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The map label for this gene is fadE [H]

Identifier: 117920598

GI number: 117920598

Start: 2580903

End: 2583182

Strand: Reverse

Name: fadE [H]

Synonym: Shewana3_2154

Alternate gene names: 117920598

Gene position: 2583182-2580903 (Counterclockwise)

Preceding gene: 117920599

Following gene: 117920595

Centisome position: 51.95

GC content: 49.08

Gene sequence:

>2280_bases
ATGTTGACGATTATAATTATTGCCCTGATTGCGATTATTGCGCTGTTTGCAGTAAAGAGCCTTCGGATGCAATTTATCAC
CCAGCCTGTGTTTCATTTCTTTAAAAAAGTATTACCGCCATTATCCGATACCGAGCGCGAAGCGATGGAAGCGGGTGATG
TGTGGTGGGAAGGCGAGTTATTCCGTGGTAACCCAAACTGGAATACCCTGCACAGCTACGGTAAACCAACCCTGACGGCT
GAAGAGAAAGACTTTATCGATAATCAGGTGATGACCGCCCTGAAGATGATCGATGATTTCGACATTGTGCATAATCGTAA
GGATTTGCCACCAGAGCTGTGGGACTACTTTAAGAAAGAAGGCTTTTTTGCGCTGATCATCCCGAAAAAGTTTGGTGGTC
GTGCGTTTTCTGCCTACGCCAACTCGACGATTGTGAGTAAATTAGCCAGCCGCAGTGTGAGTGCTGCGGTCACTGTGATG
GTGCCAAACTCATTAGGCCCAGGTGAGCTTTTGACTCATTATGGTACCAAAGAGCAAAAGGAGCGCTGGTTACCTGCATT
AGCTAAGGGTGATGAGATCCCATGTTTTGCATTAACTGGCCCTGAAGCCGGTAGTGATGCGGGCGCTATCCCCGATGTGG
GTATTGTTTGCCGTGGTGAGTTTAACGGTGAAGAAGTTTTAGGCCTGAAATTAACCTGGGACAAGCGTTATATCACCCTC
GCACCTGTGGCAACCGTATTAGGTTTAGCCTTCCAGATGCGCGACCCTGATGGTTTGCTTGGCGATAAAAAGAATTTAGG
TATTACCTGCGCCTTGATCCCTACCGATCATCCTGGTGTGGTGATTGGGCGTCGTCATAATCCGCTTAACATGGCGTTTA
TGAACGGGACTACTAAGGGCGAAGAAGTCTTTATTCCGCTGGATTGGATTATCGGTGGTCCTGAGTTTGCGGGCAGAGGC
TGGCGCATGCTGGTTGAATGTTTATCGGCGGGTCGCGGTATTTCTCTGCCTGCATTGGCTACCGCTTCTGGCCATATGGC
GACCAAAACCACCACGGCTTACAGCTATGTGCGTCAGCAATTTGGTATGGCGATTGGCAACTTTGAAGGTGTGCAAGAAG
CGCTGGCGCGCATTATCGCTAATACCTATCAATTGGAAGCGGCGCGCCGTTTAACCACAACGGGTATTGATCTTAAAGTT
AAACCTTCAGTGGTGACGGCGATTGCTAAGTTCCACATGACTGAACTGGGCCGCGCTGTGATGAACGATGCGATGGATAT
TCAGTCGGGTAAGGGTATCCAATTAGGACCTAAAAACTACTTAGGCCACCCTTATATGTCGAATCCTATTTCGATTACCG
TTGAAGGGGCGAATATTTTGACGCGTTCCTTGATGATCTTTGGTCAAGGTGCGACCCGTTGCCATCCTTATGTGTTGGCT
GAAATGGAAGCCGCGGCGATGGAAAACGAGCACGATGCGCTCGAGCGTTTCGACTCGCTGTTAATGGGCCATATGGGTTA
CGCCACTCGCAACGCGTTCAGTGCCTTATTCAACGCCTTGACTGCCAGCCGTTTCGGCAGTGCGCCGGTGAGCGGCGATA
CCAAGCAATATTACAAAGACATGTCGCGCATTTCATCGGCATTAGCCTTGATGACAGATATTTCAATGCTGATCATGGGC
GGCGATTTGAAGCGTAAGGAAATGTTGTCGGCACGTATGGGAGATGTGTTAAGCCAGCTGTACTTAGGCTCAGCCACCTT
AAAACTGTTTGAAGACAATGGCCGTCAACAGGACGATTTACCCGCGGTGCGTTATGTGATGGCAAATCGCTTGCACTTAG
CAGCTAAAGCGCTTGAAGAAGTGATCCGTAACTTCCCGAACCGCCCATTTGCATGGCTGCTACGTGCACTGATTTTCCCC
ATCGGCAACCATTTCAATGCGCCTAGCGATAAAATGGCGACTGAATTGGTCTCTGGCATGTTAAAACCGAGTCCTGCTCG
TGAACGCATTACTTTCCTATGCCCAGAGTTTGAAGGCGACGTGGGTGGTATTGCAGAGGTTGAACAGGCCTTCGTGGCGC
AATATGCCTGTAAAGAGATTTACAAGAAGCTCAAGAAAGCACAACGCGCCGGTGAGTTGCCAGCCAAAGTGCCTAACTTA
GTGTTATTTGCTAAAGCGCTGGAGCAGGGCACTGTGACTCAAGATGAGCATCAAAAGCTGTTACATGCCGATAAGCTGCG
CTTAGCGGCCATCAATGTGAATGATTTTGAAGCCTTATAA

