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The map label for this gene is pepC [H]

Identifier: 116873706

GI number: 116873706

Start: 2330876

End: 2332201

Strand: Direct

Name: pepC [H]

Synonym: lwe2290

Alternate gene names: 116873706

Gene position: 2330876-2332201 (Clockwise)

Preceding gene: 116873701

Following gene: 116873728

Centisome position: 82.83

GC content: 34.39

Gene sequence:

>1326_bases
ATGAGTGCAGAACTAACTTTAGACCAAGTAGAAATTTTTTCGAAAAAATGGCGTGAAAATCCAGATAAATTGGTGTTTCA
AGCTAGTATTATGAAAAATGGAATTAAAGCAGCAACTGAAAATCCTATTTCAAAAGTGAACAATCAACCCATCTTTTCTC
ACGAAGTTAAAACAGAGAAAGTTTCTAACCAACAGCAAAGTGGTAGATGTTGGATGTTTGCAGCATTAAATACATTCCGT
CATAAATTAAACGGAACACTTGGTTTAAAAGATTTTGAGTTATCTCAGAACTATACTAATTTTTGGGATAAATTAGAGAA
AGCTAATTATTTTTTAGAGAATATTATTGAAACTGCGAATGAAGATGAAGATAGTCGATTAGTTTCGTGGTTACTTGATA
CACCACAACAAGATGGTGGTCAGTGGGATATGTTAGTTTCTATTATTGAAAAATACGGGGTTGTTCCAAAGTCAGCTATG
CCGGAAACTTATCAAAGTAGCAAGTCTGCGGATTTGAATCACCTTTTAAATGAAAGGCTTCGCACAGATGCGGTTATTTT
AAGAAAAGCTGTTCAAGAAAAGAAAGATACTGCCATGTTGAAAGAAGAAATGCTTGCCGAGGTTTATCAGCTCTTAGTTC
TGACACTTGGTGAGCCGCCAAAAGTATTTGATTTTGAATATCGGAATAAAGATAATGAATTTAAACAAGATTTACAAATT
ACACCTAAAGATTTTTATGAACGTTATATTGACATGGATTTAAAAAATTATATTCCACTTATTAACGCACCGACTAAGGA
TAAACCCTTCAATCAAGCTTTTACAGTGGATTATTTAGGTAATATTGTAGATGGTACACCTATTAAATATTTGAATGTAG
AAATGAATGTATTAAAAAAAGCCGCCGCAGATCAAATTAAAGAAGGTGAAACAGTTTGGTTTGGCTGTGACGTAGGGCAA
CTTTCAGAACGAACTAGCGGCATCATGGACACTGATATTTTCTTGTTAAATCAAGCATTTGGATTTAAATCTGCAATGAC
AAAAGCTGAGCGTCTTGATTATAAACATAGTATGCTTACCCACGCGATGGTTCTGACAGGAGTGAATGTGGCTAATGGTT
CTGTAAATCGTTGGAAAGTCGAAAACAGTTGGGGAGAAAAAATCGGTAATAATGGCTATTTTGTTGCTAGCGACACTTGG
ATGGATGAGTACACATTCCAGGTAGTTGTGCATAAAAAACATTTATCTAAAGACTTGATTGAAGCTTTTAATCAAAAACC
AATCGCTTTAAAACCATGGGATCCTATGGGGTCATTAGCTCTTTAA

Upstream 100 bases:

>100_bases
TAATCTGTCATAAGCTTTCAAATAATTGTTTTCTTATACACTTTTTATTTTTAGCAGTATAATTAATTATAAGAAGGCAA
TTTATATAGGAGGAATGAAC

Downstream 100 bases:

>100_bases
ATTGTAAATTCTGAAATGATTTTTATCCCATTCATTTGAAAAAGAGCTGCTGCTACGCCGGTACCATCTTTTATTTTCCC
AGAGAAGGTACCGTCGTAAA

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MSAELTLDQVEIFSKKWRENPDKLVFQASIMKNGIKAATENPISKVNNQPIFSHEVKTEKVSNQQQSGRCWMFAALNTFR
HKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETANEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAM
PETYQSSKSADLNHLLNERLRTDAVILRKAVQEKKDTAMLKEEMLAEVYQLLVLTLGEPPKVFDFEYRNKDNEFKQDLQI
TPKDFYERYIDMDLKNYIPLINAPTKDKPFNQAFTVDYLGNIVDGTPIKYLNVEMNVLKKAAADQIKEGETVWFGCDVGQ
LSERTSGIMDTDIFLLNQAFGFKSAMTKAERLDYKHSMLTHAMVLTGVNVANGSVNRWKVENSWGEKIGNNGYFVASDTW
MDEYTFQVVVHKKHLSKDLIEAFNQKPIALKPWDPMGSLAL

Sequences:

>Translated_441_residues
MSAELTLDQVEIFSKKWRENPDKLVFQASIMKNGIKAATENPISKVNNQPIFSHEVKTEKVSNQQQSGRCWMFAALNTFR
HKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETANEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAM
PETYQSSKSADLNHLLNERLRTDAVILRKAVQEKKDTAMLKEEMLAEVYQLLVLTLGEPPKVFDFEYRNKDNEFKQDLQI
TPKDFYERYIDMDLKNYIPLINAPTKDKPFNQAFTVDYLGNIVDGTPIKYLNVEMNVLKKAAADQIKEGETVWFGCDVGQ
LSERTSGIMDTDIFLLNQAFGFKSAMTKAERLDYKHSMLTHAMVLTGVNVANGSVNRWKVENSWGEKIGNNGYFVASDTW
MDEYTFQVVVHKKHLSKDLIEAFNQKPIALKPWDPMGSLAL
>Mature_440_residues
SAELTLDQVEIFSKKWRENPDKLVFQASIMKNGIKAATENPISKVNNQPIFSHEVKTEKVSNQQQSGRCWMFAALNTFRH
KLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETANEDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAMP
ETYQSSKSADLNHLLNERLRTDAVILRKAVQEKKDTAMLKEEMLAEVYQLLVLTLGEPPKVFDFEYRNKDNEFKQDLQIT
PKDFYERYIDMDLKNYIPLINAPTKDKPFNQAFTVDYLGNIVDGTPIKYLNVEMNVLKKAAADQIKEGETVWFGCDVGQL
SERTSGIMDTDIFLLNQAFGFKSAMTKAERLDYKHSMLTHAMVLTGVNVANGSVNRWKVENSWGEKIGNNGYFVASDTWM
DEYTFQVVVHKKHLSKDLIEAFNQKPIALKPWDPMGSLAL

Specific function: Unknown

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family [H]

Homologues:

Organism=Homo sapiens, GI4557367, Length=405, Percent_Identity=40.4938271604938, Blast_Score=341, Evalue=9e-94,
Organism=Saccharomyces cerevisiae, GI6324090, Length=406, Percent_Identity=37.9310344827586, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI161077632, Length=402, Percent_Identity=40.0497512437811, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI24640588, Length=402, Percent_Identity=40.0497512437811, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI161077630, Length=362, Percent_Identity=39.5027624309392, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI20130175, Length=409, Percent_Identity=27.3838630806846, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000169
- InterPro:   IPR004134 [H]

Pfam domain/function: PF03051 Peptidase_C1_2 [H]

EC number: =3.4.22.40 [H]

Molecular weight: Translated: 50579; Mature: 50448

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00139 THIOL_PROTEASE_CYS ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELTLDQVEIFSKKWRENPDKLVFQASIMKNGIKAATENPISKVNNQPIFSHEVKTEK
CCCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHCCCHHHCCCHHHHCCCCCCCCHHHHHHH
VSNQQQSGRCWMFAALNTFRHKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETAN
HCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
EDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAMPETYQSSKSADLNHLLNERL
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHH
RTDAVILRKAVQEKKDTAMLKEEMLAEVYQLLVLTLGEPPKVFDFEYRNKDNEFKQDLQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHCCC
TPKDFYERYIDMDLKNYIPLINAPTKDKPFNQAFTVDYLGNIVDGTPIKYLNVEMNVLKK
CHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCEEEEEHHHHHHHH
AAADQIKEGETVWFGCDVGQLSERTSGIMDTDIFLLNQAFGFKSAMTKAERLDYKHSMLT
HHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HAMVLTGVNVANGSVNRWKVENSWGEKIGNNGYFVASDTWMDEYTFQVVVHKKHLSKDLI
HHHHHHCCEECCCCCCEEEECCCHHHHCCCCCEEEEECCCCCCEEEEEEEEHHHHHHHHH
EAFNQKPIALKPWDPMGSLAL
HHHCCCCCEECCCCCCCCCCC
>Mature Secondary Structure 
SAELTLDQVEIFSKKWRENPDKLVFQASIMKNGIKAATENPISKVNNQPIFSHEVKTEK
CCCCCHHHHHHHHHHHHCCCHHEEEHHHHHHCCCHHHCCCHHHHCCCCCCCCHHHHHHH
VSNQQQSGRCWMFAALNTFRHKLNGTLGLKDFELSQNYTNFWDKLEKANYFLENIIETAN
HCCCCCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
EDEDSRLVSWLLDTPQQDGGQWDMLVSIIEKYGVVPKSAMPETYQSSKSADLNHLLNERL
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHH
RTDAVILRKAVQEKKDTAMLKEEMLAEVYQLLVLTLGEPPKVFDFEYRNKDNEFKQDLQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHCCCCHHHHHHCCC
TPKDFYERYIDMDLKNYIPLINAPTKDKPFNQAFTVDYLGNIVDGTPIKYLNVEMNVLKK
CHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHCCCCCCCCEEEEEHHHHHHHH
AAADQIKEGETVWFGCDVGQLSERTSGIMDTDIFLLNQAFGFKSAMTKAERLDYKHSMLT
HHHHHHCCCCEEEEECCHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
HAMVLTGVNVANGSVNRWKVENSWGEKIGNNGYFVASDTWMDEYTFQVVVHKKHLSKDLI
HHHHHHCCEECCCCCCEEEECCCHHHHCCCCCEEEEECCCCCCEEEEEEEEHHHHHHHHH
EAFNQKPIALKPWDPMGSLAL
HHHCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]