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The map label for this gene is ppdK [H]

Identifier: 116873302

GI number: 116873302

Start: 1913970

End: 1916609

Strand: Direct

Name: ppdK [H]

Synonym: lwe1886

Alternate gene names: 116873302

Gene position: 1913970-1916609 (Clockwise)

Preceding gene: 116873301

Following gene: 116873314

Centisome position: 68.01

GC content: 39.81

Gene sequence:

>2640_bases
GTGAGAAAATTTGTTTATCAGTTCAGTGAAGGATCTAAAGACATGAAAAATCTATTAGGAGGAAAAGGCGCTAATTTGGC
CGAAATGACGAATATTGGTTTACCTGTTCCTCCTGGTTTTATTATCTCGACCGATGCTTGTAATGATTACACAACTGGCA
ATAAACATCTATCCGAAGAGATTTTTGAAGAAGTGAAAATTCATTTGTCTAAACTCGAAACACAAACTGGAAAAGTTTTC
GGAAGTACAGAAAATCCTCTCCTAGTTTCGGTACGTTCTGGTGCTCCTTTTTCGATGCCTGGCATGATGGATACCGTTTT
AAATCTTGGTTTGAATGATTCTGCGGCTAGAGGCTTAGCTGATTTAACCGGTGACGCTCGTTCTGCATATGACTCCTATC
GTCGTTTTATTCAAATGTTTGGTGATGTCGTTTTTGAAATTCCTAGCTATCAATTTGAACAGGCGCTGAGTCGTATTAAA
AAAGCGAACAATTACCTTTTAGATACAGAATTAACTGCAGATGATTTGACTGAACTTATAGATGCTTATAAACTGATTTT
CAGCCAAGCAACCGGCAATGATTTTCCGCAAAACCCTCTGGAACAACTAAGACTCGCAATTATCGCTGTCTTTGATTCGT
GGATGAATCCTCGTGCTGTAATTTATCGTAGACTACATGATATAGATGCGAGCTTGGGTACTGCCGTGAATATTCAAGCC
ATGGTTTTTGGAAATACTGGCGAATCAAGTGGAACTGGAATTACTTTTACCCGAAATCCGTCGACTGGGGAAAAAGAAGT
ATTTGGCGAGTTTTTACTTAATGCACAAGGAGAAGATGTTGTAGCAGGTATTCGTACACCTGAACCGATAAGTGCGCTAC
AGATGAGAATGCCAATGGTTTACAACGAACTTCTTAAAACATGCGAACTTCTTGAAAACCACTACTTAGACATGCAAGAT
ATTGAATTTACGATTGAAAAAGGAAAACTTTATGTCTTACAAACAAGAAGCGGGAAACGAACAGCTAAGGCAGCTATCCA
AACAGCCGTTGATTTTGTTCATGAAGGAAAAATCACTCGAGAAGAAGCCATCATGCGAGTGGAAACGAAGCAACTACACC
AATTACTTCATCCAGCCTTTCATGAAAGCGCTCTTAAAAATGGTCACGTAATCGCGTCTGGTTTACCTGCCAGCCCAGGT
GCTGCAACAGGTCAAATTTATTTTGAAGCAAAAGAAGCAGTCCAAGCAGCCGAACGCGGAATTTCTGTCATTCTTGTACG
GAACGAGACTTCTCCTGAAGATATTGAAGGCATGGCAAGAAGTAATGCTATTTTAACCGCACATGGTGGAATGACTTCTC
ACGCAGCCGTTGTTGCTCGTGGAATGGGCAAATGTTGTATAGCAGGCTGTTCTGAATTAACCATCAATGAAAAGGAAAAA
ACAATTACCCTTAAAACTGGCGAAAAGCTTTACGAAGGTGACTATCTTTCTCTTGATGGCAGTTCCGGCAATATTTACCT
TGGCGAAATTGCACTCACAGAAGCGTCTATTGGCGGTCATTTTGATGAATTAATGGGCTGGGCTGATGCAGCGAAAAAAC
TGATGATTCGTGTTAATGCAGACACACCTACTGATTTTAAAAAAGCACTTTTATTTGGCGCAGAAGGTATTGGACTTTGC
CGCACAGAGCATATGTTTTTTGATGAAAAGCGGATTCCATATGTAAGACAAATGATTTTAGCAGAGTCCTTAAAAGAACG
TGAATCTGTTTTAACCATTTTAAAAGAAATGCAAAAAGCGGATTTTAGTGAGTTGTTCCGAATCGCAGAAGGTCGTTCAG
TTAATATTCGTTTACTTGATCCGCCATTACATGAATTCTTACCAAAAACTGACCATGAAATCGAACAATTAGCACAAGAC
ATGAACCGAACTGTTCCTCAAATAAGAAAGCGAATAGAAGCACTTGCAGAAGCTAATCCAATGCTTGGTCATCGCGGTTG
CCGACTTGCCATTACTTTCCCAGAAATTTATCGTATGCAGGCCGAAGCAATTATGGAAAGCGCCGTTATCGTTCATGATG
AAGGAATCTCTGTTCACCCAGAAATTATGATTCCACTTATTGCTACTAAAAGTGAACTAAGCTATATAAAAAAAGAAATA
AAACAAGTAATCCATGCCATTTTTGATAGAGAAAGAATGGTGCTACCTTATGATATTGGTACGATGATAGAAATTCCTCG
TGCTTGCGTAACTGCAGATGAAATCGCCGAGGAAGCACAATTCTTTAGCTTCGGGACAAATGATTTAACCCAACTAACTT
ATGGTTTCTCTCGTGATGATGCTACCAAATTCCTAGCTGACTATTACGAGAAAGATATTTTAGCAAAAGATCCATTTATG
ACAATTGATAAAGCCGGGGTTGGTGCTTTAGTAGAGATGGCTGTTACTCGAGGACGGATGACGCATGAACATTTAAAAAT
GGGTGTTTGTGGCGAACATGGTGGAGATCCAGATTCTATCCAATTCTTCCATCAATTAGGACTAACCTATGTTTCTTGCT
CTCCTTATCGTGTACCTATTGCACGACTAGCAGCAGCTCAAGCAGCATTAGGCACTAAGCAATTAGTAGCTACTCTATAA

Upstream 100 bases:

>100_bases
CTGCCAGGTCATCCATGTAGAAGACAAAGCAATAGAAGAAACCGCTGCCCTAATCACGGAAATTATCACGAGTTACCACT
AATTAGAAGAGGTGAATAAT

Downstream 100 bases:

>100_bases
AAAATCCAGATGGCAATCGGTAAGACTGCCATCTGGATTTTTTCATATTTATTTTTCACAAATCGCAAAATAATTGCCTT
CAATATCCGCAAAATTAAAG

Product: pyruvate phosphate dikinase

Products: NA

Alternate protein names: Pyruvate, orthophosphate dikinase [H]

Number of amino acids: Translated: 879; Mature: 879

Protein sequence:

>879_residues
MRKFVYQFSEGSKDMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTTGNKHLSEEIFEEVKIHLSKLETQTGKVF
GSTENPLLVSVRSGAPFSMPGMMDTVLNLGLNDSAARGLADLTGDARSAYDSYRRFIQMFGDVVFEIPSYQFEQALSRIK
KANNYLLDTELTADDLTELIDAYKLIFSQATGNDFPQNPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASLGTAVNIQA
MVFGNTGESSGTGITFTRNPSTGEKEVFGEFLLNAQGEDVVAGIRTPEPISALQMRMPMVYNELLKTCELLENHYLDMQD
IEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVHEGKITREEAIMRVETKQLHQLLHPAFHESALKNGHVIASGLPASPG
AATGQIYFEAKEAVQAAERGISVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCSELTINEKEK
TITLKTGEKLYEGDYLSLDGSSGNIYLGEIALTEASIGGHFDELMGWADAAKKLMIRVNADTPTDFKKALLFGAEGIGLC
RTEHMFFDEKRIPYVRQMILAESLKERESVLTILKEMQKADFSELFRIAEGRSVNIRLLDPPLHEFLPKTDHEIEQLAQD
MNRTVPQIRKRIEALAEANPMLGHRGCRLAITFPEIYRMQAEAIMESAVIVHDEGISVHPEIMIPLIATKSELSYIKKEI
KQVIHAIFDRERMVLPYDIGTMIEIPRACVTADEIAEEAQFFSFGTNDLTQLTYGFSRDDATKFLADYYEKDILAKDPFM
TIDKAGVGALVEMAVTRGRMTHEHLKMGVCGEHGGDPDSIQFFHQLGLTYVSCSPYRVPIARLAAAQAALGTKQLVATL

Sequences:

>Translated_879_residues
MRKFVYQFSEGSKDMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTTGNKHLSEEIFEEVKIHLSKLETQTGKVF
GSTENPLLVSVRSGAPFSMPGMMDTVLNLGLNDSAARGLADLTGDARSAYDSYRRFIQMFGDVVFEIPSYQFEQALSRIK
KANNYLLDTELTADDLTELIDAYKLIFSQATGNDFPQNPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASLGTAVNIQA
MVFGNTGESSGTGITFTRNPSTGEKEVFGEFLLNAQGEDVVAGIRTPEPISALQMRMPMVYNELLKTCELLENHYLDMQD
IEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVHEGKITREEAIMRVETKQLHQLLHPAFHESALKNGHVIASGLPASPG
AATGQIYFEAKEAVQAAERGISVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCSELTINEKEK
TITLKTGEKLYEGDYLSLDGSSGNIYLGEIALTEASIGGHFDELMGWADAAKKLMIRVNADTPTDFKKALLFGAEGIGLC
RTEHMFFDEKRIPYVRQMILAESLKERESVLTILKEMQKADFSELFRIAEGRSVNIRLLDPPLHEFLPKTDHEIEQLAQD
MNRTVPQIRKRIEALAEANPMLGHRGCRLAITFPEIYRMQAEAIMESAVIVHDEGISVHPEIMIPLIATKSELSYIKKEI
KQVIHAIFDRERMVLPYDIGTMIEIPRACVTADEIAEEAQFFSFGTNDLTQLTYGFSRDDATKFLADYYEKDILAKDPFM
TIDKAGVGALVEMAVTRGRMTHEHLKMGVCGEHGGDPDSIQFFHQLGLTYVSCSPYRVPIARLAAAQAALGTKQLVATL
>Mature_879_residues
MRKFVYQFSEGSKDMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTTGNKHLSEEIFEEVKIHLSKLETQTGKVF
GSTENPLLVSVRSGAPFSMPGMMDTVLNLGLNDSAARGLADLTGDARSAYDSYRRFIQMFGDVVFEIPSYQFEQALSRIK
KANNYLLDTELTADDLTELIDAYKLIFSQATGNDFPQNPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASLGTAVNIQA
MVFGNTGESSGTGITFTRNPSTGEKEVFGEFLLNAQGEDVVAGIRTPEPISALQMRMPMVYNELLKTCELLENHYLDMQD
IEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVHEGKITREEAIMRVETKQLHQLLHPAFHESALKNGHVIASGLPASPG
AATGQIYFEAKEAVQAAERGISVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCSELTINEKEK
TITLKTGEKLYEGDYLSLDGSSGNIYLGEIALTEASIGGHFDELMGWADAAKKLMIRVNADTPTDFKKALLFGAEGIGLC
RTEHMFFDEKRIPYVRQMILAESLKERESVLTILKEMQKADFSELFRIAEGRSVNIRLLDPPLHEFLPKTDHEIEQLAQD
MNRTVPQIRKRIEALAEANPMLGHRGCRLAITFPEIYRMQAEAIMESAVIVHDEGISVHPEIMIPLIATKSELSYIKKEI
KQVIHAIFDRERMVLPYDIGTMIEIPRACVTADEIAEEAQFFSFGTNDLTQLTYGFSRDDATKFLADYYEKDILAKDPFM
TIDKAGVGALVEMAVTRGRMTHEHLKMGVCGEHGGDPDSIQFFHQLGLTYVSCSPYRVPIARLAAAQAALGTKQLVATL

Specific function: Catalyzes the reversible phosphorylation of pyruvate and phosphate. In E.histolytica and C.symbiosus, PPDK functions in the direction of ATP synthesis [H]

COG id: COG0574

COG function: function code G; Phosphoenolpyruvate synthase/pyruvate phosphate dikinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PEP-utilizing enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1787994, Length=782, Percent_Identity=23.4015345268542, Blast_Score=103, Evalue=5e-23,
Organism=Escherichia coli, GI1788756, Length=453, Percent_Identity=24.5033112582781, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788726, Length=332, Percent_Identity=25, Blast_Score=90, Evalue=7e-19,
Organism=Escherichia coli, GI48994992, Length=466, Percent_Identity=25.1072961373391, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1789193, Length=441, Percent_Identity=21.3151927437642, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR008279
- InterPro:   IPR018274
- InterPro:   IPR023151
- InterPro:   IPR000121
- InterPro:   IPR002192
- InterPro:   IPR010121
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00391 PEP-utilizers; PF02896 PEP-utilizers_C; PF01326 PPDK_N [H]

EC number: =2.7.9.1 [H]

Molecular weight: Translated: 97262; Mature: 97262

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00370 PEP_ENZYMES_PHOS_SITE ; PS00742 PEP_ENZYMES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFVYQFSEGSKDMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTTGNKHLSEE
CCCEEEEHHCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
IFEEVKIHLSKLETQTGKVFGSTENPLLVSVRSGAPFSMPGMMDTVLNLGLNDSAARGLA
HHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCHHHCCHH
DLTGDARSAYDSYRRFIQMFGDVVFEIPSYQFEQALSRIKKANNYLLDTELTADDLTELI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DAYKLIFSQATGNDFPQNPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASLGTAVNIQA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
MVFGNTGESSGTGITFTRNPSTGEKEVFGEFLLNAQGEDVVAGIRTPEPISALQMRMPMV
EEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
YNELLKTCELLENHYLDMQDIEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVHEGKITR
HHHHHHHHHHHHHHCCCHHHCEEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCH
EEAIMRVETKQLHQLLHPAFHESALKNGHVIASGLPASPGAATGQIYFEAKEAVQAAERG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEHHHHHHHHHCC
ISVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCSELTINEKEK
EEEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCEECCCCC
TITLKTGEKLYEGDYLSLDGSSGNIYLGEIALTEASIGGHFDELMGWADAAKKLMIRVNA
EEEEECCCCHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCEEEEEECC
DTPTDFKKALLFGAEGIGLCRTEHMFFDEKRIPYVRQMILAESLKERESVLTILKEMQKA
CCCHHHHHHHHHCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFSELFRIAEGRSVNIRLLDPPLHEFLPKTDHEIEQLAQDMNRTVPQIRKRIEALAEANP
CHHHHHHHHCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLGHRGCRLAITFPEIYRMQAEAIMESAVIVHDEGISVHPEIMIPLIATKSELSYIKKEI
CCCCCCCEEEEECHHHHHHHHHHHHHHHEEEECCCCEECCCEEEEEEECHHHHHHHHHHH
KQVIHAIFDRERMVLPYDIGTMIEIPRACVTADEIAEEAQFFSFGTNDLTQLTYGFSRDD
HHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCH
ATKFLADYYEKDILAKDPFMTIDKAGVGALVEMAVTRGRMTHEHLKMGVCGEHGGDPDSI
HHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
QFFHQLGLTYVSCSPYRVPIARLAAAQAALGTKQLVATL
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHCC
>Mature Secondary Structure
MRKFVYQFSEGSKDMKNLLGGKGANLAEMTNIGLPVPPGFIISTDACNDYTTGNKHLSEE
CCCEEEEHHCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHH
IFEEVKIHLSKLETQTGKVFGSTENPLLVSVRSGAPFSMPGMMDTVLNLGLNDSAARGLA
HHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCCCCCHHHHHHHHCCCCCHHHCCHH
DLTGDARSAYDSYRRFIQMFGDVVFEIPSYQFEQALSRIKKANNYLLDTELTADDLTELI
HHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHH
DAYKLIFSQATGNDFPQNPLEQLRLAIIAVFDSWMNPRAVIYRRLHDIDASLGTAVNIQA
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEE
MVFGNTGESSGTGITFTRNPSTGEKEVFGEFLLNAQGEDVVAGIRTPEPISALQMRMPMV
EEEECCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHH
YNELLKTCELLENHYLDMQDIEFTIEKGKLYVLQTRSGKRTAKAAIQTAVDFVHEGKITR
HHHHHHHHHHHHHHCCCHHHCEEEEECCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCH
EEAIMRVETKQLHQLLHPAFHESALKNGHVIASGLPASPGAATGQIYFEAKEAVQAAERG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEHHHHHHHHHCC
ISVILVRNETSPEDIEGMARSNAILTAHGGMTSHAAVVARGMGKCCIAGCSELTINEKEK
EEEEEEECCCCCHHHHHHHHCCEEEEECCCCCHHHHHHHHCCCHHHHCCCCCCEECCCCC
TITLKTGEKLYEGDYLSLDGSSGNIYLGEIALTEASIGGHFDELMGWADAAKKLMIRVNA
EEEEECCCCHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCEEEEEECC
DTPTDFKKALLFGAEGIGLCRTEHMFFDEKRIPYVRQMILAESLKERESVLTILKEMQKA
CCCHHHHHHHHHCCCCCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFSELFRIAEGRSVNIRLLDPPLHEFLPKTDHEIEQLAQDMNRTVPQIRKRIEALAEANP
CHHHHHHHHCCCEEEEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MLGHRGCRLAITFPEIYRMQAEAIMESAVIVHDEGISVHPEIMIPLIATKSELSYIKKEI
CCCCCCCEEEEECHHHHHHHHHHHHHHHEEEECCCCEECCCEEEEEEECHHHHHHHHHHH
KQVIHAIFDRERMVLPYDIGTMIEIPRACVTADEIAEEAQFFSFGTNDLTQLTYGFSRDD
HHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCH
ATKFLADYYEKDILAKDPFMTIDKAGVGALVEMAVTRGRMTHEHLKMGVCGEHGGDPDSI
HHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHH
QFFHQLGLTYVSCSPYRVPIARLAAAQAALGTKQLVATL
HHHHHCCCEEEECCCCCCHHHHHHHHHHHHCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2176881; 6257292; 11695893; 11468288; 8610096; 9753432 [H]