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The map label for this gene is cynR [H]

Identifier: 117920319

GI number: 117920319

Start: 2219231

End: 2220109

Strand: Direct

Name: cynR [H]

Synonym: Shewana3_1874

Alternate gene names: 117920319

Gene position: 2219231-2220109 (Clockwise)

Preceding gene: 117920311

Following gene: 117920326

Centisome position: 44.63

GC content: 49.72

Gene sequence:

>879_bases
ATGAATATTCGCCATCTGCATTACTTCCAACAACTCGCGCAATTACAGCATTTTGCCAAAGCGGCGAACGCCTGCCATGT
GACGCAACCGACGCTCTCTGCGGGGATCAGTGCCCTTGAAAAAAGCCTTGGCACTGAGCTGGTGGTGCGGGGCAGCCAGT
TTGTGGCGCTCACGGATGCGGGGCAGATCATGCTGCAATACGCTGAGAGAATGTTGCAGGAACAGGCGGCGTTAAAGCAG
GAATTGAGTCTGTTTCGCGGCCAGCTCACCGGTTCGTTACGGATTGGCATAGTGCCGCAATCGAGTATCGACATCATGCC
GCTGATTAAGCTGTTTAATCAGGCTTATCCCAATATCAGCATCAAGTTATCTGTGATGACCAATGGGCAATTGATTGAAA
GCCTGAGCTTACATAAAACCGATATCGGCCTTGGATTTGACGAACAACTCACCGAGGCTAATCGACGCAGCTTTGTGTTT
TATCCGCAGCGGGCCAATCAAATGGCGCTGTTGTCCTGTGATTCGGTTGATGACAGTGCAAGCAAGTGCTTGTCTTTATA
TGACATTGGCACGCGTCCCTTAGTGCTGCTGAGTCAAAATATGCAGTTTAGAAAATACATAGATAATGCAATGGCGCAGG
CGGGGATTGATTTTAATCTGGTGCTGGAAACCGACTCATTATTCCACCTAATCGGCGCGGTAAAACATGGCTTAGGCAGT
GCGATCGTCAGCCGCGGTATTGCCGAATCGGTGGCGCAACTCTTTGGGATCCCATATCAGCTTTTGGACGGTGTCAGTTC
AGGGCAAACGGTCTTTATGACCCGTAAGCACAGTATTACGCCCGCAATGAAAGCTTTTATGCGTCAGCTTGAGTCTTAA

Upstream 100 bases:

>100_bases
TCAAACTATTTTATGGATTGATAGAAGATTTCTATTAAACTATGGATACCAATAGGGTTTGATTTTTCAGATTTGTCTAA
AACACTATATCGAAAGCACT

Downstream 100 bases:

>100_bases
CCATCACTGGTTATTGCTTGCGCTTTGATGGATACCATACCAAAGCTGCCCGAGGGCAATACCGCCATCGTTGACGGGAA
TATGTTTGTTAGGCAGCACG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MNIRHLHYFQQLAQLQHFAKAANACHVTQPTLSAGISALEKSLGTELVVRGSQFVALTDAGQIMLQYAERMLQEQAALKQ
ELSLFRGQLTGSLRIGIVPQSSIDIMPLIKLFNQAYPNISIKLSVMTNGQLIESLSLHKTDIGLGFDEQLTEANRRSFVF
YPQRANQMALLSCDSVDDSASKCLSLYDIGTRPLVLLSQNMQFRKYIDNAMAQAGIDFNLVLETDSLFHLIGAVKHGLGS
AIVSRGIAESVAQLFGIPYQLLDGVSSGQTVFMTRKHSITPAMKAFMRQLES

Sequences:

>Translated_292_residues
MNIRHLHYFQQLAQLQHFAKAANACHVTQPTLSAGISALEKSLGTELVVRGSQFVALTDAGQIMLQYAERMLQEQAALKQ
ELSLFRGQLTGSLRIGIVPQSSIDIMPLIKLFNQAYPNISIKLSVMTNGQLIESLSLHKTDIGLGFDEQLTEANRRSFVF
YPQRANQMALLSCDSVDDSASKCLSLYDIGTRPLVLLSQNMQFRKYIDNAMAQAGIDFNLVLETDSLFHLIGAVKHGLGS
AIVSRGIAESVAQLFGIPYQLLDGVSSGQTVFMTRKHSITPAMKAFMRQLES
>Mature_292_residues
MNIRHLHYFQQLAQLQHFAKAANACHVTQPTLSAGISALEKSLGTELVVRGSQFVALTDAGQIMLQYAERMLQEQAALKQ
ELSLFRGQLTGSLRIGIVPQSSIDIMPLIKLFNQAYPNISIKLSVMTNGQLIESLSLHKTDIGLGFDEQLTEANRRSFVF
YPQRANQMALLSCDSVDDSASKCLSLYDIGTRPLVLLSQNMQFRKYIDNAMAQAGIDFNLVLETDSLFHLIGAVKHGLGS
AIVSRGIAESVAQLFGIPYQLLDGVSSGQTVFMTRKHSITPAMKAFMRQLES

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=286, Percent_Identity=31.1188811188811, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=31.2757201646091, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787879, Length=295, Percent_Identity=26.7796610169492, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788887, Length=147, Percent_Identity=35.3741496598639, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1788297, Length=261, Percent_Identity=26.8199233716475, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788296, Length=247, Percent_Identity=27.5303643724696, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081904, Length=146, Percent_Identity=30.1369863013699, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787601, Length=133, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=24.6478873239437, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790208, Length=146, Percent_Identity=30.1369863013699, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789204, Length=302, Percent_Identity=24.8344370860927, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI2367136, Length=122, Percent_Identity=32.7868852459016, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32195; Mature: 32195

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS00018 EF_HAND_1 ; PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRHLHYFQQLAQLQHFAKAANACHVTQPTLSAGISALEKSLGTELVVRGSQFVALTDA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEECH
GQIMLQYAERMLQEQAALKQELSLFRGQLTGSLRIGIVPQSSIDIMPLIKLFNQAYPNIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEE
IKLSVMTNGQLIESLSLHKTDIGLGFDEQLTEANRRSFVFYPQRANQMALLSCDSVDDSA
EEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHH
SKCLSLYDIGTRPLVLLSQNMQFRKYIDNAMAQAGIDFNLVLETDSLFHLIGAVKHGLGS
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHH
AIVSRGIAESVAQLFGIPYQLLDGVSSGQTVFMTRKHSITPAMKAFMRQLES
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNIRHLHYFQQLAQLQHFAKAANACHVTQPTLSAGISALEKSLGTELVVRGSQFVALTDA
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCEEEEECCEEEEEECH
GQIMLQYAERMLQEQAALKQELSLFRGQLTGSLRIGIVPQSSIDIMPLIKLFNQAYPNIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEE
IKLSVMTNGQLIESLSLHKTDIGLGFDEQLTEANRRSFVFYPQRANQMALLSCDSVDDSA
EEEEEEECCHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEECCCCCCEEEEEECCCCHHH
SKCLSLYDIGTRPLVLLSQNMQFRKYIDNAMAQAGIDFNLVLETDSLFHLIGAVKHGLGS
HHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHH
AIVSRGIAESVAQLFGIPYQLLDGVSSGQTVFMTRKHSITPAMKAFMRQLES
HHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]