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The map label for this gene is guaA [H]

Identifier: 117919685

GI number: 117919685

Start: 1441691

End: 1443268

Strand: Direct

Name: guaA [H]

Synonym: Shewana3_1236

Alternate gene names: 117919685

Gene position: 1441691-1443268 (Clockwise)

Preceding gene: 117919684

Following gene: 117919686

Centisome position: 29.0

GC content: 50.7

Gene sequence:

>1578_bases
ATGAGCGATATTCATGAGCATAAGATACTGATCCTCGACTTTGGATCTCAGTACACCCAGCTAATTGCCCGTCGTATCCG
TGAAATTGGTGTTTACTGTGAGTTATGGGCGTGGGATGTGACCGAAGCCCAAATCCGTGAGTTTGCCCCTAACGGGATTA
TCCTCGCTGGCGGCCCAGAAAGTGTTACTGCCGACAACTCTCCCCGTGCACCTGAATATGTGTTCAATGCTGGCGTACCC
GTTTTAGGGATCTGCTACGGCATGCAAACCATGTCTGAGCAGCTGGGCGGTAAAGTGATTCAAGGCGTGGGTGAAGGCGA
GTTCGGCTACGCTCAAATCGAAATGTTAGCGCAATCGGCTCTGTTTAAAGATATCGAAGACGCAGTCAGTGCCGATGGCA
AATCGCTGCTCGATGTGTGGATGAGCCATGGCGATAAAGTTTCGGCTATCCCAGAAGGTTTTGTGGCCGTTGCTAAAACT
GACACTTGCCCATTTGCGGCCATGTCTTGTGAGGAAAAACGTTTCTACGGCGTGCAGTTCCACCCTGAAGTAACCCATAC
CCGCCAGGGCATGCGTATGCTGTCGCACTTTGCCTTAGATATCTGCGGCTGTGCGGCCAACTGGAAACCTTCTTCAATCA
TCGAAGACGCTATCGAACGCTTGAAAAAGCAAGTTGGCGACGACGAAGTGATTTTAGGCCTGTCTGGTGGTGTGGATTCA
TCGGTAGTGGCCATGCTGCTGCACCGCGCAATTGGCAAAAAACTGACCTGCGTATTTGTTGATAACGGCTTACTGCGTTT
AAACGAAGCGAAGCAAGTCATGGAAATGTTTGGTGATCATTTCGGTCTGAACATTGTTCACGTCGATGCGGAAAACCGCT
TCCTTGACGCGCTGAAAGGCGAAGCCGATCCAGAAGCGAAACGTAAAATCATCGGCCGTGTATTCGTTGAGATCTTCGAC
GAAGAAGCCAAGAAATGCGTTAACGCTAAATGGTTAGCCCAAGGCACCATCTACCCAGACGTGATTGAATCTGCTGGCAG
CGCCACAGGTAAAGCCCATGTGATTAAGTCGCACCATAACGTTGGCGGTCTGCCAGACGATATGGAGTTAGGTCTGGTTG
AGCCTCTGCGCGAACTCTTTAAAGACGAAGTGCGTAAGATTGGCCTTGAGCTAGGTCTGCCATACAACATGCTTTACCGC
CACCCGTTCCCAGGCCCTGGTTTAGGCGTGCGTGTACTGGGCGAAGTGAAGAAAGAATACTGCGATTTGCTGCGCCGCGC
CGATGCGATTTTCATCGAAGAGCTGCATAAAGCTGATCTTTATAACAAAGTCAGCCAAGCCTTTACCGTGTTCTTACCCG
TTCGCTCTGTCGGTGTGATGGGCGATGGCCGTAAATACGATTGGGTGGTGTCACTGCGCGCCGTTGAAACCATCGACTTT
ATGACCGCTCACTGGGCGCACTTGCCATACGATTTCTTAGGCCGTGTGTCTAACCGTATCATCAACGAAATCGACGGCAT
ATCCCGTGTGGTTTACGATATTTCAGGTAAGCCACCTGCAACTATCGAGTGGGAATAG

Upstream 100 bases:

>100_bases
GCGGCGATAAGCCGCCCCGTTATTAAGATTTGTATGCCCTCAAGATTGAACCTCGCAGTCTTGAGCTAAGTTAAAACAAT
AGATGAGATAAAGGTTATCC

Downstream 100 bases:

>100_bases
CTCAAACATAAATAGCTAATAATATAATGATTTAACTCAATGCCAGTCACTTAATTGATTGGCATTTTTATTGGGATGAG
GGTATTTACCTAAAAATAAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTADNSPRAPEYVFNAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLAQSALFKDIEDAVSADGKSLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMSCEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQVGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAKQVMEMFGDHFGLNIVHVDAENRFLDALKGEADPEAKRKIIGRVFVEIFD
EEAKKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE

Sequences:

>Translated_525_residues
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTADNSPRAPEYVFNAGVP
VLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLAQSALFKDIEDAVSADGKSLLDVWMSHGDKVSAIPEGFVAVAKT
DTCPFAAMSCEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQVGDDEVILGLSGGVDS
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAKQVMEMFGDHFGLNIVHVDAENRFLDALKGEADPEAKRKIIGRVFVEIFD
EEAKKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
>Mature_524_residues
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPESVTADNSPRAPEYVFNAGVPV
LGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLAQSALFKDIEDAVSADGKSLLDVWMSHGDKVSAIPEGFVAVAKTD
TCPFAAMSCEEKRFYGVQFHPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQVGDDEVILGLSGGVDSS
VVAMLLHRAIGKKLTCVFVDNGLLRLNEAKQVMEMFGDHFGLNIVHVDAENRFLDALKGEADPEAKRKIIGRVFVEIFDE
EAKKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHNVGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRH
PFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDFM
TAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=574, Percent_Identity=34.6689895470383, Blast_Score=286, Evalue=4e-77,
Organism=Escherichia coli, GI1788854, Length=523, Percent_Identity=82.4091778202677, Blast_Score=911, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=579, Percent_Identity=33.8514680483592, Blast_Score=274, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI71992710, Length=579, Percent_Identity=33.6787564766839, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI133901714, Length=579, Percent_Identity=33.6787564766839, Blast_Score=273, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6323873, Length=524, Percent_Identity=49.4274809160305, Blast_Score=527, Evalue=1e-150,
Organism=Drosophila melanogaster, GI281365319, Length=564, Percent_Identity=35.2836879432624, Blast_Score=282, Evalue=5e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 58198; Mature: 58066

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTADNSPRAPEYVFNAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLAQSA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKDIEDAVSADGKSLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMSCEEKRFYGVQF
HHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCHHCCCCCCCEECEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQVGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAKQVMEMFGDHFGLNIVHVDAENRFLDALKG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCC
EADPEAKRKIIGRVFVEIFDEEAKKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC
>Mature Secondary Structure 
SDIHEHKILILDFGSQYTQLIARRIREIGVYCELWAWDVTEAQIREFAPNGIILAGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHCCCCCEEEECCCC
SVTADNSPRAPEYVFNAGVPVLGICYGMQTMSEQLGGKVIQGVGEGEFGYAQIEMLAQSA
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHHHHHHH
LFKDIEDAVSADGKSLLDVWMSHGDKVSAIPEGFVAVAKTDTCPFAAMSCEEKRFYGVQF
HHHHHHHHHCCCCHHHHHHHHHCCCCEECCCCCCEEEEECCCCCCHHCCCCCCCEECEEE
HPEVTHTRQGMRMLSHFALDICGCAANWKPSSIIEDAIERLKKQVGDDEVILGLSGGVDS
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCH
SVVAMLLHRAIGKKLTCVFVDNGLLRLNEAKQVMEMFGDHFGLNIVHVDAENRFLDALKG
HHHHHHHHHHHCCCEEEEEECCCCEEEHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHCC
EADPEAKRKIIGRVFVEIFDEEAKKCVNAKWLAQGTIYPDVIESAGSATGKAHVIKSHHN
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCHHHHHHCCCCCCCEEEEECCCC
VGGLPDDMELGLVEPLRELFKDEVRKIGLELGLPYNMLYRHPFPGPGLGVRVLGEVKKEY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHH
CDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCCCCCEEEEEEEHHHHHHHH
MTAHWAHLPYDFLGRVSNRIINEIDGISRVVYDISGKPPATIEWE
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA