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The map label for this gene is ampC [C]

Identifier: 117920435

GI number: 117920435

Start: 2369276

End: 2370493

Strand: Reverse

Name: ampC [C]

Synonym: Shewana3_1990

Alternate gene names: 117920435

Gene position: 2370493-2369276 (Counterclockwise)

Preceding gene: 117920440

Following gene: 117920434

Centisome position: 47.67

GC content: 47.87

Gene sequence:

>1218_bases
ATGCCAGAGTCTCTTCAGCCTGCCGTAAAAACAGCGAGGTTTTTACGCTTATCGAACCCATCACCCTTTTTAGGTTTAGT
GCTGCTTACGGCAGTGCCATTAGTGGCCAATGCTGCACCACAGGTTCAAACAAAAGCCATGCAATCCCTTGTCGATTCCG
CGATCAATCCGTTAATGAAGGAATATGGGATCCCAGGGGCTATTGTTGGGATCAGTATGAATGGTCAACAGTATTTCTTC
CCCTATGGTGTGAGCTCAAAAACCACAGAGCATCATGTCAGCAAGAATACCCTGTTCGAGATTGGTTCTATCAGCAAAAC
CTTTACCGCGACACTCGCAAACTATGCTCAAGTCGAAGGTAAGCTCACTTTGACTGATAAAGTAAGCCAATACCTGCCCG
AATTAACGGGCAGTGCCTTTGATCAGATAAATCTTATCAATCTCGCGACCCATACCGCGGGCGACTTGCCCATGCAAGTG
CCAGATAAAGTGACGAACAATGCAGAATTGATGCGTTATTTTAAAGAATGGCAACCCGCCTATGCCGCGGGAACACACCG
AAATTATGCTAATCCCAGCATTGGATTACTCGGCTTAATTGCGGCAAAACAGTTAGGGCAAAGCTTTCCAAACGCAATGG
AGCAAACCCTATTTCCACAACTGGGTATGACTCACAGCTATCTTCAAGTGCCAAGCAACAAGCTGGCCGATTACGCCCAA
GGATATAACAAGCAAGATCAGCCCGTGCGCCTGAATCCCGGTGTGTTAGCCGAGGAGGCTTACGGGATTAAAACTTCGGC
CGTGGATTTGCTGCGTTTTGTTGAAACCAATATGCAGCAACATCCTGTCCCTTCCGTACTACAGCAGGCCATAGATGCAA
CTCACGTTGGCTACTTTGATGTCGGTATGATGACCCAAGAGATGATTTGGGAGCATTATCCCTATCCTATAGCCCTCGAT
AAGCTGCTTGCTGGACATACCCAAGAAGTGGTGTTTGGCAGTGTGCCAGTGAAAGCAATCGTGCCGCCGCAAGCACCACA
GCCTGATTTATGGATAAATAAGACAGGTTCAACTGGTGGCTTTGCCGCCTATGTGGCTTATATTCCCGCGAAGAAACTGG
GCATGGTGTTACTGAGCAATAAAAATTATCCCGTTCCGCCTCGGGTGACTGTTGGCTACCAGATATTAACGGGCTTAACA
GCACTGCCAGCGAAATGA

Upstream 100 bases:

>100_bases
AGCCTAAATCATGCTAAACCTTTCATCATTATCGAGTTTCAAACGGCGCAGATTGTTAACCCGTGCCGTTCAATCATGCC
ATCATCGCGAAAGGAATTGT

Downstream 100 bases:

>100_bases
TCCCTTAGCAACCCTCATTCGATGGAAGGCAGATTCTGCTTTCCATCTTTTTAATTGTTAACTCGCATAACGCTTTACGC
CTCTATCTCTGTACTAATCT

Product: beta-lactamase

Products: NA

Alternate protein names: Cephalosporinase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPESLQPAVKTARFLRLSNPSPFLGLVLLTAVPLVANAAPQVQTKAMQSLVDSAINPLMKEYGIPGAIVGISMNGQQYFF
PYGVSSKTTEHHVSKNTLFEIGSISKTFTATLANYAQVEGKLTLTDKVSQYLPELTGSAFDQINLINLATHTAGDLPMQV
PDKVTNNAELMRYFKEWQPAYAAGTHRNYANPSIGLLGLIAAKQLGQSFPNAMEQTLFPQLGMTHSYLQVPSNKLADYAQ
GYNKQDQPVRLNPGVLAEEAYGIKTSAVDLLRFVETNMQQHPVPSVLQQAIDATHVGYFDVGMMTQEMIWEHYPYPIALD
KLLAGHTQEVVFGSVPVKAIVPPQAPQPDLWINKTGSTGGFAAYVAYIPAKKLGMVLLSNKNYPVPPRVTVGYQILTGLT
ALPAK

Sequences:

>Translated_405_residues
MPESLQPAVKTARFLRLSNPSPFLGLVLLTAVPLVANAAPQVQTKAMQSLVDSAINPLMKEYGIPGAIVGISMNGQQYFF
PYGVSSKTTEHHVSKNTLFEIGSISKTFTATLANYAQVEGKLTLTDKVSQYLPELTGSAFDQINLINLATHTAGDLPMQV
PDKVTNNAELMRYFKEWQPAYAAGTHRNYANPSIGLLGLIAAKQLGQSFPNAMEQTLFPQLGMTHSYLQVPSNKLADYAQ
GYNKQDQPVRLNPGVLAEEAYGIKTSAVDLLRFVETNMQQHPVPSVLQQAIDATHVGYFDVGMMTQEMIWEHYPYPIALD
KLLAGHTQEVVFGSVPVKAIVPPQAPQPDLWINKTGSTGGFAAYVAYIPAKKLGMVLLSNKNYPVPPRVTVGYQILTGLT
ALPAK
>Mature_404_residues
PESLQPAVKTARFLRLSNPSPFLGLVLLTAVPLVANAAPQVQTKAMQSLVDSAINPLMKEYGIPGAIVGISMNGQQYFFP
YGVSSKTTEHHVSKNTLFEIGSISKTFTATLANYAQVEGKLTLTDKVSQYLPELTGSAFDQINLINLATHTAGDLPMQVP
DKVTNNAELMRYFKEWQPAYAAGTHRNYANPSIGLLGLIAAKQLGQSFPNAMEQTLFPQLGMTHSYLQVPSNKLADYAQG
YNKQDQPVRLNPGVLAEEAYGIKTSAVDLLRFVETNMQQHPVPSVLQQAIDATHVGYFDVGMMTQEMIWEHYPYPIALDK
LLAGHTQEVVFGSVPVKAIVPPQAPQPDLWINKTGSTGGFAAYVAYIPAKKLGMVLLSNKNYPVPPRVTVGYQILTGLTA
LPAK

Specific function: This protein is a serine beta-lactamase with a substrate specificity for cephalosporins [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-C beta-lactamase family [H]

Homologues:

Organism=Escherichia coli, GI1790593, Length=372, Percent_Identity=40.0537634408602, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1786574, Length=374, Percent_Identity=21.3903743315508, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001586
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 44117; Mature: 43986

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS00336 BETA_LACTAMASE_C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESLQPAVKTARFLRLSNPSPFLGLVLLTAVPLVANAAPQVQTKAMQSLVDSAINPLMK
CCCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EYGIPGAIVGISMNGQQYFFPYGVSSKTTEHHVSKNTLFEIGSISKTFTATLANYAQVEG
HHCCCEEEEEEEECCCEEEEEECCCCCCHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCC
KLTLTDKVSQYLPELTGSAFDQINLINLATHTAGDLPMQVPDKVTNNAELMRYFKEWQPA
EEEEHHHHHHHHHHHCCCHHCCEEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCCH
YAAGTHRNYANPSIGLLGLIAAKQLGQSFPNAMEQTLFPQLGMTHSYLQVPSNKLADYAQ
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
GYNKQDQPVRLNPGVLAEEAYGIKTSAVDLLRFVETNMQQHPVPSVLQQAIDATHVGYFD
CCCCCCCCEECCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHH
VGMMTQEMIWEHYPYPIALDKLLAGHTQEVVFGSVPVKAIVPPQAPQPDLWINKTGSTGG
HHHHHHHHHHHHCCCCHHHHHHHCCCCHHEEECCCCEEEECCCCCCCCCEEEECCCCCCC
FAAYVAYIPAKKLGMVLLSNKNYPVPPRVTVGYQILTGLTALPAK
HHHHHHHHCHHHHCEEEECCCCCCCCCCEEEHHHHHHCCHHCCCC
>Mature Secondary Structure 
PESLQPAVKTARFLRLSNPSPFLGLVLLTAVPLVANAAPQVQTKAMQSLVDSAINPLMK
CCCCHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
EYGIPGAIVGISMNGQQYFFPYGVSSKTTEHHVSKNTLFEIGSISKTFTATLANYAQVEG
HHCCCEEEEEEEECCCEEEEEECCCCCCHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCC
KLTLTDKVSQYLPELTGSAFDQINLINLATHTAGDLPMQVPDKVTNNAELMRYFKEWQPA
EEEEHHHHHHHHHHHCCCHHCCEEEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHCCH
YAAGTHRNYANPSIGLLGLIAAKQLGQSFPNAMEQTLFPQLGMTHSYLQVPSNKLADYAQ
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHH
GYNKQDQPVRLNPGVLAEEAYGIKTSAVDLLRFVETNMQQHPVPSVLQQAIDATHVGYFD
CCCCCCCCEECCCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHH
VGMMTQEMIWEHYPYPIALDKLLAGHTQEVVFGSVPVKAIVPPQAPQPDLWINKTGSTGG
HHHHHHHHHHHHCCCCHHHHHHHCCCCHHEEECCCCEEEECCCCCCCCCEEEECCCCCCC
FAAYVAYIPAKKLGMVLLSNKNYPVPPRVTVGYQILTGLTALPAK
HHHHHHHHCHHHHCEEEECCCCCCCCCCEEEHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8703429 [H]