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The map label for this gene is uvrB [H]

Identifier: 117920610

GI number: 117920610

Start: 2594447

End: 2596468

Strand: Reverse

Name: uvrB [H]

Synonym: Shewana3_2166

Alternate gene names: 117920610

Gene position: 2596468-2594447 (Counterclockwise)

Preceding gene: 117920623

Following gene: 117920607

Centisome position: 52.22

GC content: 51.43

Gene sequence:

>2022_bases
GTGTCAGAATCTGTTTTTCAGCTTGAATCTCAATTTGCCCCCGCAGGGGATCAGCCCACGGCCATTGCCAAGTTGGTCGA
TGGCTTAGAATCGGGCCTAGCTTGCCAAACCCTATTGGGGGTAACGGGCTCGGGCAAGACATTCACTATCGCCAATGTGA
TCGCCCAACTGGGGCGCCCAACCATTATTATGGCGCCAAACAAGACGCTGGCGGCGCAGCTTTATGGCGAGATGAAAGAG
TTTTTCCCCAATAATGCGGTGGAATACTTTGTCTCCTATTACGATTATTACCAGCCAGAAGCCTATGTGCCCGCATCGAA
CACCTTTATTGAAAAGGATGCGTCGGTTAACGCCCATATCGAGCAAATGCGACTCTCGGCCACGAAAGCACTGTTAGAGC
GTAAGGATGTCGTCTTGATTGCCTCTGTATCGGCAATTTACGGTCTGGGCGATCCCGATTCCTACATGAAGATGCTTTTG
CATCTACGCCAGGGCGATACCATGGGGCAGCGGGATATTCTTAAGCGCTTGAGTGAGTTGCAATATACTCGCAACGATCT
CGAGTTGCAGCGCGGTACTTTCCGCGCCCGTGGTGAAGTTATCGATATTTTCCCCGCCGATTCTGACCGCTACGGGATTC
GAGTCGAACTCTTTGACGATGAAATTGAACGCTTAAGCGAGTTTGACCCGTTAACGGGGCAAATTGTTAAACGTATCGCG
CGCACCACTGTTTATCCGAAAACCCACTATGTGACGCCGCGGGAAAAAATTCTCGAAGCGACCGAGTCAATTAAACAAGA
GCTGCGCGAGCGTAAGCAGTATCTGCTCGACAACAATAAGTTGATTGAAGCCCAGCGGATCCATGAGCGGGTGCAATACG
ATATTGAGATGATGGTCGAGCTGGGCTATTGCTCCGGTATTGAAAACTACTCCCGCTATCTGTCGGGTCGTGCACCGGGT
GAAGGTCCGCCAACTTTGCTCGATTATTTACCCGCCGATGGTTTGTTGATTATCGACGAGTCCCACGTCACTGTGCCGCA
AATTGGCGCCATGTATAAGGGTGACCGCTCCCGTAAAACCACGCTTGTGGAATATGGCTTCCGTTTACCCTCGGCGCTGG
ATAACCGGCCACTGAAGTTTGAAGAGTTTGAGCAATTGATGCCGCAGACCATTTATGTGTCGGCAACACCAAACCCTTAC
GAACTGGATAAGAGTGGTGGCGAGATTGTTGAGCAAGTTGTTCGGCCAACGGGTTTGCTCGATCCCGAGTTAGAAGTGCG
TCCGGTCAGCATCCAAGTGGACGATTTACTCTCCGAGGTCGCCAAACGCGTCGCCGTTAATGAGCGGGTGCTTGTCACCA
CCTTAACCAAGCGCATGTCGGAGGATTTAACCGAATACCTCGATGAGCACGGCGTCAAAGTCCGTTATTTGCATTCGGAT
ATCGATACCGTAGAGCGGGTGGAGATCATTCGCGATCTGCGCCTCGGTAAGTTTGATGTGCTGGTCGGTATCAACTTGCT
GCGTGAAGGTTTAGACATGCCAGAAGTTTCCTTAGTCTGTATTCTCGATGCGGATAAGGAAGGCTTTTTACGTTCGGAGC
GTTCGCTTATTCAGACCATAGGCCGCGCCGCGCGTAACGTCAATGGCAAGGTTATCCTCTATGCCGATAGGATCACCCAG
TCGATGGCCAAGGCGATGGGTGAAACCGAGCGTCGCCGCGAGAAACAACACGCCTACAACCTTGAGCATGGCATAGTGCC
AAAAGGCGTGGTCAAGCGCATTACTGACGTGATGGATGTGGACGATGGCAGAGATACTGAGAAGGGTTATAGCCCATCGT
CACTGGGTAAAGTGGCTGAACCTAAAGCCAAACGTTATCAAGCCGATGCGGCGCAGCTTAGCCATGATATCGACAAGTTA
GAGAAGCAAATGCATGAACATGCGCGTAACTTGGAGTTTGAACAGGCGGCAGCCCTACGTGATGAGGTGAAACGTTTACG
GGAGTTGCTGATCACAGCCTAA

Upstream 100 bases:

>100_bases
TTTAGGGCTTAATACTCCCTTTGACTTCTAAAGGAGAACTGCTGGAGCTTAAAGGATGAGTTGATTAGAATGGGGCGACT
AACCACAAGGATATGTTCGC

Downstream 100 bases:

