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The map label for this gene is prs [H]

Identifier: 117919217

GI number: 117919217

Start: 887536

End: 888483

Strand: Reverse

Name: prs [H]

Synonym: Shewana3_0765

Alternate gene names: 117919217

Gene position: 888483-887536 (Counterclockwise)

Preceding gene: 117919218

Following gene: 117919215

Centisome position: 17.87

GC content: 49.05

Gene sequence:

>948_bases
GTGCCCGACATCAAGCTCTTTGCTGGGAACGCCACCCCCAGTCTCGCTAAGAAGATAGCCGATCGTCTATTTTGTAAACT
CGGAGACGCAGTGGTTGGTCGTTTCAGCGATGGTGAAATCAGTGTCCAAATTAACGAAAATGTACGTGGTGCCGATGTGT
TTATCATCCAATCCACCTGCGCCCCAACTAACGATAACCTAATGGAACTTATCGTTATGGTTGACGCGCTACGCCGTGCA
TCTGCCGGTCGTATCACTGCCGTTATTCCTTACTTTGGTTATGCTCGTCAAGACCGTCGCGTACGTAGCGCACGTGTACC
TATTACTGCGAAAGTCGTTGCTGACTTCCTGTCAAGCGTCGGTGTTGACCGCGTTCTGACCTGTGATTTACACGCAGAGC
AAATTCAAGGCTTCTTCGACGTACCAGTAGACAACGTGTTCGGTAGCCCAGTGCTGCTCGAAGATATGCTGGCGAAGAAA
TTAGATAACCCTGTGGTTGTTTCTCCAGATATCGGTGGTGTTGTCCGCGCTCGAGCAGTGGCAAAACTATTAGATGATTC
TGATCTGGCCATTATCGACAAGCGTCGTCCACAGGCAAACGTAGCACAAGTGATGCACATCATTGGTGACGTTCAAGGCC
GAGACTGCATTATCGTTGACGATATGATCGACACAGGCGGCACTCTGTGTAAAGCGGCTGAAGCCTTAAAAGAACACGGT
GCAAACCGCGTATTTGCTTACGCGACTCACCCAGTATTCTCTGGCAAAGCGGCTGAAAATATCGAAAACTCAGTGATCGA
TGAAGTTATCGTGACTGATACTGTACCTTTAAGCCCTGAAATGCTTAAAGTGGCTAAAGTGACTCAACTGACTATGTCGG
CCGTATTGGCAGAAGCCATTCGCCGCGTCAGCAACGAAGAGTCTATCTCTGCAATGTTCAGCCACTAA

Upstream 100 bases:

>100_bases
TAGAGCAACTTTTTACGATAGCCCACGGGTTCCGCTCCCGTCCCCGCATCGTCGTTGCTCTAGCCACTAAAATATAAAGC
AAACGCCTGAGGTTCATACA

Downstream 100 bases:

>100_bases
TCGCGGCGCTTTGCATAAAAAACGCACCTTAGGGTGCGTTTTTTGTTGGTGGATTTTATTGCGTTACTACTTTCGAGCTT
TTCGTATTAATAGCTCGTGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKK
LDNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIENSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFSH

Sequences:

>Translated_315_residues
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKK
LDNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
ANRVFAYATHPVFSGKAAENIENSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFSH
>Mature_314_residues
PDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTCAPTNDNLMELIVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKKL
DNPVVVSPDIGGVVRARAVAKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHGA
NRVFAYATHPVFSGKAAENIENSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAIRRVSNEESISAMFSH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=48.8958990536278, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=47.9495268138801, Blast_Score=302, Evalue=2e-82,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=47.6489028213166, Blast_Score=301, Evalue=4e-82,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=47.6340694006309, Blast_Score=296, Evalue=2e-80,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=37.6093294460641, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=37.3177842565598, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=32.4137931034483, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=83.4920634920635, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=46.0567823343849, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=46.0567823343849, Blast_Score=291, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=46.0567823343849, Blast_Score=290, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=45.5128205128205, Blast_Score=283, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=336, Percent_Identity=35.1190476190476, Blast_Score=197, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=46.8354430379747, Blast_Score=274, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=46.6666666666667, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6321776, Length=319, Percent_Identity=47.6489028213166, Blast_Score=267, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=40.5797101449275, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=44.3478260869565, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=46.6876971608833, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=43.6578171091445, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24651458, Length=355, Percent_Identity=34.6478873239437, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651456, Length=355, Percent_Identity=34.6478873239437, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI281362873, Length=355, Percent_Identity=34.6478873239437, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651454, Length=355, Percent_Identity=34.6478873239437, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24651462, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24651464, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI45552010, Length=184, Percent_Identity=38.0434782608696, Blast_Score=127, Evalue=9e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34014; Mature: 33882

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKKLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
AKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIENSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVSNEESISAMFSH
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
PDIKLFAGNATPSLAKKIADRLFCKLGDAVVGRFSDGEISVQINENVRGADVFIIQSTC
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELIVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTCDLHAEQIQGFFDVPVDNVFGSPVLLEDMLAKKLDNPVVVSPDIGGVVRARAV
CCCEEEEECCCHHHCCCEECCCHHHHCCCHHHHHHHHHHHCCCCEEECCCCCHHHHHHHH
AKLLDDSDLAIIDKRRPQANVAQVMHIIGDVQGRDCIIVDDMIDTGGTLCKAAEALKEHG
HHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHCC
ANRVFAYATHPVFSGKAAENIENSVIDEVIVTDTVPLSPEMLKVAKVTQLTMSAVLAEAI
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RRVSNEESISAMFSH
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]