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The map label for this gene is mvaS [H]

Identifier: 116872848

GI number: 116872848

Start: 1426202

End: 1427368

Strand: Direct

Name: mvaS [H]

Synonym: lwe1432

Alternate gene names: 116872848

Gene position: 1426202-1427368 (Clockwise)

Preceding gene: 116872843

Following gene: 116872854

Centisome position: 50.68

GC content: 35.05

Gene sequence:

>1167_bases
ATGAAAATTGGAATTGATAAAATAGGTTTTTATACTCCTTCGTTTTATGTTGATATGACAGAACTTGCTGAAGCTAGAAA
TATTGACCCAAATAAATTTACCATTGGAATTGGTCAAGATAAAATGGCTTTTGCCCCTATCAGCCAAGATTCCGTAACAA
TGGGCGCTAATGCAGCGTTACAAATTTTAAATGAAGAAGATTTGAAAAAAATTGATTTAGTTATTTTAGCAACAGAATCG
GGAATTGACGAATCAAAAGCTGGAGCGGTTTATATTCATCGTTTACTAGGCATTCAACCATTCTCACGTGCCATTGAAAT
AAAAGAAGCTTGTTACGGAGCTACAGCTGGTATTAATTTAGCCAAAGATTACGTAGCAAAACATCCTGAAAGTAAAGTGC
TTGTAATCGGCTCTGATATTGCTCGTTATGGCCTTGAGACTGGCGGTGAAGCAACACAAGGAGCTGGAGCAGTTGCGATG
GTTATTTCGGCTAATCCACGTTGCATTACACTAGAAGATGATAATGTGTTTTATACGGAAGATATTATGGATTTCTGGCG
TCCAGTCTATTCTGAGTATGCATGTGTAGAAGGTAAATACTCAACTGAACAATATATCCATTTCTTTCAAACCATTTGGG
AGAAATATCGAGAGAAATTCGGTAAGAAATTAGATGATTTTGCAGCTATCTGTTTCCATTTACCTTATACAAAAATGGGG
AAAAAAGCACTAGATACCATTATTGAAACTGCTCCGAGTGATGTACAAGAAAGATTGCTAGAAAATTATCGCTTAAGTAC
CTTATATAGCCGTAGTGTTGGTAATATTTATACGGGTTCCTTATATTTAAGTTTTATTTCTTTACTAGAAAATCAAGCGA
ATTTACAAGCAAATGATAAGATTGGATTCTTTAGTTATGGTTCCGGAGCTGTTGGCGAATTTTTCCATGGAACGCTTCAA
CCAGATTTTAAAAAGTATATTCGTACAGAGGAACATGCTGAATTATTAGCAAATCGTACGAAACTCTCTATTTCAGACTA
CGAAACGAAATTTAAACAACAACTACCAAAAGATGGCTCTACTTTTGAAATTGATCCTTCGAGCGACCCTGCACCAATTG
TTTTAACAGGTATTCAAGATCATAAACGTCAATATATAAAAAAATAA

Upstream 100 bases:

>100_bases
TAAAAACTCACTAGATTAAGCCCAATGTATTGTATTTTAAGCATTTTTCTACTAAAATTGAAGTACTTACAAATAAAATA
TAAAGGACTTGAGACTACAA

Downstream 100 bases:

>100_bases
CACTAAAAAACCGACTAAGCTAAATCAGCTAGTCGGTTTTACTTTGAGTTGTTTGAATTTTCCCTTGGAGAAAACCCTGA
TGATAATATATCCAAGCATT

Product: hydroxymethylglutaryl-CoA synthase

Products: (S)-3-hydroxy-3-methylglutaryl-CoA; CoA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKIGIDKIGFYTPSFYVDMTELAEARNIDPNKFTIGIGQDKMAFAPISQDSVTMGANAALQILNEEDLKKIDLVILATES
GIDESKAGAVYIHRLLGIQPFSRAIEIKEACYGATAGINLAKDYVAKHPESKVLVIGSDIARYGLETGGEATQGAGAVAM
VISANPRCITLEDDNVFYTEDIMDFWRPVYSEYACVEGKYSTEQYIHFFQTIWEKYREKFGKKLDDFAAICFHLPYTKMG
KKALDTIIETAPSDVQERLLENYRLSTLYSRSVGNIYTGSLYLSFISLLENQANLQANDKIGFFSYGSGAVGEFFHGTLQ
PDFKKYIRTEEHAELLANRTKLSISDYETKFKQQLPKDGSTFEIDPSSDPAPIVLTGIQDHKRQYIKK

Sequences:

>Translated_388_residues
MKIGIDKIGFYTPSFYVDMTELAEARNIDPNKFTIGIGQDKMAFAPISQDSVTMGANAALQILNEEDLKKIDLVILATES
GIDESKAGAVYIHRLLGIQPFSRAIEIKEACYGATAGINLAKDYVAKHPESKVLVIGSDIARYGLETGGEATQGAGAVAM
VISANPRCITLEDDNVFYTEDIMDFWRPVYSEYACVEGKYSTEQYIHFFQTIWEKYREKFGKKLDDFAAICFHLPYTKMG
KKALDTIIETAPSDVQERLLENYRLSTLYSRSVGNIYTGSLYLSFISLLENQANLQANDKIGFFSYGSGAVGEFFHGTLQ
PDFKKYIRTEEHAELLANRTKLSISDYETKFKQQLPKDGSTFEIDPSSDPAPIVLTGIQDHKRQYIKK
>Mature_388_residues
MKIGIDKIGFYTPSFYVDMTELAEARNIDPNKFTIGIGQDKMAFAPISQDSVTMGANAALQILNEEDLKKIDLVILATES
GIDESKAGAVYIHRLLGIQPFSRAIEIKEACYGATAGINLAKDYVAKHPESKVLVIGSDIARYGLETGGEATQGAGAVAM
VISANPRCITLEDDNVFYTEDIMDFWRPVYSEYACVEGKYSTEQYIHFFQTIWEKYREKFGKKLDDFAAICFHLPYTKMG
KKALDTIIETAPSDVQERLLENYRLSTLYSRSVGNIYTGSLYLSFISLLENQANLQANDKIGFFSYGSGAVGEFFHGTLQ
PDFKKYIRTEEHAELLANRTKLSISDYETKFKQQLPKDGSTFEIDPSSDPAPIVLTGIQDHKRQYIKK

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Homo sapiens, GI5031751, Length=455, Percent_Identity=26.3736263736264, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI148298764, Length=370, Percent_Identity=28.9189189189189, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI148298677, Length=370, Percent_Identity=28.9189189189189, Blast_Score=115, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17560126, Length=360, Percent_Identity=26.6666666666667, Blast_Score=124, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323509, Length=400, Percent_Identity=26.25, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24654139, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24654137, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24654133, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24654135, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17933694, Length=400, Percent_Identity=28.5, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: 2.3.3.10

Molecular weight: Translated: 43444; Mature: 43444

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIDKIGFYTPSFYVDMTELAEARNIDPNKFTIGIGQDKMAFAPISQDSVTMGANAAL
CCCCCCCCCCCCCCCEEEHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCEECCCCHHH
QILNEEDLKKIDLVILATESGIDESKAGAVYIHRLLGIQPFSRAIEIKEACYGATAGINL
EECCHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHH
AKDYVAKHPESKVLVIGSDIARYGLETGGEATQGAGAVAMVISANPRCITLEDDNVFYTE
HHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCEEEHH
DIMDFWRPVYSEYACVEGKYSTEQYIHFFQTIWEKYREKFGKKLDDFAAICFHLPYTKMG
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
KKALDTIIETAPSDVQERLLENYRLSTLYSRSVGNIYTGSLYLSFISLLENQANLQANDK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCC
IGFFSYGSGAVGEFFHGTLQPDFKKYIRTEEHAELLANRTKLSISDYETKFKQQLPKDGS
EEEEECCCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCC
TFEIDPSSDPAPIVLTGIQDHKRQYIKK
EEEECCCCCCCCEEEECCHHHHHHHHCC
>Mature Secondary Structure
MKIGIDKIGFYTPSFYVDMTELAEARNIDPNKFTIGIGQDKMAFAPISQDSVTMGANAAL
CCCCCCCCCCCCCCCEEEHHHHHHHCCCCCCEEEEEECCCCEEECCCCCCCEECCCCHHH
QILNEEDLKKIDLVILATESGIDESKAGAVYIHRLLGIQPFSRAIEIKEACYGATAGINL
EECCHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHH
AKDYVAKHPESKVLVIGSDIARYGLETGGEATQGAGAVAMVISANPRCITLEDDNVFYTE
HHHHHHCCCCCCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCEEEHH
DIMDFWRPVYSEYACVEGKYSTEQYIHFFQTIWEKYREKFGKKLDDFAAICFHLPYTKMG
HHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
KKALDTIIETAPSDVQERLLENYRLSTLYSRSVGNIYTGSLYLSFISLLENQANLQANDK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCCCCC
IGFFSYGSGAVGEFFHGTLQPDFKKYIRTEEHAELLANRTKLSISDYETKFKQQLPKDGS
EEEEECCCCCHHHHHCCCCCHHHHHHHCCHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCC
TFEIDPSSDPAPIVLTGIQDHKRQYIKK
EEEECCCCCCCCEEEECCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acetyl-CoA; H2O; acetoacetyl-CoA

Specific reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]