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The map label for this gene is thrS [H]

Identifier: 117920487

GI number: 117920487

Start: 2451269

End: 2453197

Strand: Direct

Name: thrS [H]

Synonym: Shewana3_2043

Alternate gene names: 117920487

Gene position: 2451269-2453197 (Clockwise)

Preceding gene: 117920485

Following gene: 117920488

Centisome position: 49.3

GC content: 46.81

Gene sequence:

>1929_bases
ATGCCTGTAATTACACTTCCTGATGGTAGCAAGCGCGAGTTTGCACATCCCGTATCGACTCTCGATGTTGCCGCTGATAT
CGGCCCTGGTCTTGCTAAAGCCTGTATCGCTGGTCGCGTGAATGGCGAACTAAAAGACGCTTGCGATCTGATCGAAACCG
ATGCTGAACTTTCTATTATTACCGCTAAAGACGAAGAAGGTATTGAAATCCTTCGCCATTCTTGCGCGCATTTATTAGGC
CATGCAATCAAGCAATTATGGCCACAAACCAAGATGGCGATCGGTCCTGTGATCGATAACGGCTTCTATTACGACATCGA
TCTTGAGCACAAGCTGACTCAAGAAGATATCGAAGCCCTCGAAAAACGTATGCTGGAATTGGCGAAAACCAATTACGACG
TAGTCAAACGCGTTGTGAGCTGGCAAGAAGCCCGTGATACCTTTGCCGCACGCGGTGAAGAATACAAGATCGCGATTCTG
GATGAGAACATCAGCAAAGATGCAACTCCAGCGCTGTATCATCACGAAGAATACACCGACATGTGTCGTGGTCCACACGT
GCCAAACATGCGTTTCTGCCACCATTTCAAATTGATGAGCATTGCTGGCGCTTACTGGCGCGGTAACTCTGAAAACAAGA
TGCTGCAACGTATTTACGGTACAGCATGGGCGGATAAAAAAGCCCTGAGCACCCATTTAGCCCGCCTCGAAGAAGCGGCT
AAACGTGACCACCGTAAAATAGGTAAGCAACTTGACCTCTACCATATGCAAGAAGAAGCACCAGGCATGGTGTTCTGGCA
TAACGACGGTTGGAGCATCTTCCTCGAATTAGAACGTTTCATTCGCCGTAAGTTAAATCAATACACTTACCAAGAAGTGA
AAGGTCCGTTGATGATGGACCGCGTTTTGTGGGAACGTTCCGGTCACTGGGATAAATACTCAGAAGCCATGTTCACAACC
AGCAGTGAAAACCGTGAATATGCGGTTAAGCCAATGAACTGCCCAGGCCACGTACAGATCTTCAACCAAGGCTTGAAATC
TTACCGTGATCTGCCACTGCGTATGGCGGAATTTGGTTGCTGTCACCGCAATGAGCCATCAGGTTCACTGCATGGGCTGA
TGCGCGTACGTGGTTTTACTCAAGACGATGCCCATATCTTCTGTACTGAAGATCAAGTTCAAGCAGAAGTTAGCTCTTGT
ATCCAAATGGTATACGACACTTACTCGACATTTGGCTTTGAGAACATCGTTGTAAAACTGTCAACTCGCCCTGAAAAACG
TATCGGTGACGATGCAATGTGGGACAGAGCCGAAGAAGCACTCAAGCAAGCCTTACGTGCGAACAATATCGAATTCACCA
TTTTACCGGGTGAAGGTGCCTTCTACGGTCCTAAGATTGAATTCACGCTGCACGACTGTTTAGACCGTGCATGGCAATGC
GGTACTGTGCAATTAGACTACGCATTACCGAGCCGTTTAGGTGCAACTTATGTCGCCGAAGATAACAGCCGTCAAACGCC
TGTGATGATCCATCGTGCGATTTTAGGCTCGTTGGAGCGTTTCTTAGGTATTTTGATCGAAGAATACGCAGGTCGTTTCC
CAACTTGGTTGGCTCCAATGCAAGTTGTCGTGATGAATATCACCGACAAACAGGCTGATTATGTTGAAGAAGTGGTCAAA
TTCTTCAAAGAACAAGGTATTCGCGCCTCATTTGACTTGAGGAATGAGAAAATAGGCTTTAAAATACGCGAGCACACCTT
AAGGCGTGTTCCTTATTTATTGGTCGTTGGCGATCAGGAAATGGAAAATAAGGAAGTTGCGGTGCGTACACGTGATGGCG
TTGACTTAGGTAAGATGCGAATTGAAGATTTCGCCGCTAAGATCCATCAACAAATTTCGCTCCGTAGTCTCAAATTGTTG
GAGGAATAG

Upstream 100 bases:

>100_bases
CGGCTAAGACTCCTGTACTGTCTTAACCTCGCGAGCATTCTCTTTTTACTTAATCACCATGTGGCCCTACGTGTGGGTCA
CCACTGGACAAGGATATTTC

Downstream 100 bases:

>100_bases
GTCATAAAGATCAAGAAAACAGCAGGGCGTCAGCTGGCCCCTAATAGAATCAATGAAGAAATCACAGGTGTACCAGAAGT
ACGCTTAACCGGCATTGATG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MPVITLPDGSKREFAHPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGIEILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDIDLEHKLTQEDIEALEKRMLELAKTNYDVVKRVVSWQEARDTFAARGEEYKIAIL
DENISKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLARLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTT
SSENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQVQAEVSSC
IQMVYDTYSTFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRANNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVK
FFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGVDLGKMRIEDFAAKIHQQISLRSLKLL
EE

Sequences:

>Translated_642_residues
MPVITLPDGSKREFAHPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGIEILRHSCAHLLG
HAIKQLWPQTKMAIGPVIDNGFYYDIDLEHKLTQEDIEALEKRMLELAKTNYDVVKRVVSWQEARDTFAARGEEYKIAIL
DENISKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLARLEEAA
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTT
SSENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQVQAEVSSC
IQMVYDTYSTFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRANNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVK
FFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGVDLGKMRIEDFAAKIHQQISLRSLKLL
EE
>Mature_641_residues
PVITLPDGSKREFAHPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSIITAKDEEGIEILRHSCAHLLGH
AIKQLWPQTKMAIGPVIDNGFYYDIDLEHKLTQEDIEALEKRMLELAKTNYDVVKRVVSWQEARDTFAARGEEYKIAILD
ENISKDATPALYHHEEYTDMCRGPHVPNMRFCHHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLARLEEAAK
RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMDRVLWERSGHWDKYSEAMFTTS
SENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGCCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQVQAEVSSCI
QMVYDTYSTFGFENIVVKLSTRPEKRIGDDAMWDRAEEALKQALRANNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQCG
TVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPMQVVVMNITDKQADYVEEVVKF
FKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQEMENKEVAVRTRDGVDLGKMRIEDFAAKIHQQISLRSLKLLE
E

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=618, Percent_Identity=39.9676375404531, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI38202255, Length=652, Percent_Identity=37.2699386503067, Blast_Score=437, Evalue=1e-122,
Organism=Homo sapiens, GI20070344, Length=657, Percent_Identity=35.7686453576865, Blast_Score=397, Evalue=1e-110,
Organism=Escherichia coli, GI1788013, Length=642, Percent_Identity=78.1931464174455, Blast_Score=1082, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=632, Percent_Identity=38.2911392405063, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=38.1703470031546, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=37.8980891719745, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322654, Length=437, Percent_Identity=36.6132723112128, Blast_Score=302, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24583842, Length=630, Percent_Identity=38.4126984126984, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI28574141, Length=630, Percent_Identity=38.4126984126984, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583839, Length=630, Percent_Identity=38.4126984126984, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73704; Mature: 73573

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVITLPDGSKREFAHPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSII
CCEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGIEILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDIDLEHKLTQEDIEAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLELAKTNYDVVKRVVSWQEARDTFAARGEEYKIAILDENISKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCHHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLARLEEAA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSEAMFTTSSENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCHHHHHHEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQVQAEVSSCIQMVYDTYSTFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
STRPEKRIGDDAMWDRAEEALKQALRANNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPM
CCEEECCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
QVVVMNITDKQADYVEEVVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
MENKEVAVRTRDGVDLGKMRIEDFAAKIHQQISLRSLKLLEE
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVITLPDGSKREFAHPVSTLDVAADIGPGLAKACIAGRVNGELKDACDLIETDAELSII
CEEECCCCCCHHHCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
TAKDEEGIEILRHSCAHLLGHAIKQLWPQTKMAIGPVIDNGFYYDIDLEHKLTQEDIEAL
EECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEECCEECCCEEEEEECCCCCCHHHHHHH
EKRMLELAKTNYDVVKRVVSWQEARDTFAARGEEYKIAILDENISKDATPALYHHEEYTD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCHHHHH
MCRGPHVPNMRFCHHFKLMSIAGAYWRGNSENKMLQRIYGTAWADKKALSTHLARLEEAA
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
KRDHRKIGKQLDLYHMQEEAPGMVFWHNDGWSIFLELERFIRRKLNQYTYQEVKGPLMMD
HHHHHHHCCHHHHHHHHCCCCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
RVLWERSGHWDKYSEAMFTTSSENREYAVKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGC
HHHHHCCCCCCHHHHHHEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHCC
CHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQVQAEVSSCIQMVYDTYSTFGFENIVVKL
CCCCCCCHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
STRPEKRIGDDAMWDRAEEALKQALRANNIEFTILPGEGAFYGPKIEFTLHDCLDRAWQC
CCCCCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECCEEEEEHHHHHHHHHCC
GTVQLDYALPSRLGATYVAEDNSRQTPVMIHRAILGSLERFLGILIEEYAGRFPTWLAPM
CCEEECCCCHHHCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCC
QVVVMNITDKQADYVEEVVKFFKEQGIRASFDLRNEKIGFKIREHTLRRVPYLLVVGDQE
EEEEEECCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHCCEEEEECCCC
MENKEVAVRTRDGVDLGKMRIEDFAAKIHQQISLRSLKLLEE
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA