockwise)

Preceding gene: 117920729

Following gene: 117920726

Centisome position: 55.27

GC content: 51.32

Gene sequence:

>1251_bases
ATGAAAGGACCATTAGCCCTCTCCATTGGTTGGCGTTTTTATCGTGCGCGCCAATCCAATAGTTTTATTAGCTTTATCTC
CTTCGCATCGACCGCGGGGATTGCGCTCGGGGTTGCGGTGCTGATTGTGGTGCTCTCGGCCATGAATGGTTTCGAGCGCG
AGTTAGAGCAGCGCTTGTTAGGCGTGATTTCCCAAGCCGATGTGGTTGGCGTGAATGAGCCGATTGCGGACTGGCGCGCC
GTTGAGCAAACCGCTATGCAGATTGAAGGCATTACGGCGGCGGCACCTTTTATTCGGATGCAAGGATTAGTGCAAAAGCC
CGGTGGTTTTCAGGGGCTTGCCGTTGTAGGAATCGACCCTGAGCAAGAGGCAAAAGTCTCGACCCTCGCGCAATTTATGT
CGAAAGAGACTTGGCAAGGCTTGAGCGAGGATGACAATCACATCGTCCTTGGCGAGAGCCTGCTGAAAAAGTTAGGCCTC
GAAGTTGGTGATACCCTCGCTCTGTATGTGCAAGATCTTGATCCAGAACATGCCGGCAGTTTACGGGCGGCCAAGAGCCA
TCGTTTTGTGGTGTCGGGTGTGTACCGTTTAGGCGGCGAGCTTGAGTTAACCACGGCGTATATTCCGATGCGCTATGCGG
CGAATATCCTGAATTTACATCAAGGTGTTACCGGAGTGCGGATCAGTGTGGCGCAGGTGTTTGATGCGCCAGCGAAAATT
CGTGAGTTGGGTTATGCCTTAAACCAGTCCGTTTATATCAGTGATTGGACGCGCACCCAAGGGCATTTATATCAAGATAT
TCAATTGGTTCGCACTATCATGTATCTCGTGTTGGTATTAGTGATTGGTGTGGCCTGTTTTAATATTGTCTCAACGCTCG
TGATGGCGGTGCGGGATAAAGCCAGTGAAATCGCTATTCTGATGACCATGGGGTTAAGCCGTCTTTCAGTGATGGGGATT
TTTATGGTGCAAGGCGCGTTAAATGGCCTTGTGGGTTGTGCCCTCGGCGGCGTGATTGGGATTGCGACCGCGATTAATCT
CAGTGGTATCGCCCGTGGCATTGAGCAGTTGCTTAGTATTCAACTCCTGTCGGCCGATGTGTATTTTGTGGATTTTCTGC
CGTCAGAGCTACATATGACGGATGCTGGTTTAGTGATTGCTACGGCATTTGTGATGAGTCTTATCGCAACTCTGTATCCC
GCGTGGAAGGCAAGCCAAATTGGCCCTGCACAGGCGTTGGCGGGTAGATAG

Upstream 100 bases:

>100_bases
CGTTTGTGGTGGTGACCCACGATCCTAAATTGGCGGCGCGGATGGACAGACAACTCACCATGAAGAATGGTTATCTGCAA
GCTGTCGCGGAACACGCCCA

Downstream 100 bases:

>100_bases
AAAGTCTTTAAGCCAACAAGTGCGTTCCAAGCAGATTAGCCAAAGCTGAATAACTAAAGCTAAAGTACGAAAGCAGCAAA
TAAAAAGGCCAGTGAATTCA

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIVVLSAMNGFERELEQRLLGVISQADVVGVNEPIADWRA
VEQTAMQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDPEQEAKVSTLAQFMSKETWQGLSEDDNHIVLGESLLKKLGL
EVGDTLALYVQDLDPEHAGSLRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVAQVFDAPAKI
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDKASEIAILMTMGLSRLSVMGI
FMVQGALNGLVGCALGGVIGIATAINLSGIARGIEQLLSIQLLSADVYFVDFLPSELHMTDAGLVIATAFVMSLIATLYP
AWKASQIGPAQALAGR

Sequences:

>Translated_416_residues
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIVVLSAMNGFERELEQRLLGVISQADVVGVNEPIADWRA
VEQTAMQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDPEQEAKVSTLAQFMSKETWQGLSEDDNHIVLGESLLKKLGL
EVGDTLALYVQDLDPEHAGSLRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVAQVFDAPAKI
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDKASEIAILMTMGLSRLSVMGI
FMVQGALNGLVGCALGGVIGIATAINLSGIARGIEQLLSIQLLSADVYFVDFLPSELHMTDAGLVIATAFVMSLIATLYP
AWKASQIGPAQALAGR
>Mature_416_residues
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIVVLSAMNGFERELEQRLLGVISQADVVGVNEPIADWRA
VEQTAMQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDPEQEAKVSTLAQFMSKETWQGLSEDDNHIVLGESLLKKLGL
EVGDTLALYVQDLDPEHAGSLRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVAQVFDAPAKI
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDKASEIAILMTMGLSRLSVMGI
FMVQGALNGLVGCALGGVIGIATAINLSGIARGIEQLLSIQLLSADVYFVDFLPSELHMTDAGLVIATAFVMSLIATLYP
AWKASQIGPAQALAGR

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=42.7884615384615, Blast_Score=327, Evalue=9e-91,
Organism=Escherichia coli, GI1787360, Length=415, Percent_Identity=30.6024096385542, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44698; Mature: 44698

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIVVLSAMNGFERELEQRLL
CCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
GVISQADVVGVNEPIADWRAVEQTAMQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDP
HHHHCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCC
EQEAKVSTLAQFMSKETWQGLSEDDNHIVLGESLLKKLGLEVGDTLALYVQDLDPEHAGS
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHCCCCCCCEEEEEEECCCCCCCCC
LRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVAQVFDAPAKI
CHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHEEHHHHHHCCHHHH
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDK
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASEIAILMTMGLSRLSVMGIFMVQGALNGLVGCALGGVIGIATAINLSGIARGIEQLLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLSADVYFVDFLPSELHMTDAGLVIATAFVMSLIATLYPAWKASQIGPAQALAGR
HHHHCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC
>Mature Secondary Structure
MKGPLALSIGWRFYRARQSNSFISFISFASTAGIALGVAVLIVVLSAMNGFERELEQRLL
CCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
GVISQADVVGVNEPIADWRAVEQTAMQIEGITAAAPFIRMQGLVQKPGGFQGLAVVGIDP
HHHHCCCEECCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCC
EQEAKVSTLAQFMSKETWQGLSEDDNHIVLGESLLKKLGLEVGDTLALYVQDLDPEHAGS
CHHHHHHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHCCCCCCCEEEEEEECCCCCCCCC
LRAAKSHRFVVSGVYRLGGELELTTAYIPMRYAANILNLHQGVTGVRISVAQVFDAPAKI
CHHHHCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHEEHHHHHHCCHHHH
RELGYALNQSVYISDWTRTQGHLYQDIQLVRTIMYLVLVLVIGVACFNIVSTLVMAVRDK
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ASEIAILMTMGLSRLSVMGIFMVQGALNGLVGCALGGVIGIATAINLSGIARGIEQLLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLLSADVYFVDFLPSELHMTDAGLVIATAFVMSLIATLYPAWKASQIGPAQALAGR
HHHHCCEEEEECCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]