Upstream 100 bases:

>100_bases
TGGTGAGCATAACGACATCGAAGCCGTGATCCGTAAAGTGATCCCCTACATGGCTGCGGGCGTATCAGTCCCCGTGGCTT
CTTAATAAAAGGTCTTGATT

Downstream 100 bases:

>100_bases
TCTGATCGGCTAGCACGACTACAATCGTTTCTAGCCTGACAAGATATAAAAAAACCACCTCAATTGAGGTGGTTTTTGTT
TTTAAGCTTGATGACGGTTA

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: ACDH [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MLTIIIIALIAIIALFAVKSLRMQFITQPVFHFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLTA
EEKDFIDNQVMTALKMIDDFDIVHNRKDLPPELWDYFKKEGFFALIIPKKFGGRAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTKEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRGEFNGEEVLGLKLTWDKRYITL
APVATVLGLAFQMRDPDGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLNMAFMNGTTKGEEVFIPLDWIIGGPEFAGRG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRQQFGMAIGNFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKFHMTELGRAVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENEHDALERFDSLLMGHMGYATRNAFSALFNALTASRFGSAPVSGDTKQYYKDMSRISSALALMTDISMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEEVIRNFPNRPFAWLLRALIFP
IGNHFNAPSDKMATELVSGMLKPSPARERITFLCPEFEGDVGGIAEVEQAFVAQYACKEIYKKLKKAQRAGELPAKVPNL
VLFAKALEQGTVTQDEHQKLLHADKLRLAAINVNDFEAL

Sequences:

>Translated_759_residues
MLTIIIIALIAIIALFAVKSLRMQFITQPVFHFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLTA
EEKDFIDNQVMTALKMIDDFDIVHNRKDLPPELWDYFKKEGFFALIIPKKFGGRAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTKEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRGEFNGEEVLGLKLTWDKRYITL
APVATVLGLAFQMRDPDGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLNMAFMNGTTKGEEVFIPLDWIIGGPEFAGRG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRQQFGMAIGNFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKFHMTELGRAVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENEHDALERFDSLLMGHMGYATRNAFSALFNALTASRFGSAPVSGDTKQYYKDMSRISSALALMTDISMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEEVIRNFPNRPFAWLLRALIFP
IGNHFNAPSDKMATELVSGMLKPSPARERITFLCPEFEGDVGGIAEVEQAFVAQYACKEIYKKLKKAQRAGELPAKVPNL
VLFAKALEQGTVTQDEHQKLLHADKLRLAAINVNDFEAL
>Mature_759_residues
MLTIIIIALIAIIALFAVKSLRMQFITQPVFHFFKKVLPPLSDTEREAMEAGDVWWEGELFRGNPNWNTLHSYGKPTLTA
EEKDFIDNQVMTALKMIDDFDIVHNRKDLPPELWDYFKKEGFFALIIPKKFGGRAFSAYANSTIVSKLASRSVSAAVTVM
VPNSLGPGELLTHYGTKEQKERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRGEFNGEEVLGLKLTWDKRYITL
APVATVLGLAFQMRDPDGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLNMAFMNGTTKGEEVFIPLDWIIGGPEFAGRG
WRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRQQFGMAIGNFEGVQEALARIIANTYQLEAARRLTTTGIDLKV
KPSVVTAIAKFHMTELGRAVMNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
EMEAAAMENEHDALERFDSLLMGHMGYATRNAFSALFNALTASRFGSAPVSGDTKQYYKDMSRISSALALMTDISMLIMG
GDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDLPAVRYVMANRLHLAAKALEEVIRNFPNRPFAWLLRALIFP
IGNHFNAPSDKMATELVSGMLKPSPARERITFLCPEFEGDVGGIAEVEQAFVAQYACKEIYKKLKKAQRAGELPAKVPNL
VLFAKALEQGTVTQDEHQKLLHADKLRLAAINVNDFEAL

Specific function: Catalyzes the dehydrogenation of acyl-CoA [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=320, Percent_Identity=30.9375, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI21361497, Length=496, Percent_Identity=25.8064516129032, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI4501859, Length=408, Percent_Identity=28.1862745098039, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI4557235, Length=391, Percent_Identity=24.5524296675192, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI76496475, Length=391, Percent_Identity=24.5524296675192, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI7669494, Length=392, Percent_Identity=23.469387755102, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4503943, Length=394, Percent_Identity=24.1116751269036, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081702, Length=759, Percent_Identity=51.5151515151515, Blast_Score=790, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985184, Length=383, Percent_Identity=25.3263707571802, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985192, Length=364, Percent_Identity=25, Blast_Score=94, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17508101, Length=283, Percent_Identity=30.0353356890459, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17506239, Length=282, Percent_Identity=28.0141843971631, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=330, Percent_Identity=26.6666666666667, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=248, Percent_Identity=27.4193548387097, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=330, Percent_Identity=26.0606060606061, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=341, Percent_Identity=24.633431085044, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71982178, Length=248, Percent_Identity=29.0322580645161, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=26.3565891472868, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21356377, Length=358, Percent_Identity=26.2569832402235, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666513, Length=343, Percent_Identity=25.9475218658892, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24660351, Length=328, Percent_Identity=25.9146341463415, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- InterPro:   IPR015396 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; PF09317 DUF1974 [H]

EC number: NA

Molecular weight: Translated: 83501; Mature: 83501

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIIIIALIAIIALFAVKSLRMQFITQPVFHFFKKVLPPLSDTEREAMEAGDVWWEGEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEECCEE
FRGNPNWNTLHSYGKPTLTAEEKDFIDNQVMTALKMIDDFDIVHNRKDLPPELWDYFKKE
EECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GFFALIIPKKFGGRAFSAYANSTIVSKLASRSVSAAVTVMVPNSLGPGELLTHYGTKEQK
CCEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCHHHH
ERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRGEFNGEEVLGLKLTWDKRYITL
HHHCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEH
APVATVLGLAFQMRDPDGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLNMAFMNGTTKG
HHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCCC
EEVFIPLDWIIGGPEFAGRGWRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRQQ
CEEEEEEHEEECCHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEHHHHHHHHHHHH
FGMAIGNFEGVQEALARIIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKFHMTELGRAV
HCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHH
MNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
HHHHHHCCCCCCCEECCHHCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCHHHH
EMEAAAMENEHDALERFDSLLMGHMGYATRNAFSALFNALTASRFGSAPVSGDTKQYYKD
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MSRISSALALMTDISMLIMGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDL
HHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCH
PAVRYVMANRLHLAAKALEEVIRNFPNRPFAWLLRALIFPIGNHFNAPSDKMATELVSGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LKPSPARERITFLCPEFEGDVGGIAEVEQAFVAQYACKEIYKKLKKAQRAGELPAKVPNL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLFAKALEQGTVTQDEHQKLLHADKLRLAAINVNDFEAL
HHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCC
>Mature Secondary Structure
MLTIIIIALIAIIALFAVKSLRMQFITQPVFHFFKKVLPPLSDTEREAMEAGDVWWEGEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEECCEE
FRGNPNWNTLHSYGKPTLTAEEKDFIDNQVMTALKMIDDFDIVHNRKDLPPELWDYFKKE
EECCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHC
GFFALIIPKKFGGRAFSAYANSTIVSKLASRSVSAAVTVMVPNSLGPGELLTHYGTKEQK
CCEEEEEECCCCCCEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHCCCHHHH
ERWLPALAKGDEIPCFALTGPEAGSDAGAIPDVGIVCRGEFNGEEVLGLKLTWDKRYITL
HHHCHHHCCCCCCCEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCEEEH
APVATVLGLAFQMRDPDGLLGDKKNLGITCALIPTDHPGVVIGRRHNPLNMAFMNGTTKG
HHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEECCCCCC
EEVFIPLDWIIGGPEFAGRGWRMLVECLSAGRGISLPALATASGHMATKTTTAYSYVRQQ
CEEEEEEHEEECCHHHCCCHHHHHHHHHHCCCCCCCCCEECCCCCCEEHHHHHHHHHHHH
FGMAIGNFEGVQEALARIIANTYQLEAARRLTTTGIDLKVKPSVVTAIAKFHMTELGRAV
HCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHH
MNDAMDIQSGKGIQLGPKNYLGHPYMSNPISITVEGANILTRSLMIFGQGATRCHPYVLA
HHHHHHCCCCCCCEECCHHCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCCCCHHHH
EMEAAAMENEHDALERFDSLLMGHMGYATRNAFSALFNALTASRFGSAPVSGDTKQYYKD
HHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
MSRISSALALMTDISMLIMGGDLKRKEMLSARMGDVLSQLYLGSATLKLFEDNGRQQDDL
HHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHCHHEEEEEECCCCCCCCH
PAVRYVMANRLHLAAKALEEVIRNFPNRPFAWLLRALIFPIGNHFNAPSDKMATELVSGM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LKPSPARERITFLCPEFEGDVGGIAEVEQAFVAQYACKEIYKKLKKAQRAGELPAKVPNL
CCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
VLFAKALEQGTVTQDEHQKLLHADKLRLAAINVNDFEAL
HHHHHHHHCCCCCHHHHHHHHHHCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]