>100_bases
CAAATTTGTGTCTTAGCTCGTTAGACGTAGGACTGCGATGCTAATCAAGCAGATACCAAGGTTCACTACTTAATAAAAAG
CCGCCAACATAACAATATGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSESVFQLESQFAPAGDQPTAIAKLVDGLESGLACQTLLGVTGSGKTFTIANVIAQLGRPTIIMAPNKTLAAQLYGEMKE
FFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYMKMLL
HLRQGDTMGQRDILKRLSELQYTRNDLELQRGTFRARGEVIDIFPADSDRYGIRVELFDDEIERLSEFDPLTGQIVKRIA
RTTVYPKTHYVTPREKILEATESIKQELRERKQYLLDNNKLIEAQRIHERVQYDIEMMVELGYCSGIENYSRYLSGRAPG
EGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPNPY
ELDKSGGEIVEQVVRPTGLLDPELEVRPVSIQVDDLLSEVAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITQ
SMAKAMGETERRREKQHAYNLEHGIVPKGVVKRITDVMDVDDGRDTEKGYSPSSLGKVAEPKAKRYQADAAQLSHDIDKL
EKQMHEHARNLEFEQAAALRDEVKRLRELLITA

Sequences:

>Translated_673_residues
MSESVFQLESQFAPAGDQPTAIAKLVDGLESGLACQTLLGVTGSGKTFTIANVIAQLGRPTIIMAPNKTLAAQLYGEMKE
FFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYMKMLL
HLRQGDTMGQRDILKRLSELQYTRNDLELQRGTFRARGEVIDIFPADSDRYGIRVELFDDEIERLSEFDPLTGQIVKRIA
RTTVYPKTHYVTPREKILEATESIKQELRERKQYLLDNNKLIEAQRIHERVQYDIEMMVELGYCSGIENYSRYLSGRAPG
EGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPNPY
ELDKSGGEIVEQVVRPTGLLDPELEVRPVSIQVDDLLSEVAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITQ
SMAKAMGETERRREKQHAYNLEHGIVPKGVVKRITDVMDVDDGRDTEKGYSPSSLGKVAEPKAKRYQADAAQLSHDIDKL
EKQMHEHARNLEFEQAAALRDEVKRLRELLITA
>Mature_672_residues
SESVFQLESQFAPAGDQPTAIAKLVDGLESGLACQTLLGVTGSGKTFTIANVIAQLGRPTIIMAPNKTLAAQLYGEMKEF
FPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHIEQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYMKMLLH
LRQGDTMGQRDILKRLSELQYTRNDLELQRGTFRARGEVIDIFPADSDRYGIRVELFDDEIERLSEFDPLTGQIVKRIAR
TTVYPKTHYVTPREKILEATESIKQELRERKQYLLDNNKLIEAQRIHERVQYDIEMMVELGYCSGIENYSRYLSGRAPGE
GPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKTTLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPNPYE
LDKSGGEIVEQVVRPTGLLDPELEVRPVSIQVDDLLSEVAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSDI
DTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTIGRAARNVNGKVILYADRITQS
MAKAMGETERRREKQHAYNLEHGIVPKGVVKRITDVMDVDDGRDTEKGYSPSSLGKVAEPKAKRYQADAAQLSHDIDKLE
KQMHEHARNLEFEQAAALRDEVKRLRELLITA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=73.3532934131736, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=22.4755700325733, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76157; Mature: 76026

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESVFQLESQFAPAGDQPTAIAKLVDGLESGLACQTLLGVTGSGKTFTIANVIAQLGRP
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYMKMLLHLRQGDTMGQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDLELQRGTFRARGEVIDIFPADSDRYGIRVELFDDEIERLSEFDPLTGQIVKRIA
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHH
RTTVYPKTHYVTPREKILEATESIKQELRERKQYLLDNNKLIEAQRIHERVQYDIEMMVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGEGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPNPYELDKSGGEIVEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
DPELEVRPVSIQVDDLLSEVAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITQSMAKAMGETERRREKQHAYNLEHGIVPKGVVKRITDVMDV
HHHHHCCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
DDGRDTEKGYSPSSLGKVAEPKAKRYQADAAQLSHDIDKLEKQMHEHARNLEFEQAAALR
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEVKRLRELLITA
HHHHHHHHHHCCC
>Mature Secondary Structure 
SESVFQLESQFAPAGDQPTAIAKLVDGLESGLACQTLLGVTGSGKTFTIANVIAQLGRP
CCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEHHHHHHHHCCC
TIIMAPNKTLAAQLYGEMKEFFPNNAVEYFVSYYDYYQPEAYVPASNTFIEKDASVNAHI
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEECCCCCCEECCCCCCHHHH
EQMRLSATKALLERKDVVLIASVSAIYGLGDPDSYMKMLLHLRQGDTMGQRDILKRLSEL
HHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
QYTRNDLELQRGTFRARGEVIDIFPADSDRYGIRVELFDDEIERLSEFDPLTGQIVKRIA
HHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHCCCHHHHHHHHHH
RTTVYPKTHYVTPREKILEATESIKQELRERKQYLLDNNKLIEAQRIHERVQYDIEMMVE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LGYCSGIENYSRYLSGRAPGEGPPTLLDYLPADGLLIIDESHVTVPQIGAMYKGDRSRKT
HHHHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHCCCCCCCH
TLVEYGFRLPSALDNRPLKFEEFEQLMPQTIYVSATPNPYELDKSGGEIVEQVVRPTGLL
HHHHHCCCCCHHHCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
DPELEVRPVSIQVDDLLSEVAKRVAVNERVLVTTLTKRMSEDLTEYLDEHGVKVRYLHSD
CCCCCEEEEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
IDTVERVEIIRDLRLGKFDVLVGINLLREGLDMPEVSLVCILDADKEGFLRSERSLIQTI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHH
GRAARNVNGKVILYADRITQSMAKAMGETERRREKQHAYNLEHGIVPKGVVKRITDVMDV
HHHHHCCCCCEEEEHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCC
DDGRDTEKGYSPSSLGKVAEPKAKRYQADAAQLSHDIDKLEKQMHEHARNLEFEQAAALR
CCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEVKRLRELLITA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA