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The map label for this gene is 116873141

Identifier: 116873141

GI number: 116873141

Start: 1745160

End: 1745804

Strand: Direct

Name: 116873141

Synonym: lwe1725

Alternate gene names: NA

Gene position: 1745160-1745804 (Clockwise)

Preceding gene: 116873134

Following gene: 116873143

Centisome position: 62.01

GC content: 33.18

Gene sequence:

>645_bases
ATGGAAGGAGTAGGAAATAAAGTGATTGTTTTAGCAGGAATGATTGGCGCTGGAAAAAGTAGTTATACAGAGCTAATTGC
AAATGAACTTGGAACAAAAGCATTTTATGAAAGCATTAAGGATAATCGGATCTTAGAAATGTTTTATGATGACCCAAAAA
GATGGGCTTTTGCCTTACAAATATATTTTTTAAATACTCGTTTTCGTAGTATCAAAGCCGCGTTAACGGATCAAAATAAT
GTGCTAGATCGGAGCATTTATGAAGACGCCCTTTTTACACAAATTAATTTTGAAGAAGGTAATATTTCTGAACCTGAGAT
GGATACATATCTTGATTTACTCGACAATATGATGGAAGAACTTGCTTATATGCCAAAAAAAGCACCGGATTTGTTAATTT
ATTTACGTGGGAGTTTGGACACGGTTTTAAGTAGAATTTCTCTTCGGGGACGTCCTTACGAACAAATTGGTGCTAATCCT
GGTTTACTTGAATATTATAAACATCTCCATAGTCGTTATGATAGCTGGTTTGCATCTTATGATAAGAGTGAAACACTTGT
AATTAATATTGACGAAATTGATATTAATAAACCAAATGACGCAGATTATGTCATGCAACTTATTCATGAAAAATTAAAAC
GCTAA

Upstream 100 bases:

>100_bases
TCCCTCATTTCTTCTCTTTTATCGTACAAAAAATCTCCTTATTAAGCAAATTAGTAGTATAATGAACAAATAGTCGACCA
AAAAGGAGGCTGCTCGAGTT

Downstream 100 bases:

>100_bases
AACAGCACGTACTGTTTTAGCGTTTTTTTAATTTATTTCGCCTAATTCTTTCTTCTTTTTACGAATAGCAAGGGTTGCAT
TTAGCTCTCCGCCAATCATT

Product: deoxynucleoside kinase family protein

Products: NA

Alternate protein names: DGK; DGUO kinase; Deoxynucleoside kinase complex I F-component [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MEGVGNKVIVLAGMIGAGKSSYTELIANELGTKAFYESIKDNRILEMFYDDPKRWAFALQIYFLNTRFRSIKAALTDQNN
VLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQIGANP
GLLEYYKHLHSRYDSWFASYDKSETLVINIDEIDINKPNDADYVMQLIHEKLKR

Sequences:

>Translated_214_residues
MEGVGNKVIVLAGMIGAGKSSYTELIANELGTKAFYESIKDNRILEMFYDDPKRWAFALQIYFLNTRFRSIKAALTDQNN
VLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQIGANP
GLLEYYKHLHSRYDSWFASYDKSETLVINIDEIDINKPNDADYVMQLIHEKLKR
>Mature_214_residues
MEGVGNKVIVLAGMIGAGKSSYTELIANELGTKAFYESIKDNRILEMFYDDPKRWAFALQIYFLNTRFRSIKAALTDQNN
VLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEELAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQIGANP
GLLEYYKHLHSRYDSWFASYDKSETLVINIDEIDINKPNDADYVMQLIHEKLKR

Specific function: DGK/DAK plays an essential role in generating the deoxyribonucleotide precursors, dGTP and dATP, for DNA metabolism [H]

COG id: COG1428

COG function: function code F; Deoxynucleoside kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DCK/DGK family [H]

Homologues:

Organism=Homo sapiens, GI4503269, Length=221, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17738037, Length=205, Percent_Identity=25.8536585365854, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002624 [H]

Pfam domain/function: PF01712 dNK [H]

EC number: =2.7.1.113 [H]

Molecular weight: Translated: 24777; Mature: 24777

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGVGNKVIVLAGMIGAGKSSYTELIANELGTKAFYESIKDNRILEMFYDDPKRWAFALQ
CCCCCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCHHEEEEEE
IYFLNTRFRSIKAALTDQNNVLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEE
EEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHH
LAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQIGANPGLLEYYKHLHSRYDSWFASY
HHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHC
DKSETLVINIDEIDINKPNDADYVMQLIHEKLKR
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEGVGNKVIVLAGMIGAGKSSYTELIANELGTKAFYESIKDNRILEMFYDDPKRWAFALQ
CCCCCCEEEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCHHEEEEEE
IYFLNTRFRSIKAALTDQNNVLDRSIYEDALFTQINFEEGNISEPEMDTYLDLLDNMMEE
EEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHHHHH
LAYMPKKAPDLLIYLRGSLDTVLSRISLRGRPYEQIGANPGLLEYYKHLHSRYDSWFASY
HHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHC
DKSETLVINIDEIDINKPNDADYVMQLIHEKLKR
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7896798; 8172906 [H]