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The map label for this gene is mnhD1 [H]

Identifier: 116873746

GI number: 116873746

Start: 2376299

End: 2377786

Strand: Direct

Name: mnhD1 [H]

Synonym: lwe2330

Alternate gene names: 116873746

Gene position: 2376299-2377786 (Clockwise)

Preceding gene: 116873745

Following gene: 116873747

Centisome position: 84.44

GC content: 38.1

Gene sequence:

>1488_bases
ATGATGAATAATTTAATTTTAATGCCGATATTGATACCTTTCTTTGGAGCAATTACTTTAATGTTACTTCCAAAAAGAGT
TATCGTCCAACGAATATTTGCCCTTATTTTCAGTGGTATTCTGGTTGTAGCATCACTATTTCTTGTTTTTTATATTCGAG
AAAATGGAATTACAACTGTTAACATTGGTAACTGGGCTGCTCCATTTGGAATTACGATGGTTGGCGATATGCTTGCGATT
TTACTTACTGCTACGACAAGCATTATTCTCTTCTGCGTGATTCTTTACTCCTTTTATACGATTGGGAAGCCACGTGAGAA
ATTTCTTTATTATCCAGCGATTCTCTTTATGATTGTTGGGGTAAATGGTTCGTTTTTAACTGGGGATATTTTCAATATGT
TTGTATTCTTTGAAGTTATGCTGATGGCTTCTTATGTGTTACTTGTCATTGGCGGGACACAAGTTCAACTTAAAGCAACG
ATAAAATATTTACTAATTAATGTGGTTGGTTCTGGATTTTTCGTTGTAGCGATTGCACTGCTTTATTCGATGATTGGCAC
ACTCAACATGGCGGATATTTCGCAAAAAATTACGGACTTAAATGGTGTGAACACTGGAATGATTAGTGTTGTCGCAGTAC
TCTTCTTGTTTGTATTCGGACTGAAAGCCGGGCTCTTCCCGCTTTATTTCTGGCTTCCTGGTTCTTACTTTGCACCGCCA
ATTCCAGTACTCGCCTTATTTGGCGGACTTTTGACAAAGGTTGGAGTTTACGCGATTATCCGAACTTACACACTATTCTT
TAGCTCACTCACTGACTTTGTTGTTCCGTTACTTGGAATTCTCGCGATTGTGACGATTATTCTTGGTGTTATTGGGGCAA
TTAGTTATTACGATATGAAAACGATTGTGATTTACAATATTATGATTGCGATTGGTATTATCTTGTTTAGTGTTTCGATT
ATGACTCGTGAATCGATGACCGGCGCTGTATTTTACTTAATTCACGATATGATCATCAAAGCCGCGCTCTTCCTTATTGT
TGGGATTGTTATGGCGATTACTGGTTACTCTAGTGTAAAAAAATTCAGCGGGCTTATGAGCGTCAAACCGTCACTTGGTT
GGGTTTTCTTTATTGCTACGCTTGGTCTTGCTGGAATCCCGCCTCTCAGCGGATTTATCGGAAAACTTTTGATTGTAGAA
GGAGCTTTCTCTGCTGGCCAAATTGTTGGCGGAATCATCGTTTTACTATCAAGTTTATTCGTTCTTATGTCTTTAATTAA
AGTCTTTACAAAAGGCTTCTGGGGTGAGAAAAAAGGGGTATTCAATTTACAAATCCCTTATAAAAAAATGCTTGTACCTG
TCGTGATTTTACTTGCGATTTCCATTGGTTATGGTGTGTTTAGTAACGCAATCTATCCGTTTATCGAACAGGCGGTTGAC
CCACTTGTTGACCCTTCTGTTTATATTCAAGCGGTGATAAAGGAGTGA

Upstream 100 bases:

>100_bases
ATAAGCTTTGGTGTAACTGCCTTTTTCCTTGTTCTTGCTTATAGAGCGTATCAGGAGCTTGATAGCGAGAGTGTATCCAA
GACGAGAGGACATGAAGCCG

Downstream 100 bases:

>100_bases
TAAAAGATGGCTTTTCAACTTATTCTTAATATAATACTTGCATGTTTGTGGATGTTTCTTGAGTCATCATTTAGTTTTGC
AACATTTATCATTGGCTTTA

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: Mnh complex subunit D1 [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MMNNLILMPILIPFFGAITLMLLPKRVIVQRIFALIFSGILVVASLFLVFYIRENGITTVNIGNWAAPFGITMVGDMLAI
LLTATTSIILFCVILYSFYTIGKPREKFLYYPAILFMIVGVNGSFLTGDIFNMFVFFEVMLMASYVLLVIGGTQVQLKAT
IKYLLINVVGSGFFVVAIALLYSMIGTLNMADISQKITDLNGVNTGMISVVAVLFLFVFGLKAGLFPLYFWLPGSYFAPP
IPVLALFGGLLTKVGVYAIIRTYTLFFSSLTDFVVPLLGILAIVTIILGVIGAISYYDMKTIVIYNIMIAIGIILFSVSI
MTRESMTGAVFYLIHDMIIKAALFLIVGIVMAITGYSSVKKFSGLMSVKPSLGWVFFIATLGLAGIPPLSGFIGKLLIVE
GAFSAGQIVGGIIVLLSSLFVLMSLIKVFTKGFWGEKKGVFNLQIPYKKMLVPVVILLAISIGYGVFSNAIYPFIEQAVD
PLVDPSVYIQAVIKE

Sequences:

>Translated_495_residues
MMNNLILMPILIPFFGAITLMLLPKRVIVQRIFALIFSGILVVASLFLVFYIRENGITTVNIGNWAAPFGITMVGDMLAI
LLTATTSIILFCVILYSFYTIGKPREKFLYYPAILFMIVGVNGSFLTGDIFNMFVFFEVMLMASYVLLVIGGTQVQLKAT
IKYLLINVVGSGFFVVAIALLYSMIGTLNMADISQKITDLNGVNTGMISVVAVLFLFVFGLKAGLFPLYFWLPGSYFAPP
IPVLALFGGLLTKVGVYAIIRTYTLFFSSLTDFVVPLLGILAIVTIILGVIGAISYYDMKTIVIYNIMIAIGIILFSVSI
MTRESMTGAVFYLIHDMIIKAALFLIVGIVMAITGYSSVKKFSGLMSVKPSLGWVFFIATLGLAGIPPLSGFIGKLLIVE
GAFSAGQIVGGIIVLLSSLFVLMSLIKVFTKGFWGEKKGVFNLQIPYKKMLVPVVILLAISIGYGVFSNAIYPFIEQAVD
PLVDPSVYIQAVIKE
>Mature_495_residues
MMNNLILMPILIPFFGAITLMLLPKRVIVQRIFALIFSGILVVASLFLVFYIRENGITTVNIGNWAAPFGITMVGDMLAI
LLTATTSIILFCVILYSFYTIGKPREKFLYYPAILFMIVGVNGSFLTGDIFNMFVFFEVMLMASYVLLVIGGTQVQLKAT
IKYLLINVVGSGFFVVAIALLYSMIGTLNMADISQKITDLNGVNTGMISVVAVLFLFVFGLKAGLFPLYFWLPGSYFAPP
IPVLALFGGLLTKVGVYAIIRTYTLFFSSLTDFVVPLLGILAIVTIILGVIGAISYYDMKTIVIYNIMIAIGIILFSVSI
MTRESMTGAVFYLIHDMIIKAALFLIVGIVMAITGYSSVKKFSGLMSVKPSLGWVFFIATLGLAGIPPLSGFIGKLLIVE
GAFSAGQIVGGIIVLLSSLFVLMSLIKVFTKGFWGEKKGVFNLQIPYKKMLVPVVILLAISIGYGVFSNAIYPFIEQAVD
PLVDPSVYIQAVIKE

Specific function: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=345, Percent_Identity=22.6086956521739, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1788829, Length=426, Percent_Identity=25.8215962441315, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1788827, Length=370, Percent_Identity=26.2162162162162, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788613, Length=431, Percent_Identity=25.754060324826, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788614, Length=479, Percent_Identity=25.2609603340292, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788831, Length=287, Percent_Identity=23.6933797909408, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI2367154, Length=422, Percent_Identity=22.9857819905213, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693160, Length=249, Percent_Identity=26.1044176706827, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004775
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 54005; Mature: 54005

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNNLILMPILIPFFGAITLMLLPKRVIVQRIFALIFSGILVVASLFLVFYIRENGITTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
NIGNWAAPFGITMVGDMLAILLTATTSIILFCVILYSFYTIGKPREKFLYYPAILFMIVG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VNGSFLTGDIFNMFVFFEVMLMASYVLLVIGGTQVQLKATIKYLLINVVGSGFFVVAIAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHH
LYSMIGTLNMADISQKITDLNGVNTGMISVVAVLFLFVFGLKAGLFPLYFWLPGSYFAPP
HHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IPVLALFGGLLTKVGVYAIIRTYTLFFSSLTDFVVPLLGILAIVTIILGVIGAISYYDMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIVIYNIMIAIGIILFSVSIMTRESMTGAVFYLIHDMIIKAALFLIVGIVMAITGYSSVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
KFSGLMSVKPSLGWVFFIATLGLAGIPPLSGFIGKLLIVEGAFSAGQIVGGIIVLLSSLF
HHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VLMSLIKVFTKGFWGEKKGVFNLQIPYKKMLVPVVILLAISIGYGVFSNAIYPFIEQAVD
HHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLVDPSVYIQAVIKE
HCCCHHHHHHHHHCC
>Mature Secondary Structure
MMNNLILMPILIPFFGAITLMLLPKRVIVQRIFALIFSGILVVASLFLVFYIRENGITTV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
NIGNWAAPFGITMVGDMLAILLTATTSIILFCVILYSFYTIGKPREKFLYYPAILFMIVG
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
VNGSFLTGDIFNMFVFFEVMLMASYVLLVIGGTQVQLKATIKYLLINVVGSGFFVVAIAL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHH
LYSMIGTLNMADISQKITDLNGVNTGMISVVAVLFLFVFGLKAGLFPLYFWLPGSYFAPP
HHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IPVLALFGGLLTKVGVYAIIRTYTLFFSSLTDFVVPLLGILAIVTIILGVIGAISYYDMK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIVIYNIMIAIGIILFSVSIMTRESMTGAVFYLIHDMIIKAALFLIVGIVMAITGYSSVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
KFSGLMSVKPSLGWVFFIATLGLAGIPPLSGFIGKLLIVEGAFSAGQIVGGIIVLLSSLF
HHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VLMSLIKVFTKGFWGEKKGVFNLQIPYKKMLVPVVILLAISIGYGVFSNAIYPFIEQAVD
HHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLVDPSVYIQAVIKE
HCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA