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The map label for this gene is zwf [H]

Identifier: 116873413

GI number: 116873413

Start: 2024783

End: 2026258

Strand: Direct

Name: zwf [H]

Synonym: lwe1997

Alternate gene names: 116873413

Gene position: 2024783-2026258 (Clockwise)

Preceding gene: 116873409

Following gene: 116873414

Centisome position: 71.95

GC content: 38.62

Gene sequence:

>1476_bases
ATGACAGATGAGTTAGAACAAAAAGCATTGATTACTATTTTTGGCGGTACGGGAGATTTGGCAAATCGCAAACTTTACCC
TTCGTTATATCATTTATATAGTAAGGGATCTCTTGGCGACAATTTTGCTGTTATTGGAACGGCTCGTCGTGAATGGAGTA
ACGATTTCTTCCGTGATAAAGTAAAAGAGTCTATTAAAGACATTGATGGTTCCGAAAAAGACGCGGATGCCTTTGCTTCT
CATTTCTACTATCAATCCCATGATGTAACAAATAAAGAATCTTATGTAACTTTAAAAGATTTGTCTGATGAGCTAGATGC
TAAATATGAACTAGATGGTAATCGTCTTTTCTATCTTGCAATGGCGCCAAATTTCTTTGGGACTATCGCAAGCCGTATTA
AATCGGAAGGTTTTGTAGATACAAAAGGTTTCCATCGTTTAATTATCGAAAAACCTTTTGGACATGATTTAGCTAGCGCG
GAAGAATTAAATAATTCCCTTCGCCAAGCATTTAATGAAGATGAAATTTATCGTATTGATCATTATTTAGGCAAAGAAAT
GATTCAAAATATCTCGGTCATTCGATTTGCTAATTCGATTATTGAATCGCTTTGGAACAATCGGTATATTGATAATATCC
AAGTTACTTTGACAGAAGTGCTTGGCGTAGAGGACCGCGGACGCTATTATGACGAAAGCGGTGCACTTCGAGACATGGTT
CAAAACCATATCTTACAAATCGTTTCCCTACTCGCGATGGAACCACCAATTAACTTATCGACACGCGAAATTCGACATGA
AAAAGTGCGCGCGCTTCGTTCTTTACGTGTTTTTGAAGGAAAAGAAGTACATCAAAACTTTATCCGTGGACAATATGGTC
CTGGTGAAGTGGATGGTAAAGAACTAAAAGGCTACCGTCAAGAAGACAATGTCGATCCACATTCGAATACAGAAACATTT
GTGGCAGCCAAACTTGAAATCGACAATTTCCGCTGGGCTGGCGTTCCATTTTACATTCGTACTGGTAAACGTCTTGCGAA
GAAAACTACACAAATCGCGATTCAATTCAAAGATGTGCCGCTAAACCTATTTGGTCATCAACAATCACTTGGTGGAAATG
TCCTTGTTATTCATATCCAACCTGATGAAGGTATTACTCTTCATCTAAATGTGAAAGAGCCTGGACAAGGAATGGTTACG
ATGCCAGTTAATTTAAACTATGTTCATTCTTCTCCAGATGGTATGAATACACCTGAAGCATATGAAAAATTAATTCTAGA
CTGTTTGCGCGGCGATGCGACTTACTTCTCTCATTGGGATGAAGTATCACTTTCCTGGAACTTTATTGATCATGTGGCGG
ATGTTTGGACGAATACAAAAGATTATTTCCCTAATTATAAATCCGGCTCCATGGGTCCAAAAGAAGCAGACGAACTTATT
CAACGCGACGGATTCCAGTGGTTCCCAATCGATTAA

Upstream 100 bases:

>100_bases
ATAAGGCCTTTTTTTGTGGGGTTCTTTTCAAACTAAGAAATCTTTTTCTTAGCAGTTAATTTTTTGCCATTAAGAGAATA
AGAAAGAGGGTAAATGACGT

Downstream 100 bases:

>100_bases
TCAAAAAACCAGAAATATGGCTAAGTTAGCCTGTTTCTGGTTTTCTTTGTTTACTTGCAAAAGTTCCCTAGCATGTTAGA
ATAGAGAGGAAAACTAACTA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDKVKESIKDIDGSEKDADAFAS
HFYYQSHDVTNKESYVTLKDLSDELDAKYELDGNRLFYLAMAPNFFGTIASRIKSEGFVDTKGFHRLIIEKPFGHDLASA
EELNNSLRQAFNEDEIYRIDHYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMV
QNHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQNFIRGQYGPGEVDGKELKGYRQEDNVDPHSNTETF
VAAKLEIDNFRWAGVPFYIRTGKRLAKKTTQIAIQFKDVPLNLFGHQQSLGGNVLVIHIQPDEGITLHLNVKEPGQGMVT
MPVNLNYVHSSPDGMNTPEAYEKLILDCLRGDATYFSHWDEVSLSWNFIDHVADVWTNTKDYFPNYKSGSMGPKEADELI
QRDGFQWFPID

Sequences:

>Translated_491_residues
MTDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDKVKESIKDIDGSEKDADAFAS
HFYYQSHDVTNKESYVTLKDLSDELDAKYELDGNRLFYLAMAPNFFGTIASRIKSEGFVDTKGFHRLIIEKPFGHDLASA
EELNNSLRQAFNEDEIYRIDHYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMV
QNHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQNFIRGQYGPGEVDGKELKGYRQEDNVDPHSNTETF
VAAKLEIDNFRWAGVPFYIRTGKRLAKKTTQIAIQFKDVPLNLFGHQQSLGGNVLVIHIQPDEGITLHLNVKEPGQGMVT
MPVNLNYVHSSPDGMNTPEAYEKLILDCLRGDATYFSHWDEVSLSWNFIDHVADVWTNTKDYFPNYKSGSMGPKEADELI
QRDGFQWFPID
>Mature_490_residues
TDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDKVKESIKDIDGSEKDADAFASH
FYYQSHDVTNKESYVTLKDLSDELDAKYELDGNRLFYLAMAPNFFGTIASRIKSEGFVDTKGFHRLIIEKPFGHDLASAE
ELNNSLRQAFNEDEIYRIDHYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMVQ
NHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQNFIRGQYGPGEVDGKELKGYRQEDNVDPHSNTETFV
AAKLEIDNFRWAGVPFYIRTGKRLAKKTTQIAIQFKDVPLNLFGHQQSLGGNVLVIHIQPDEGITLHLNVKEPGQGMVTM
PVNLNYVHSSPDGMNTPEAYEKLILDCLRGDATYFSHWDEVSLSWNFIDHVADVWTNTKDYFPNYKSGSMGPKEADELIQ
RDGFQWFPID

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=488, Percent_Identity=36.6803278688525, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI108773793, Length=488, Percent_Identity=36.6803278688525, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI52145310, Length=369, Percent_Identity=32.2493224932249, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788158, Length=489, Percent_Identity=38.4458077709611, Blast_Score=359, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17538218, Length=486, Percent_Identity=35.59670781893, Blast_Score=313, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6324088, Length=488, Percent_Identity=37.0901639344262, Blast_Score=310, Evalue=5e-85,
Organism=Drosophila melanogaster, GI24643350, Length=480, Percent_Identity=35.625, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=480, Percent_Identity=35.625, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI221513548, Length=492, Percent_Identity=27.2357723577236, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56233; Mature: 56102

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDK
CCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEECCHHHHCHHHHHHH
VKESIKDIDGSEKDADAFASHFYYQSHDVTNKESYVTLKDLSDELDAKYELDGNRLFYLA
HHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCEEEHHHCCHHCCCEEEECCCEEEEEE
MAPNFFGTIASRIKSEGFVDTKGFHRLIIEKPFGHDLASAEELNNSLRQAFNEDEIYRID
ECCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEHH
HYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHCCCCCCCEECCCCHHHHHH
QNHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQNFIRGQYGPGEVDGK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHH
ELKGYRQEDNVDPHSNTETFVAAKLEIDNFRWAGVPFYIRTGKRLAKKTTQIAIQFKDVP
HHCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCHHHHHHCEEEEEEEECCC
LNLFGHQQSLGGNVLVIHIQPDEGITLHLNVKEPGQGMVTMPVNLNYVHSSPDGMNTPEA
EEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCHHH
YEKLILDCLRGDATYFSHWDEVSLSWNFIDHVADVWTNTKDYFPNYKSGSMGPKEADELI
HHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHH
QRDGFQWFPID
HHCCCEEECCC
>Mature Secondary Structure 
TDELEQKALITIFGGTGDLANRKLYPSLYHLYSKGSLGDNFAVIGTARREWSNDFFRDK
CCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEECCHHHHCHHHHHHH
VKESIKDIDGSEKDADAFASHFYYQSHDVTNKESYVTLKDLSDELDAKYELDGNRLFYLA
HHHHHHHCCCCCCHHHHHHHHHEEECCCCCCCCCEEEHHHCCHHCCCEEEECCCEEEEEE
MAPNFFGTIASRIKSEGFVDTKGFHRLIIEKPFGHDLASAEELNNSLRQAFNEDEIYRID
ECCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEHH
HYLGKEMIQNISVIRFANSIIESLWNNRYIDNIQVTLTEVLGVEDRGRYYDESGALRDMV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEHHHHCCCCCCCEECCCCHHHHHH
QNHILQIVSLLAMEPPINLSTREIRHEKVRALRSLRVFEGKEVHQNFIRGQYGPGEVDGK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHH
ELKGYRQEDNVDPHSNTETFVAAKLEIDNFRWAGVPFYIRTGKRLAKKTTQIAIQFKDVP
HHCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCHHHHHHCEEEEEEEECCC
LNLFGHQQSLGGNVLVIHIQPDEGITLHLNVKEPGQGMVTMPVNLNYVHSSPDGMNTPEA
EEEECCCCCCCCCEEEEEEECCCCEEEEEEECCCCCCEEEEEEEEEEEECCCCCCCCHHH
YEKLILDCLRGDATYFSHWDEVSLSWNFIDHVADVWTNTKDYFPNYKSGSMGPKEADELI
HHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHHHHCCCHHHCCCCCCCCCCHHHHHHHH
QRDGFQWFPID
HHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]