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The map label for this gene is uraA [H]

Identifier: 117920088

GI number: 117920088

Start: 1932027

End: 1933265

Strand: Reverse

Name: uraA [H]

Synonym: Shewana3_1641

Alternate gene names: 117920088

Gene position: 1933265-1932027 (Counterclockwise)

Preceding gene: 117920093

Following gene: 117920086

Centisome position: 38.88

GC content: 52.14

Gene sequence:

>1239_bases
ATGAAACGACTCGCTATTCCGCTTCAGGGCGCGCAAATGCTGTTTGTTGCATTTGGCGCCCTAGTGCTAATGCCGCTACT
CACGGGGCTTGATACCAGTGTCGCCCTGTTTACTGCGGGTATTGGTACTCTACTGTTTCAGTTGATCACGAAACGCCAAG
TCCCTATCTTCCTCGCCTCCTCCTTCGCTTTTATTGCTCCAATTCTCTACGGAGTACAAACCTGGGGGATCCCATCAACC
ATGGGCGGCATCATTGCCGCGGGTCTAGTCTATGTGCTCCTTGGGGCACTCGTTAAAGTGCGCGGCACCGACTTTATCCA
TAAGCTGCTACCGCCTGTGGTGGTTGGCCCAGTGATTATTATCATTGGTCTAGGTTTAGCCCCTGTGGCGGTGAATATGG
CGCTGGGTAAAAGTGGAGATGGCAGTTTAACGCTCGTCCCCACCAATACGGCTTTGATTATTTCCCTCGCCTCACTCTGT
ACCACTATAGCTGTGGCTATTTTTGCCAAGGGCTTACTTAAAGTCATGCCGATTCTGGCGGGGATTGTGGTGGGTTATGG
CCTAAGTCTTGCCTTTGGTATCGTGGATTTTGCGGTGGTTACCGCAGCAAGCTGGATTGCTATCCCAAAATTTGTCGCGC
CCGAATTTAACTGGCATGCCATCGCCTTTATGATCCCAGTCGCGATTGCGCCTGCGGTTGAACATATTGGTGACATCCTT
GCCATTTCTAATGTCACGGGTAAAGACTTTATGAAAAAACCCGGCCTGCATCGCACCTTAACCGGTGACGGCGTCGCGAC
AATTGCCGCAGCAGCCTTCGGCGGTCCACCAAACACGACCTATTCGGAAGTGACAGGCGCTGTGACTTTAACCCGCAACT
TCGACCCCAAAATCATGACGTGGACAGCGATTACCGCCATTACATTGGCCTTCGTGGGTAAGTTAGGCGCCCTGATGCAA
ACCATTCCCGTCCCTGTGATGGGCGGCATCATGTGTTTGCTATTCGGTTCTATCGCCGCGGTGGGTTTAAACACCTTAAT
CCGCAATCATGTAGATTTATCCGAGCCACGTAACTTAAGCATTGTCGGCGTGACGCTGGTATTTGGTATCGGTGGTATGG
CCTTTGGCATCGGCTCCTTCAGCCTCACGGGCATCAGCCTCTGTGGTATTGTGGCCATCACCATGAATCTGTTGTTACCC
GCGAGCAAACACCACGAGCGTGACGCTGCATCACACTAA

Upstream 100 bases:

>100_bases
AAACAGTGATCCTTACCTACAATCGGGGCATTTTATAAGGAACATATAGCAACAAACTGTTATCATCTCGCGGTTTACCC
TAAATTTACGAGAATAATAA

Downstream 100 bases:

>100_bases
ACAGTGTGAGTTCGCGCAGTAAAGCATCACTTATCGCCTAATCCTTATGTTAGGAGCAGGCAACAAAAAAGCCGCTAAGT
TATTCACTTAACGGCTTTTT

Product: uracil-xanthine permease

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MKRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIIAAGLVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVPTNTALIISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ASKHHERDAASH

Sequences:

>Translated_412_residues
MKRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIIAAGLVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVPTNTALIISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ASKHHERDAASH
>Mature_412_residues
MKRLAIPLQGAQMLFVAFGALVLMPLLTGLDTSVALFTAGIGTLLFQLITKRQVPIFLASSFAFIAPILYGVQTWGIPST
MGGIIAAGLVYVLLGALVKVRGTDFIHKLLPPVVVGPVIIIIGLGLAPVAVNMALGKSGDGSLTLVPTNTALIISLASLC
TTIAVAIFAKGLLKVMPILAGIVVGYGLSLAFGIVDFAVVTAASWIAIPKFVAPEFNWHAIAFMIPVAIAPAVEHIGDIL
AISNVTGKDFMKKPGLHRTLTGDGVATIAAAAFGGPPNTTYSEVTGAVTLTRNFDPKIMTWTAITAITLAFVGKLGALMQ
TIPVPVMGGIMCLLFGSIAAVGLNTLIRNHVDLSEPRNLSIVGVTLVFGIGGMAFGIGSFSLTGISLCGIVAITMNLLLP
ASKHHERDAASH

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=393, Percent_Identity=25.4452926208651, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI40316845, Length=393, Percent_Identity=25.4452926208651, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI44680145, Length=426, Percent_Identity=24.8826291079812, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI44680143, Length=430, Percent_Identity=24.6511627906977, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1788843, Length=393, Percent_Identity=39.6946564885496, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI87081818, Length=421, Percent_Identity=37.7672209026128, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI87082181, Length=425, Percent_Identity=28.2352941176471, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790087, Length=370, Percent_Identity=24.3243243243243, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082178, Length=322, Percent_Identity=26.7080745341615, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=180, Percent_Identity=27.2222222222222, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=392, Percent_Identity=25.2551020408163, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 42596; Mature: 42596

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure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EEHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]