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The map label for this gene is msrA [H]

Identifier: 117676268

GI number: 117676268

Start: 221669

End: 222331

Strand: Reverse

Name: msrA [H]

Synonym: Shewana3_4331

Alternate gene names: 117676268

Gene position: 222331-221669 (Counterclockwise)

Preceding gene: 117676269

Following gene: 117676265

Centisome position: 79.71

GC content: 43.89

Gene sequence:

>663_bases
ATGTCGGATCTAAAAATGAATAAAGAAGACGGTGTTGAAAGCTATGAATTTGCAACCCCTGAAGCAATCGAAGAAGCATT
GAAAATCGGGAAGCTTAGTCAAACGGTTTTCGGCATGGGTTGCTTTTGGGGACCGGATTCTAATTTTGGAGGGACGCAGG
GAGTAGTGCAAACACGTGTTGGCTACGCTGGAGCATCAACTCTGGATCCGAGTTACCGCAACATCAACGGACACGCCGAA
GTCGTCAGAGTGATCTACGATAAAGACCAAATCAGCTACAGGGAACTTCTTGGAAGTTTTGAATCATGGTCTGTTCATGG
TAGAAAGCAGGGCCAGTATCGCCAGATACTTTTTGTTTTTGATCTGGAGCAAAAACAAGTAGCTGAAGAACTGATTCAAG
CGATTGGAAAGGAGAAATCTCCCGAGGTGATTGAGGCCGGAGAACAAAATGGTTATTTTTGGCCCGCCGAAGATTACCAT
CAAAAGCATCGTCTTCGCAGAAACAAACAGCTTGTAAGTCTTGCAGAAGTAGATTTCGGTCCTCGCTGGGATGAACATCT
GTATTTTACTAAATTAAATAGTACCGATAGAAAAGGCTTCAGTCTCTCAAGCTGGCTAAAAAAGTTGTCTCCGGAAATGC
AGAAAGCTTACCGAATCGGTTAA

Upstream 100 bases:

>100_bases
GATACTTCATCAAGCTGGTGTTGGAAAACGTGGTCTTATCGTCGTTTGCACGGCGTGAGGAATGGGAGTGGCTTCAATTT
TTGAAAGTTAGGTGAAAAAT

Downstream 100 bases:

>100_bases
TCTGAAATTGCAGCTGGCTAAAGAACTCTATTTTCTATATGTAAAGAATGTGACGATCTCCTTCACATGGAGTCCAAGAG
AGCATAAAAAATCTGTGTAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSDLKMNKEDGVESYEFATPEAIEEALKIGKLSQTVFGMGCFWGPDSNFGGTQGVVQTRVGYAGASTLDPSYRNINGHAE
VVRVIYDKDQISYRELLGSFESWSVHGRKQGQYRQILFVFDLEQKQVAEELIQAIGKEKSPEVIEAGEQNGYFWPAEDYH
QKHRLRRNKQLVSLAEVDFGPRWDEHLYFTKLNSTDRKGFSLSSWLKKLSPEMQKAYRIG

Sequences:

>Translated_220_residues
MSDLKMNKEDGVESYEFATPEAIEEALKIGKLSQTVFGMGCFWGPDSNFGGTQGVVQTRVGYAGASTLDPSYRNINGHAE
VVRVIYDKDQISYRELLGSFESWSVHGRKQGQYRQILFVFDLEQKQVAEELIQAIGKEKSPEVIEAGEQNGYFWPAEDYH
QKHRLRRNKQLVSLAEVDFGPRWDEHLYFTKLNSTDRKGFSLSSWLKKLSPEMQKAYRIG
>Mature_219_residues
SDLKMNKEDGVESYEFATPEAIEEALKIGKLSQTVFGMGCFWGPDSNFGGTQGVVQTRVGYAGASTLDPSYRNINGHAEV
VRVIYDKDQISYRELLGSFESWSVHGRKQGQYRQILFVFDLEQKQVAEELIQAIGKEKSPEVIEAGEQNGYFWPAEDYHQ
KHRLRRNKQLVSLAEVDFGPRWDEHLYFTKLNSTDRKGFSLSSWLKKLSPEMQKAYRIG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=150, Percent_Identity=38, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI208609995, Length=150, Percent_Identity=38, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=34.8684210526316, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.986301369863, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=40.5882352941176, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45553131, Length=164, Percent_Identity=40.8536585365854, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=39.4117647058824, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 25185; Mature: 25053

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLKMNKEDGVESYEFATPEAIEEALKIGKLSQTVFGMGCFWGPDSNFGGTQGVVQTRV
CCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHC
GYAGASTLDPSYRNINGHAEVVRVIYDKDQISYRELLGSFESWSVHGRKQGQYRQILFVF
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEE
DLEQKQVAEELIQAIGKEKSPEVIEAGEQNGYFWPAEDYHQKHRLRRNKQLVSLAEVDFG
ECCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PRWDEHLYFTKLNSTDRKGFSLSSWLKKLSPEMQKAYRIG
CCCCCCEEEEECCCCCCCCCCHHHHHHHHCHHHHHHHCCC
>Mature Secondary Structure 
SDLKMNKEDGVESYEFATPEAIEEALKIGKLSQTVFGMGCFWGPDSNFGGTQGVVQTRV
CCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHC
GYAGASTLDPSYRNINGHAEVVRVIYDKDQISYRELLGSFESWSVHGRKQGQYRQILFVF
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEE
DLEQKQVAEELIQAIGKEKSPEVIEAGEQNGYFWPAEDYHQKHRLRRNKQLVSLAEVDFG
ECCHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
PRWDEHLYFTKLNSTDRKGFSLSSWLKKLSPEMQKAYRIG
CCCCCCEEEEECCCCCCCCCCHHHHHHHHCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA