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The map label for this gene is ydgF [H]

Identifier: 116872166

GI number: 116872166

Start: 769755

End: 771131

Strand: Direct

Name: ydgF [H]

Synonym: lwe0746

Alternate gene names: 116872166

Gene position: 769755-771131 (Clockwise)

Preceding gene: 116872165

Following gene: 116872167

Centisome position: 27.35

GC content: 37.18

Gene sequence:

>1377_bases
ATGGAAGAGCAAAAAGAAGAATTGCAAAGAGGACTGAAAAACAGACATATTCAGTTGATTGCGATTGGCGGAGCAATTGG
AACGGGGCTTTTTCTAGGAGCAGGTAAATCAATTCATTTAGCCGGTCCATCTATCATGTTAGTTTACTTAATTATTGGAG
CGATTTTATTTTTTGTAATGAGAGCTCTGGGTGAATTACTAATACATAACCCAACAACAGGGTCTTTCACAGAATTTGCA
GAGCAGTTTATAGGACCATGGGCAGGATTTATTACTGGTTGGACGTATTGGTTCTGTTGGATTGTTACTGGTATTGCAGA
AATCACAGCGGTTGGTATGTATGTGAAGTTTTGGGTGCCAGATTTACCACAATGGATTCCAGCTCTTGCATGCGTTTTGA
TACTATTACTCTTTAATTTAGCCACTGTTAAAGCTTTTGGCGAAATTGAATTCTGGTTTGCGATTATTAAGGTAGTTGTT
ATTATCGCTTTAATTGTCATTGGGTTTGTACTTGTATTTATTGGCTATAAACATGGAACAAGTACGGCATCATTTTCTAA
CTTAGTCGATTATGGTGGCTTTTTCCCAAATGGAATTGCTGGATTTTTATTAGCATTCCAAATGGCGACTTTTTCGTTCG
TTGGAATTGAGCTCGTTGGTGTAACAGCTGGAGAAGCGGATGACCCAGAACGAACGCTTCCAAAAGCAATTAATAATATT
CCCATTCGGATATTAATTTTCTATATTGGTGCTTTATTAGTATTGATGTCAATTTATCCATGGAGTAATATTGATCCCAA
CACGAGCCCGTTCGTAAGTGTGTTTACGATGATTGGTATTCCAGCAGCTGCAGGTATTATAAATTTTGTTGTATTAACAG
CAGCAATGTCTTCCTGTAATAGTGGGATTTTCAGTACAAGTCGGATGCTCTATACACTTTCAGCAGAAGGAAAAGCACCG
AAAAAAATGCATCACTTAAGTTCAAATGGAGTGCCTGCAACAGCTTTAATAACTTCTACGGCATGTTTACTTATCGGTGT
ATTCTTAAATTATGTTTTACCAGAACAAGTATTTATTTTAGTTACTAGCATTGCAACGATTTGCTTTATCTGGGTTTGGG
GTGTCATTTTGGTGGCTCATTTGCGTTTCCGCCATAAACATCCTGAAATTGCAGCAAAAAGTAAATTTAAAATGCCTTTA
TCACCAGTGATGAACTGGGTAAGCTTGGTTTTCTTTGCAGGCTTATTGATAATCCTTGGTTTTGCAGCAGATACACGAAT
TGCGCTTTTTGTTACGCCAGTGTGGTTCTTGATTTTAGCAATAGCGTATCAGATTTTAAAAGCATCTAATCGAAAGACAA
AAATTCGACATAATTAA

Upstream 100 bases:

>100_bases
CCTTTATAAATTGGTAAAGTAGAGAAGTAGATTAATGGATAAAGTGCTGATTTAACTCGGCGCTTTATTCTGTTTAGTTA
CTCGAAAGGGATGAATTAGG

Downstream 100 bases:

>100_bases
TTAAAAGGCAATCATTCGCTAAAGCAAGCAGTTTTAACGAATGATTGCCTTTTTTTGATACTTATAAATGCTCACGAATT
TCTTTACAAATTTAAAAAAT

Product: amino acid permease family protein

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYVLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAAKSKFKMPL
SPVMNWVSLVFFAGLLIILGFAADTRIALFVTPVWFLILAIAYQILKASNRKTKIRHN

Sequences:

>Translated_458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYVLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAAKSKFKMPL
SPVMNWVSLVFFAGLLIILGFAADTRIALFVTPVWFLILAIAYQILKASNRKTKIRHN
>Mature_458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYVLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAAKSKFKMPL
SPVMNWVSLVFFAGLLIILGFAADTRIALFVTPVWFLILAIAYQILKASNRKTKIRHN

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=341, Percent_Identity=26.099706744868, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI115648063, Length=388, Percent_Identity=28.0927835051546, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI115648022, Length=388, Percent_Identity=28.0927835051546, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=22.5882352941176, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71999149, Length=361, Percent_Identity=24.6537396121884, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI181337167, Length=345, Percent_Identity=21.1594202898551, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614005, Length=383, Percent_Identity=22.4543080939948, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=53.5087719298246, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=48.2456140350877, Blast_Score=425, Evalue=1e-120,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=44.6188340807175, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=43.7086092715232, Blast_Score=408, Evalue=1e-115,
Organism=Escherichia coli, GI1786602, Length=451, Percent_Identity=44.5676274944568, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI87081915, Length=409, Percent_Identity=42.7872860635697, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=34.2733188720174, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI1788480, Length=477, Percent_Identity=35.2201257861635, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=35.3348729792148, Blast_Score=274, Evalue=7e-75,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=25.6140350877193, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081869, Length=325, Percent_Identity=21.5384615384615, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=396, Percent_Identity=22.2222222222222, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=457, Percent_Identity=22.3194748358862, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=33.630289532294, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6324061, Length=442, Percent_Identity=33.0316742081448, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=494, Percent_Identity=30.9716599190283, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322892, Length=445, Percent_Identity=31.0112359550562, Blast_Score=190, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=30.4740406320542, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=424, Percent_Identity=32.0754716981132, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=30.1507537688442, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319608, Length=456, Percent_Identity=27.4122807017544, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=28.4037558685446, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=400, Percent_Identity=27.75, Blast_Score=162, Evalue=9e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=24.5657568238213, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=25.6857855361596, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=433, Percent_Identity=26.7898383371824, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=30.0248138957816, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=27.0471464019851, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=27.9596977329975, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=408, Percent_Identity=28.921568627451, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=25.1485148514851, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24668806, Length=430, Percent_Identity=22.7906976744186, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356285, Length=430, Percent_Identity=22.7906976744186, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24668802, Length=430, Percent_Identity=22.7906976744186, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221512776, Length=340, Percent_Identity=21.4705882352941, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666159, Length=340, Percent_Identity=21.4705882352941, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077963, Length=360, Percent_Identity=22.5, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24667468, Length=340, Percent_Identity=22.3529411764706, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366235, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI116007820, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50244; Mature: 50244

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVM
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
RALGELLIHNPTTGSFTEFAEQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVP
HHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVVIIALIVIGFVLVFIGYKHGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
STASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHCCC
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIFSTSRMLYTLSAEGKAPKKMHHLSSNGVPATALITSTACLLIGVFLNYVLPEQVFIL
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATICFIWVWGVILVAHLRFRHKHPEIAAKSKFKMPLSPVMNWVSLVFFAGLLIILG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FAADTRIALFVTPVWFLILAIAYQILKASNRKTKIRHN
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVM
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
RALGELLIHNPTTGSFTEFAEQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVP
HHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVVIIALIVIGFVLVFIGYKHGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
STASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHCCC
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIFSTSRMLYTLSAEGKAPKKMHHLSSNGVPATALITSTACLLIGVFLNYVLPEQVFIL
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATICFIWVWGVILVAHLRFRHKHPEIAAKSKFKMPLSPVMNWVSLVFFAGLLIILG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
FAADTRIALFVTPVWFLILAIAYQILKASNRKTKIRHN
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]