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The map label for this gene is uppS [H]

Identifier: 116872746

GI number: 116872746

Start: 1319947

End: 1320705

Strand: Direct

Name: uppS [H]

Synonym: lwe1330

Alternate gene names: 116872746

Gene position: 1319947-1320705 (Clockwise)

Preceding gene: 116872745

Following gene: 116872747

Centisome position: 46.9

GC content: 36.23

Gene sequence:

>759_bases
ATGTTTAAAAAGCTATTTCGACAAGATGAAAATATATTAAATAGTGAACTTGCAGAAGATTTGCCTATTCCAAGTCACGT
TGCTATTATTATGGATGGAAATGGAAGATGGGCAAAAAAACGTTTCTTACCAAGAATTGCAGGACATAAAGAAGGTATGG
ATGTAGTCAAGCGTGTTACACGTTATGCGAGTGCGATTGGTATTGATGTATTAACGCTTTATGCATTTTCAACTGAAAAC
TGGAAGCGACCTACAGATGAAGTGGATTTTTTAATGAAACTACCTGTAGAATTTTTTGACTCATTTGTACCAGAGTTGAT
TGAAGAAAATGTTCGAGTTAACGTAATGGGTTACAGAGAAAATCTACCCGAACACACAATGCGAGCTGTAGAAAAAGCTA
TAGCTGATACGTCTCACTGCACAGGACTGACACTTAACTTTGCACTTAACTATGGCGGTCGGTCGGAAATCATAACTGCT
GCAAAAGAAGCCATGAAAGAATTAGCTTTAGAAGGTAAGTCATCTGAGGATTTAACGGAAGAAATTTTAAATAACCATTT
AATGAGTAGTGGTCTTGGAGATCCTGATTTACTCATTCGAACTAGTGGCGAACTAAGATTAAGTAATTTTATGCTATGGC
AATTAGCTTATAGTGAATTTTATTTTACAGAAACACATTGGCCTGATTTTTCAAAAGAAGATTTTTTACAAGCGATTATT
GAGTATCAAAACCGAACGCGTCGCTTTGGAGGGCTCTAG

Upstream 100 bases:

>100_bases
CTCATGTGTTCACATGGAATTTTTAGTACATTAATTGATTCTTTTTTGTTATTATAGGTATAGACATGCTCTAAGAAGTG
TATCAATTGGAGGATTTATG

Downstream 100 bases:

>100_bases
GGAGGAAAGAAGATTGAAAACGAGAATTATTACTGCAGTTGTTGCGCTTATATTTTTCATTCCGTTTGTTGTTTATGGAG
GAATTCCGTTTGAATTATTA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MFKKLFRQDENILNSELAEDLPIPSHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYASAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPEHTMRAVEKAIADTSHCTGLTLNFALNYGGRSEIITA
AKEAMKELALEGKSSEDLTEEILNNHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTETHWPDFSKEDFLQAII
EYQNRTRRFGGL

Sequences:

>Translated_252_residues
MFKKLFRQDENILNSELAEDLPIPSHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYASAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPEHTMRAVEKAIADTSHCTGLTLNFALNYGGRSEIITA
AKEAMKELALEGKSSEDLTEEILNNHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTETHWPDFSKEDFLQAII
EYQNRTRRFGGL
>Mature_252_residues
MFKKLFRQDENILNSELAEDLPIPSHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVTRYASAIGIDVLTLYAFSTEN
WKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRENLPEHTMRAVEKAIADTSHCTGLTLNFALNYGGRSEIITA
AKEAMKELALEGKSSEDLTEEILNNHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTETHWPDFSKEDFLQAII
EYQNRTRRFGGL

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=35.5555555555556, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=35.5555555555556, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI1786371, Length=237, Percent_Identity=46.8354430379747, Blast_Score=215, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=36.2068965517241, Blast_Score=136, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319474, Length=231, Percent_Identity=32.9004329004329, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=31.9444444444444, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=37.9464285714286, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28935; Mature: 28935

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLFRQDENILNSELAEDLPIPSHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVT
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHH
RYASAIGIDVLTLYAFSTENWKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRE
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEHHH
NLPEHTMRAVEKAIADTSHCTGLTLNFALNYGGRSEIITAAKEAMKELALEGKSSEDLTE
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
EILNNHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTETHWPDFSKEDFLQAII
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHH
EYQNRTRRFGGL
HHHHHHHHCCCC
>Mature Secondary Structure
MFKKLFRQDENILNSELAEDLPIPSHVAIIMDGNGRWAKKRFLPRIAGHKEGMDVVKRVT
CCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHH
RYASAIGIDVLTLYAFSTENWKRPTDEVDFLMKLPVEFFDSFVPELIEENVRVNVMGYRE
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEHHH
NLPEHTMRAVEKAIADTSHCTGLTLNFALNYGGRSEIITAAKEAMKELALEGKSSEDLTE
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
EILNNHLMSSGLGDPDLLIRTSGELRLSNFMLWQLAYSEFYFTETHWPDFSKEDFLQAII
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHH
EYQNRTRRFGGL
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]