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The map label for this gene is cobD [H]

Identifier: 116872543

GI number: 116872543

Start: 1139149

End: 1140234

Strand: Direct

Name: cobD [H]

Synonym: lwe1127

Alternate gene names: 116872543

Gene position: 1139149-1140234 (Clockwise)

Preceding gene: 116872542

Following gene: 116872544

Centisome position: 40.48

GC content: 35.73

Gene sequence:

>1086_bases
GTGAAAATAACGACGGCAATGCACGGTGGCAACTATAATGAACTAGCAAAACAACATGGACTAACCAAAGAAATGGTACT
TGATTTTAGTGCGAATATTAATCCACTAGGAGTTCCAGCTAGTTTAAAACAAACAATAACAGCCAATTTGGATAAACTGG
TAGAATATCCAGAACCAGATTATTTAGCGCTCCGTGCGCGAATTGCCTCGTTTCATCAACTCGATCTTGCGAATATTATC
CCTGGAAATGGTGCGACAGAGCTTATTTTTGGAATTGCAAAAGTAACAAAGGCGCAAAAAGTACTTTTACTTGCGCCTAC
TTTTGCAGAATATGAACGTGCTTTTTTTGATGCAGAAATTATTTATGCGGAATTAGCGAAAGAAACTAATTTTGACGCAG
CGGAAACAGTACTAGAAATAATCGAACGCGAAACGGAGCTTGAAGCCGTTTGTTTGTGTAATCCTAATAATCCGACTGGT
CAATTAATAAACCAAGAAGAAATGATAAAAATTGCAGATTTATGTGAAAAGAAAAACATATATTTAATTATTGATGAAGC
ATTTATGGACTTTATAGAAGAGAGCGAAACAATTTCGATGATTCCTTATTTGCAGCAATTTTCACATCTGTGTATTATTC
GTGCTTTTACTAAATTTTTTGCGATTCCAGGGCTTAGACTGGGTTATCTTCTGACAAAAAATGATTTGTTAGCAGAAGCC
TTGTTACAAATGCGAGAACCCTGGTCTATCAATACTTTTGCTGATATGGCTGGACAAATATTATTGGATGACAAGGATTA
TATTAAGCAAACTTATCAATGGATTTCCACAGAACGATCCTTTTTATATCAAGGTTTAAATGGATTTCCAGAACTTACGG
TGTACCAACCAAGTGTGAACTATATATTTTTCCATCTTGAAAAACCGCTTGATTTACGAAAAGAACTATTGTTAAAAGGG
ATTTTCGTCCGAAGTTGCGCTAATTATCGAGGTCTCACTGAAAATTATTACCGGGTTGCAGTGAAAACAAGAGCTGATAA
TATCCAACTTTTAACAGCGCTTGAGGTGATTCTCAGTGGAAATTAA

Upstream 100 bases:

>100_bases
GCAGTCAAAGTATGTATTATTCCAACAAATGAAGAACTAATGATTGCTCGTGATGTAGAAAAATATACAAAACAAACAAT
AAGTTAAGGAGCGATTTGAT

Downstream 100 bases:

>100_bases
AGCAACATGTCCGGCTTCATGTGGCGAATTGTTGCAAGGCTATATTGCTGGCGGAGAAAAGCTGATTTCATATCCCATTA
ATTGGTACTCTGAAGTGACT

Product: threonine-phosphate decarboxylase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKITTAMHGGNYNELAKQHGLTKEMVLDFSANINPLGVPASLKQTITANLDKLVEYPEPDYLALRARIASFHQLDLANII
PGNGATELIFGIAKVTKAQKVLLLAPTFAEYERAFFDAEIIYAELAKETNFDAAETVLEIIERETELEAVCLCNPNNPTG
QLINQEEMIKIADLCEKKNIYLIIDEAFMDFIEESETISMIPYLQQFSHLCIIRAFTKFFAIPGLRLGYLLTKNDLLAEA
LLQMREPWSINTFADMAGQILLDDKDYIKQTYQWISTERSFLYQGLNGFPELTVYQPSVNYIFFHLEKPLDLRKELLLKG
IFVRSCANYRGLTENYYRVAVKTRADNIQLLTALEVILSGN

Sequences:

>Translated_361_residues
MKITTAMHGGNYNELAKQHGLTKEMVLDFSANINPLGVPASLKQTITANLDKLVEYPEPDYLALRARIASFHQLDLANII
PGNGATELIFGIAKVTKAQKVLLLAPTFAEYERAFFDAEIIYAELAKETNFDAAETVLEIIERETELEAVCLCNPNNPTG
QLINQEEMIKIADLCEKKNIYLIIDEAFMDFIEESETISMIPYLQQFSHLCIIRAFTKFFAIPGLRLGYLLTKNDLLAEA
LLQMREPWSINTFADMAGQILLDDKDYIKQTYQWISTERSFLYQGLNGFPELTVYQPSVNYIFFHLEKPLDLRKELLLKG
IFVRSCANYRGLTENYYRVAVKTRADNIQLLTALEVILSGN
>Mature_361_residues
MKITTAMHGGNYNELAKQHGLTKEMVLDFSANINPLGVPASLKQTITANLDKLVEYPEPDYLALRARIASFHQLDLANII
PGNGATELIFGIAKVTKAQKVLLLAPTFAEYERAFFDAEIIYAELAKETNFDAAETVLEIIERETELEAVCLCNPNNPTG
QLINQEEMIKIADLCEKKNIYLIIDEAFMDFIEESETISMIPYLQQFSHLCIIRAFTKFFAIPGLRLGYLLTKNDLLAEA
LLQMREPWSINTFADMAGQILLDDKDYIKQTYQWISTERSFLYQGLNGFPELTVYQPSVNYIFFHLEKPLDLRKELLLKG
IFVRSCANYRGLTENYYRVAVKTRADNIQLLTALEVILSGN

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=336, Percent_Identity=27.6785714285714, Blast_Score=98, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6322075, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41034; Mature: 41034

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITTAMHGGNYNELAKQHGLTKEMVLDFSANINPLGVPASLKQTITANLDKLVEYPEPD
CEEEEEECCCCHHHHHHHHCCCHHHHEECCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCC
YLALRARIASFHQLDLANIIPGNGATELIFGIAKVTKAQKVLLLAPTFAEYERAFFDAEI
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHH
IYAELAKETNFDAAETVLEIIERETELEAVCLCNPNNPTGQLINQEEMIKIADLCEKKNI
HHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCE
YLIIDEAFMDFIEESETISMIPYLQQFSHLCIIRAFTKFFAIPGLRLGYLLTKNDLLAEA
EEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
LLQMREPWSINTFADMAGQILLDDKDYIKQTYQWISTERSFLYQGLNGFPELTVYQPSVN
HHHHCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
YIFFHLEKPLDLRKELLLKGIFVRSCANYRGLTENYYRVAVKTRADNIQLLTALEVILSG
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCC
N
C
>Mature Secondary Structure
MKITTAMHGGNYNELAKQHGLTKEMVLDFSANINPLGVPASLKQTITANLDKLVEYPEPD
CEEEEEECCCCHHHHHHHHCCCHHHHEECCCCCCCCCCCHHHHHHHHHCHHHHHCCCCCC
YLALRARIASFHQLDLANIIPGNGATELIFGIAKVTKAQKVLLLAPTFAEYERAFFDAEI
HHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHH
IYAELAKETNFDAAETVLEIIERETELEAVCLCNPNNPTGQLINQEEMIKIADLCEKKNI
HHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCE
YLIIDEAFMDFIEESETISMIPYLQQFSHLCIIRAFTKFFAIPGLRLGYLLTKNDLLAEA
EEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHH
LLQMREPWSINTFADMAGQILLDDKDYIKQTYQWISTERSFLYQGLNGFPELTVYQPSVN
HHHHCCCCCCCHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
YIFFHLEKPLDLRKELLLKGIFVRSCANYRGLTENYYRVAVKTRADNIQLLTALEVILSG
EEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]