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The map label for this gene is ccmA [H]

Identifier: 117918689

GI number: 117918689

Start: 260229

End: 260879

Strand: Reverse

Name: ccmA [H]

Synonym: Shewana3_0231

Alternate gene names: 117918689

Gene position: 260879-260229 (Counterclockwise)

Preceding gene: 117918691

Following gene: 117918688

Centisome position: 5.25

GC content: 43.47

Gene sequence:

>651_bases
GTGACAAATATAACTTCAGTAAACACACTGGTATCGGCGAGCAAGCTGACATGTATCCGCGAAGAACGCATCCTGTTTGA
TGAATTAAGTTTTGATATTAATGCTGGCGATATCGTCCAGATCGAAGGCCCAAATGGCGCCGGCAAAACCAGTTTATTAC
GTATATTGGCAGGCTTATCTCGTCCCTACGCTGGACAAACTTTTTATCTCAATGAAGATATTAACCGTTACCGCGACGAA
TATAACGAAGACCTATTGTATTTAGGCCATCTTGCTGGGGTGAAATCCGAATTATCCGCTGAAGAAAACCTTAACTTCAA
TTTAAGAATCAGTGGCTATGATGATTTCGATACTTCCGCCATTCTCGCTAAAGTGAATTTAGCCGGGTTTGAGGAAGCAC
TCGCCGGGCATTTATCCGCTGGTCAACACCGCCGTACAGCATTAGCCAGACTCTGGCACAATGACTGTAAAGTGTGGATC
CTCGATGAGCCTTTTACCGCAATCGATAAAAGAGGTGTCGAAGAGCTTGAACAGTTATTTATTCAACATGCGGATAATGG
TGGCTGCGTGATCCTCACCACTCACCAAGATATGGGCATTATCAAAGATGATAGGCTTCGTAAAATTCGTCTAGATTATC
GCTTCGTATAA

Upstream 100 bases:

>100_bases
ATCAAATTGCTGACATCTAGTATTAAGCAAGTGTAAACCCCGCAATATCGTTTGTGTTAGAATCACTTGTGTTTCCTTCC
GGCTTGAGATAGAGGGTTCA

Downstream 100 bases:

>100_bases
GGTTTGGCATAATGAAAAGAGGCATCAGCTTTACCCAAGCGTTTTTAACATTACTACAGCGGGATCTAAAAATCGCCATT
CGTCACCGCGGTGATATCTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTNITSVNTLVSASKLTCIREERILFDELSFDINAGDIVQIEGPNGAGKTSLLRILAGLSRPYAGQTFYLNEDINRYRDE
YNEDLLYLGHLAGVKSELSAEENLNFNLRISGYDDFDTSAILAKVNLAGFEEALAGHLSAGQHRRTALARLWHNDCKVWI
LDEPFTAIDKRGVEELEQLFIQHADNGGCVILTTHQDMGIIKDDRLRKIRLDYRFV

Sequences:

>Translated_216_residues
MTNITSVNTLVSASKLTCIREERILFDELSFDINAGDIVQIEGPNGAGKTSLLRILAGLSRPYAGQTFYLNEDINRYRDE
YNEDLLYLGHLAGVKSELSAEENLNFNLRISGYDDFDTSAILAKVNLAGFEEALAGHLSAGQHRRTALARLWHNDCKVWI
LDEPFTAIDKRGVEELEQLFIQHADNGGCVILTTHQDMGIIKDDRLRKIRLDYRFV
>Mature_215_residues
TNITSVNTLVSASKLTCIREERILFDELSFDINAGDIVQIEGPNGAGKTSLLRILAGLSRPYAGQTFYLNEDINRYRDEY
NEDLLYLGHLAGVKSELSAEENLNFNLRISGYDDFDTSAILAKVNLAGFEEALAGHLSAGQHRRTALARLWHNDCKVWIL
DEPFTAIDKRGVEELEQLFIQHADNGGCVILTTHQDMGIIKDDRLRKIRLDYRFV

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=182, Percent_Identity=31.8681318681319, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI21536376, Length=192, Percent_Identity=26.0416666666667, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI150417984, Length=182, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI153792144, Length=194, Percent_Identity=25.2577319587629, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI45446740, Length=218, Percent_Identity=25.6880733944954, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI47078218, Length=218, Percent_Identity=25.6880733944954, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI11967969, Length=198, Percent_Identity=26.7676767676768, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI27477115, Length=151, Percent_Identity=29.8013245033113, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI87082064, Length=205, Percent_Identity=50.2439024390244, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87081709, Length=149, Percent_Identity=33.5570469798658, Blast_Score=88, Evalue=3e-19,
Organism=Escherichia coli, GI1788761, Length=180, Percent_Identity=30.5555555555556, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081782, Length=170, Percent_Identity=33.5294117647059, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87081791, Length=189, Percent_Identity=29.6296296296296, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI2367384, Length=213, Percent_Identity=27.2300469483568, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787105, Length=202, Percent_Identity=28.2178217821782, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787370, Length=218, Percent_Identity=26.605504587156, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1789873, Length=194, Percent_Identity=27.8350515463918, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789593, Length=194, Percent_Identity=26.8041237113402, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786563, Length=181, Percent_Identity=27.0718232044199, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788165, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1786253, Length=151, Percent_Identity=29.1390728476821, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787164, Length=175, Percent_Identity=31.4285714285714, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790467, Length=153, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789991, Length=182, Percent_Identity=26.9230769230769, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787029, Length=180, Percent_Identity=28.8888888888889, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87082267, Length=151, Percent_Identity=25.8278145695364, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787712, Length=186, Percent_Identity=26.8817204301075, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48994943, Length=155, Percent_Identity=28.3870967741935, Blast_Score=63, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115533608, Length=193, Percent_Identity=27.979274611399, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24666092, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24648314, Length=189, Percent_Identity=26.984126984127, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28574744, Length=188, Percent_Identity=28.1914893617021, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 24362; Mature: 24231

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNITSVNTLVSASKLTCIREERILFDELSFDINAGDIVQIEGPNGAGKTSLLRILAGLS
CCCCCCHHHHHHHHHHHHHHHHHHEEHHHCEECCCCCEEEEECCCCCCHHHHHHHHHHCC
RPYAGQTFYLNEDINRYRDEYNEDLLYLGHLAGVKSELSAEENLNFNLRISGYDDFDTSA
CCCCCCEEEECCHHHHHHHHHCCCEEEEHHHHCCHHHCCCCCCCCEEEEECCCCCCCCCE
ILAKVNLAGFEEALAGHLSAGQHRRTALARLWHNDCKVWILDEPFTAIDKRGVEELEQLF
EEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHHHHHHHH
IQHADNGGCVILTTHQDMGIIKDDRLRKIRLDYRFV
HHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure 
TNITSVNTLVSASKLTCIREERILFDELSFDINAGDIVQIEGPNGAGKTSLLRILAGLS
CCCCCHHHHHHHHHHHHHHHHHHEEHHHCEECCCCCEEEEECCCCCCHHHHHHHHHHCC
RPYAGQTFYLNEDINRYRDEYNEDLLYLGHLAGVKSELSAEENLNFNLRISGYDDFDTSA
CCCCCCEEEECCHHHHHHHHHCCCEEEEHHHHCCHHHCCCCCCCCEEEEECCCCCCCCCE
ILAKVNLAGFEEALAGHLSAGQHRRTALARLWHNDCKVWILDEPFTAIDKRGVEELEQLF
EEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCHHHHHHHH
IQHADNGGCVILTTHQDMGIIKDDRLRKIRLDYRFV
HHCCCCCCEEEEEECCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]