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The map label for this gene is serS [H]

Identifier: 117920498

GI number: 117920498

Start: 2463087

End: 2464373

Strand: Direct

Name: serS [H]

Synonym: Shewana3_2054

Alternate gene names: 117920498

Gene position: 2463087-2464373 (Clockwise)

Preceding gene: 117920497

Following gene: 117920499

Centisome position: 49.54

GC content: 48.56

Gene sequence:

>1287_bases
ATGTTAGATCCTAAATTTTTGCGCAACGAATTAGCAGTTACCGCTGAGCGATTAGCTACCCGTGGTTTTATTTTAGATGT
CGCTCATCTCACTCAATTAGAAGAAAAACGTAAGTCACTGCAAGTGGCGACTGAAGAGTTACAAGCTTCGCGTAATGCTA
TTTCCAAGTCCATCGGACAAGCAAAAGCCCGCGGCGAAGATGTGGATGCCATCATGGCGCAGGTTGGCGATTTAGGTGCG
CAATTAGATGCGAAGAAAGTCGAGCTGGCCGCGGTACTTGAAGAAGTGAACGCGATTGCTATGTCGATGCCAAACCTGCC
AGATGAGTCTGCGCCTATCGGTGCTGATGAGACTGAAAACGTCGAAATCCGTCGTTGGGGCACACCACGCAGCTTCGATT
TCCCAGTTAAAGATCATATCGATTTAGGTGAAGGCCTAAACGGTTTAGATTTCAAAAGCGCAGTGAAAATCACTGGTTCA
CGTTTTATCGTCATGAAGGGCCAAATCGCCCGTTTAAACCGCGCATTAGGTCAGTTCATGTTAGATCTGCACACTACTGA
GCACGGTTATACCGAAGCTTACGTACCATTACTGGTTAACGAAGCAAGTTTACTGGGTACTGGCCAATTACCGAAGTTTG
GTGAAGACTTGTTCCACACTAAACCTGCGACCGAAGAAGGCCAAGGCTTAAGCCTGATCCCAACCGCAGAAGTGCCATTA
ACGAACCTAGTGCGTGACAGCATTGTCGATGAAGATGAATTGCCGATTAAGTTAACCGCGCATACCGCTTGTTTCCGCAG
TGAAGCGGGCTCATACGGTAAAGATACCCGTGGTCTTATCCGTCAGCACCAATTCGATAAAGTGGAATTAGTGCAACTGG
TTAAGCCCGAAGACTCAATGGCGGCGCTCGAAGCGCTAACTGGCCACGCTGAAACCGTGCTGCAACGCCTAGGTCTGCCA
TACCGCACAGTGATCCTGTGTACCGGTGACATGGGCTTTGGCTCAAGCAAAACCTACGATATCGAAGTGTGGTTACCAGG
TCAAAACACTTACCGTGAGATCTCTTCATGTTCAAACATGAAGGACTTCCAAGCACGTCGTATGCAAGCACGTTACCGCG
TTAAGGCAGATAACAAGCCTGCATTGCTGCACACCTTAAACGGCTCAGGCCTCGCGGTAGGTCGTACTTTAGTTGCGATT
TTAGAGAACTATCAAAATGCCGATGGTAGCGTGACCATTCCTGAAGCACTGCGCCCATACATGGGTGGACTGACTCAGAT
CGGTTAA

Upstream 100 bases:

>100_bases
GGCTTTGAATGTGGTGTTGAACCTAAGTCTATGTTTGTTTATGGTTTACTTAGGCCAACAACTGGTTTTTTCTCGCATTT
AACTATTAAGAATATATCAC

Downstream 100 bases:

>100_bases
TTGGCGTAACACAACACCATGGATAAAGGTCAACGTTATCTTCGTTGGCTTTCCTACACCGCTGTCATCGCCGTGTTTTG
CGCTGTGATGTTGGCCACCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGA
QLDAKKVELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEIRRWGTPRSFDFPVKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRPYMGGLTQIG

Sequences:

>Translated_428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGA
QLDAKKVELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEIRRWGTPRSFDFPVKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRPYMGGLTQIG
>Mature_428_residues
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGA
QLDAKKVELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEIRRWGTPRSFDFPVKDHIDLGEGLNGLDFKSAVKITGS
RFIVMKGQIARLNRALGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSVTIPEALRPYMGGLTQIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=356, Percent_Identity=35.3932584269663, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI8923421, Length=407, Percent_Identity=30.4668304668305, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=31.8452380952381, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=69.5348837209302, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=31.264367816092, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.3939393939394, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321799, Length=392, Percent_Identity=31.1224489795918, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=30.6532663316583, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24581334, Length=323, Percent_Identity=35.6037151702786, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI17737985, Length=357, Percent_Identity=34.1736694677871, Blast_Score=165, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 46870; Mature: 46870

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGAQLDAKKVELAAVLEEVNAIAMSMPNLPDESAPIGADETEN
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEIRRWGTPRSFDFPVKDHIDLGEGLNGLDFKSAVKITGSRFIVMKGQIARLNRALGQFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCCEEHHHEEECHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHH
AALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNM
HHHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSVTIPEALRPY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGLTQIG
HCCCCCCC
>Mature Secondary Structure
MLDPKFLRNELAVTAERLATRGFILDVAHLTQLEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGAQLDAKKVELAAVLEEVNAIAMSMPNLPDESAPIGADETEN
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEIRRWGTPRSFDFPVKDHIDLGEGLNGLDFKSAVKITGSRFIVMKGQIARLNRALGQFM
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHHCCCCCCCCEEHHHEEECHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVELVQLVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCHHH
AALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPGQNTYREISSCSNM
HHHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSVTIPEALRPY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHH
MGGLTQIG
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA