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The map label for this gene is uvrC [H]

Identifier: 116872605

GI number: 116872605

Start: 1200751

End: 1202562

Strand: Direct

Name: uvrC [H]

Synonym: lwe1189

Alternate gene names: 116872605

Gene position: 1200751-1202562 (Clockwise)

Preceding gene: 116872604

Following gene: 116872606

Centisome position: 42.67

GC content: 37.69

Gene sequence:

>1812_bases
ATGTCTTCTGAACATATCCAAAATAAATTAGCGCTTCTGCCAGACCAACCTGGTTGCTATTTGATGAAAGATAGACAAGG
AACCATTATTTACGTTGGGAAAGCAAAAGTGTTGAAAAATCGTGTACGTTCTTATTTTTCAGGGACACATGATAGTAAAA
CACAACGATTAGTTCAAGAAATTGTGGACTTTGAATATATTGTTACTTCATCCAATGTAGAAGCGTTACTACTAGAAATC
AATTTAATCAAAAAACATGACCCGCGTTTTAATATACGTTTAAAAGATGATAAAACGTATCCATTTATAAAAATTACTAA
CGAACGACATCCGCGTTTGATTATTACCCGTCAAGTCAAGAAAGATAAAGGGAAATATTTCGGACCATATCCAAATGTCT
ATGCTGCAAATGAAGTGAAACGTATTTTAGATCGGCTATATCCGCTTCGAAAATGTAGCACGTTACCAAATAAAGTATGT
TTATATTATCACCTCGGACAATGTCTTGCACCATGCGTATTTGACGTGGAGGCAAGTAAATATAAAGAAATGCAAGATGA
AATTGTGGCATTCTTAAATGGCGGCTATAAAACCGTCAAAAATGACTTAATGAAAAAAATGCAAGTGGCCGCAGAAAATA
TGGAATTTGAAAAAGCAGGAGAATTTCGCGACCAAATTAACGCAATCGAAACAACGATGGAAAAACAAAAAATGACAATG
AATGATTTTGTTGACCGTGATGTATTTGGTTATGCTATTGATAAAGGCTGGATGTGTGTCCAAGTATTCTTCATCCGTCA
AGGAAAACTCATTGAGCGCGATGTTTCGCAGTTTCCATTTTACAATGATGCGGATGAAGATTTCCTCACATTTATTGGTC
AGTTTTATCAAAAAGCAAATCATATTCCGCCAAAAGAAATCTATTTACCAGATGATGTTGATAGCGAAGCCGTTCAAGCG
GTTGTTCCCGACACAAAAATCATCGTACCACAACGCGGAAACAAAAAAGAACTTGTAAAACTAGCTTATAAAAATGCCAA
AATCGCCTTAAATGAAAAATTCATGTTACTAGAACGCAATGAAGAACGAACAGTCGGTGCGGTAGAACGGCTTGGTGAAG
CAATGGGAATTCCAACACCATCACGCGTGGAAGCTTTTGACAACTCCAACATTCACGGTACAGACCCAGTTTCGGCCATG
GTCACATTTCTTGATGGCAAACCAAGTAAAAATGATTACCGGAAATACAAAATCAAAACCGTGGAAGGTCCGGATGATTA
TGCTACGATGCGTGAAGTTATTCGAAGACGTTACTGGAGAGTGCTAAAAGAGAGACTACCAATGCCTGATTTGATACTAA
TTGATGGTGGTAAAGGCCAAATTGACAGCGCTAAAGACGTCCTTATAAATGAATTAGGCTTAGACATACCAGTAGCAGGA
CTTGCCAAAGACGACAAACACCGTACCAGTCAACTATTATTTGGTGATCCACTAGAAATAGTTCCACTTGAGAGAAACAG
CCAAGAATTCTATTTACTGCAACGAATGCAAGATGAGGTCCATCGCTTTGCCATCACATTCCATCGCCAATTACGTAGCA
AAACAGGTTTCCAATCCATTCTTGATGGCATTCCAGGCGTAGGTCCGGGACGTAAGAAAAAACTACTCAAACATTTTGGT
TCCATGAAAAAATTAAAAGAAGCTTCTGTGGAAGAAATCAAAGAAGCTGGTGTTCCTATGAATGTTGCAGAAGAAGTGCA
TAAACACATTACCACTTTCAATGAAAAAGCCAAAAATACGGAACAAAAATAA

Upstream 100 bases:

>100_bases
TGAAGTCATCAACAAATACGTTTAAAATTATGCTAAAATGAAAGAAGCTTAGGACTAACATTCTAAGCTTCTTTTTAAAT
GTATAACTGGAGTTGATAAA

Downstream 100 bases:

>100_bases
TTTTAGTTGCAAATACCAGTTAGGCAATTTAGCTTCAATAGATTTAAAAACACCAATGACTCTTAGGTTATTGGTGTTTT
TATACATTCAAGTTATTTTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKVLKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEI
NLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVC
LYYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQVAAENMEFEKAGEFRDQINAIETTMEKQKMTM
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQA
VVPDTKIIVPQRGNKKELVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAM
VTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKERLPMPDLILIDGGKGQIDSAKDVLINELGLDIPVAG
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFG
SMKKLKEASVEEIKEAGVPMNVAEEVHKHITTFNEKAKNTEQK

Sequences:

>Translated_603_residues
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKVLKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEI
NLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVC
LYYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQVAAENMEFEKAGEFRDQINAIETTMEKQKMTM
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQA
VVPDTKIIVPQRGNKKELVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAM
VTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKERLPMPDLILIDGGKGQIDSAKDVLINELGLDIPVAG
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFG
SMKKLKEASVEEIKEAGVPMNVAEEVHKHITTFNEKAKNTEQK
>Mature_602_residues
SSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKVLKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEIN
LIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCL
YYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQVAAENMEFEKAGEFRDQINAIETTMEKQKMTMN
DFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQAV
VPDTKIIVPQRGNKKELVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMV
TFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKERLPMPDLILIDGGKGQIDSAKDVLINELGLDIPVAGL
AKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFGS
MKKLKEASVEEIKEAGVPMNVAEEVHKHITTFNEKAKNTEQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=603, Percent_Identity=38.6401326699834, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69432; Mature: 69301

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKVLKNRVRSYFSGTHDSKTQRLVQE
CCCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
IVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVK
HHCCEEEEECCCCEEEEEEEEHHCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHH
KDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASK
HCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHH
YKEMQDEIVAFLNGGYKTVKNDLMKKMQVAAENMEFEKAGEFRDQINAIETTMEKQKMTM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKAN
HHHHCCCHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
HIPPKEIYLPDDVDSEAVQAVVPDTKIIVPQRGNKKELVKLAYKNAKIALNEKFMLLERN
CCCCCEEECCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCEEEECCEEEEEECC
EERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKT
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEE
VEGPDDYATMREVIRRRYWRVLKERLPMPDLILIDGGKGQIDSAKDVLINELGLDIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCC
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSI
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LDGIPGVGPGRKKKLLKHFGSMKKLKEASVEEIKEAGVPMNVAEEVHKHITTFNEKAKNT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EQK
CCC
>Mature Secondary Structure 
SSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKVLKNRVRSYFSGTHDSKTQRLVQE
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
IVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVK
HHCCEEEEECCCCEEEEEEEEHHCCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHH
KDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASK
HCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHH
YKEMQDEIVAFLNGGYKTVKNDLMKKMQVAAENMEFEKAGEFRDQINAIETTMEKQKMTM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKAN
HHHHCCCHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
HIPPKEIYLPDDVDSEAVQAVVPDTKIIVPQRGNKKELVKLAYKNAKIALNEKFMLLERN
CCCCCEEECCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHHHCCCEEEECCEEEEEECC
EERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKT
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEE
VEGPDDYATMREVIRRRYWRVLKERLPMPDLILIDGGKGQIDSAKDVLINELGLDIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCC
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSI
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LDGIPGVGPGRKKKLLKHFGSMKKLKEASVEEIKEAGVPMNVAEEVHKHITTFNEKAKNT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EQK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]