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The map label for this gene is 117919752

Identifier: 117919752

GI number: 117919752

Start: 1519014

End: 1520066

Strand: Reverse

Name: 117919752

Synonym: Shewana3_1304

Alternate gene names: NA

Gene position: 1520066-1519014 (Counterclockwise)

Preceding gene: 117919753

Following gene: 117919749

Centisome position: 30.57

GC content: 46.53

Gene sequence:

>1053_bases
ATGACTCATCCAATGATTTCAATTTCAGGTCGGAAAATAGGCATAGATTATCCTCCGTATATTGTTGCCGAACTGTCGGC
CAACCATAACGGTGATATTGAGCGCGCCAAACAGATTATTGCCATGGCGAAGCGCTGCAACGCCGATGCCATCAAGCTGC
AAACCTACAGCGCCGATACCATCACCTTAAACTCAAAAAAAGAAGAGTTTATGATCCGCGGTGGTTTATGGGATGGAAAA
AGTCTTTATGAACTCTATCAATGGGCACAAATGCCCTGGGAGTGGCATAAGCCTTTATTTGATTATGCACGCAACCTAGG
TATCACTATTTTCAGCTCACCGTTCGACAACACCGCCGTTGATCTGCTGGAGGATTTGAATGCACCCGTCTATAAGGTCG
CGTCATTTGAGGCCATTGATCTACCGCTGATAAAATACATTGCTGGCACCGGAAAACCTATGATTATCTCCACAGGCATG
GCCAACAGAGATGAAATAGCAGAAGCCGTAGAGGCGGCCCGCAGCGGAGGTTGTAACGAACTGGCTTTACTGCATTGTGT
CAGCAGCTATCCAGCACCTTCGTCCGAATACAATTTAAAAACCATTGCCGATTTAGCAAAACGCTTCAATGTCGTCGGCG
GATTATCCGACCATACCATAGACAATGTCACTGCAGTAACCTCCGTGGCAGTTGGTGCAGCCATAATAGAAAAACACGTA
ACATTGGATCGAAACTCTGGCGGGCCGGACGACAGTTTCTCCATTGAGGAGGTGGAATTAGAGCGTCTGTGCACAGATGC
CAAAATAGCCTGGCAGGCACTGGGGAAAGTGGACTATTCGCAGCAAAACAGCGAAAAAGCAACCATAAAATATCGACGTT
CCCTATACATAGTTAATGACAAAAAGGCTGGAGAGCTGATACTACAAGAAGATATTCGAAGTGTGAGGCCAGGATTTGGT
TTGGCACCCAAATTCTATGAGCAAATCATAGGCCGTAAACTGACAACCGATGTCAGCGTAAACTCGCCTGTCAGCTGGTC
AATGTTTGAGTGA

Upstream 100 bases:

>100_bases
AACACGCCAGAATGGCCAGCGCCTTATGAATTGTCCTAGCCTGATGCTCGGCATACAAGAACAGATTGACACTTATGTCT
TAATTTTTTAAAGGCTTTTT

Downstream 100 bases:

>100_bases
CCTGCTCAGCATGGGCTAGAGGGCTTTCGACAAGGTCTCAATAACATAGGCTTGCTGCTCCTCGGTTAGCCCGGGAAACA
ATGGCAAACTGAGGATGCGG

Product: N-acetylneuraminate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTHPMISISGRKIGIDYPPYIVAELSANHNGDIERAKQIIAMAKRCNADAIKLQTYSADTITLNSKKEEFMIRGGLWDGK
SLYELYQWAQMPWEWHKPLFDYARNLGITIFSSPFDNTAVDLLEDLNAPVYKVASFEAIDLPLIKYIAGTGKPMIISTGM
ANRDEIAEAVEAARSGGCNELALLHCVSSYPAPSSEYNLKTIADLAKRFNVVGGLSDHTIDNVTAVTSVAVGAAIIEKHV
TLDRNSGGPDDSFSIEEVELERLCTDAKIAWQALGKVDYSQQNSEKATIKYRRSLYIVNDKKAGELILQEDIRSVRPGFG
LAPKFYEQIIGRKLTTDVSVNSPVSWSMFE

Sequences:

>Translated_350_residues
MTHPMISISGRKIGIDYPPYIVAELSANHNGDIERAKQIIAMAKRCNADAIKLQTYSADTITLNSKKEEFMIRGGLWDGK
SLYELYQWAQMPWEWHKPLFDYARNLGITIFSSPFDNTAVDLLEDLNAPVYKVASFEAIDLPLIKYIAGTGKPMIISTGM
ANRDEIAEAVEAARSGGCNELALLHCVSSYPAPSSEYNLKTIADLAKRFNVVGGLSDHTIDNVTAVTSVAVGAAIIEKHV
TLDRNSGGPDDSFSIEEVELERLCTDAKIAWQALGKVDYSQQNSEKATIKYRRSLYIVNDKKAGELILQEDIRSVRPGFG
LAPKFYEQIIGRKLTTDVSVNSPVSWSMFE
>Mature_349_residues
THPMISISGRKIGIDYPPYIVAELSANHNGDIERAKQIIAMAKRCNADAIKLQTYSADTITLNSKKEEFMIRGGLWDGKS
LYELYQWAQMPWEWHKPLFDYARNLGITIFSSPFDNTAVDLLEDLNAPVYKVASFEAIDLPLIKYIAGTGKPMIISTGMA
NRDEIAEAVEAARSGGCNELALLHCVSSYPAPSSEYNLKTIADLAKRFNVVGGLSDHTIDNVTAVTSVAVGAAIIEKHVT
LDRNSGGPDDSFSIEEVELERLCTDAKIAWQALGKVDYSQQNSEKATIKYRRSLYIVNDKKAGELILQEDIRSVRPGFGL
APKFYEQIIGRKLTTDVSVNSPVSWSMFE

Specific function: Unknown

COG id: COG2089

COG function: function code M; Sialic acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis spsE [H]

Homologues:

Organism=Homo sapiens, GI12056473, Length=332, Percent_Identity=31.0240963855422, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21357081, Length=247, Percent_Identity=32.7935222672065, Blast_Score=138, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006190
- InterPro:   IPR013785
- InterPro:   IPR013132
- InterPro:   IPR013974 [H]

Pfam domain/function: PF03102 NeuB; PF08666 SAF [H]

EC number: NA

Molecular weight: Translated: 38764; Mature: 38633

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50844 AFP_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPMISISGRKIGIDYPPYIVAELSANHNGDIERAKQIIAMAKRCNADAIKLQTYSADT
CCCCEEEECCCEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCE
ITLNSKKEEFMIRGGLWDGKSLYELYQWAQMPWEWHKPLFDYARNLGITIFSSPFDNTAV
EEECCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHCCEEEEECCCCCHHH
DLLEDLNAPVYKVASFEAIDLPLIKYIAGTGKPMIISTGMANRDEIAEAVEAARSGGCNE
HHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCH
LALLHCVSSYPAPSSEYNLKTIADLAKRFNVVGGLSDHTIDNVTAVTSVAVGAAIIEKHV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLDRNSGGPDDSFSIEEVELERLCTDAKIAWQALGKVDYSQQNSEKATIKYRRSLYIVND
EEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHEEEEEEEEEEEEC
KKAGELILQEDIRSVRPGFGLAPKFYEQIIGRKLTTDVSVNSPVSWSMFE
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
THPMISISGRKIGIDYPPYIVAELSANHNGDIERAKQIIAMAKRCNADAIKLQTYSADT
CCCEEEECCCEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCE
ITLNSKKEEFMIRGGLWDGKSLYELYQWAQMPWEWHKPLFDYARNLGITIFSSPFDNTAV
EEECCCCCEEEEECCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHCCEEEEECCCCCHHH
DLLEDLNAPVYKVASFEAIDLPLIKYIAGTGKPMIISTGMANRDEIAEAVEAARSGGCNE
HHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCH
LALLHCVSSYPAPSSEYNLKTIADLAKRFNVVGGLSDHTIDNVTAVTSVAVGAAIIEKHV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TLDRNSGGPDDSFSIEEVELERLCTDAKIAWQALGKVDYSQQNSEKATIKYRRSLYIVND
EEECCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHEEEEEEEEEEEEC
KKAGELILQEDIRSVRPGFGLAPKFYEQIIGRKLTTDVSVNSPVSWSMFE
CCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]