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The map label for this gene is tlpA [H]

Identifier: 116872112

GI number: 116872112

Start: 717693

End: 719492

Strand: Direct

Name: tlpA [H]

Synonym: lwe0692

Alternate gene names: 116872112

Gene position: 717693-719492 (Clockwise)

Preceding gene: 116872111

Following gene: 116872113

Centisome position: 25.5

GC content: 35.78

Gene sequence:

>1800_bases
GTGAATTTAATTAAAAATCGTAAATTGAAAACCAAATTAAGTATCAATATTGTTATAACGACCATTATGCTAATTGGACT
TGGCGCAACTAGTTTTTTAGGATTTCGTCATGTAGCAGAACTATCGGATAATATGGTAGATAATAATGTAGCACCAATGA
AAGAAATCGCAAAAATTCAAACAAACATGGCGCAAATCAATATCGACATCCTGACCATGTTCGATACTATTAACGGAAAA
GCAACTCTTATTAAAGATATCGATACACTTTATGCAGAAAATGACCAAGCAATCCATAACTTCAAAAAAGCCAATTTAAC
CGCAGAAGATAAAAAACAATTAGCTTATTTTGAAGAGAAATTAGCAGACATGAAATCATCCGCGTCCTCTGTAATCAGCG
ACACATCCAGTGCGCTAGATGATGCAGAATTACTCGGAGCACAAAATAGATATTACCAAAACGTTAAAACAAAATTTGAT
GATGCAACAAAACAATTAAACGTTTTAAATGAAATGAATTATAATGAAGTCGAAAAATCTTCTCAGGCCATTTCCGATTT
TGGCGTAAAAATCAGTTTAATTTTCACCGCAGTAATTATTGCCGTGCTGATTTCATTATTTGTTTTCAACGCCTATATTA
CAAAAGTTATTCTTAAAGGAATTCGTCATCTGCAAACAGCAGTACATAAAGTAGCTAGTGGAGATTTGTCCTATCGTAGC
ACTTATAATGGTAGAGATGAGTTAGGCGATATCACTAATGACCTAAACGAAATGAGCGAAAACCTACGTTTAATGATTGA
AGACGTTAAAAAAGCTTCCACTGATGTAAAATCTTCAAGTGATAACGTTATTATTAGTTCAGAAATTATTTCCGCGATGA
CAACAGAAATGGACATTGAAATGAAAATGATGGGTGAACAAATTCAAACACAAATCGGTAGCATGAAAGAAAGTACAGAT
GCCATGGATCAAATGACAGGTGGCGTTCAAAACGTTGCTGAATATGCCCTAAAAGTATCTGACTTAACAAAAGACTCCGC
AGAAAAAACGAACGATGGAATTGCAGTTATTAATAATTTAGTATCACAAATGGACCGTATCAGTGGTGTTATGCGTTCAA
GTACAGACGTAGTTTCTCAATTAGTTAACCGTGTTGGTGAAGTGGAAAAAGCACTGGATACTGTTACAAATATCGCTGAT
CAAACCAATTTACTTGCCTTAAACGCTGCAATCGAATCTGCTCGAGCTGGCGAACATGGTCGTGGCTTTGCTGTCGTAGC
TGAAGAAGTTCGTAAGTTAGCAGAACAATCTCGCCTTGCTGTAGTAGATATTAATACTGTCTTGAAAAAAATTCAAACAG
AATCAAAAACAACTATCGAAGTAATGAATACAGGTCTATCTGAATCGGAAGCAGGCCAAAAAATCATTTCTGAAACAGAA
GCAACATTTACAGATTTACTCAACCGTGTCAACGATATTTCTGCCCAAATGCAAAACGTCTCTCAAGAAACTGAAGAGAT
GGCAGCAGGAATTGAGGAAGTAAATACATCTATTAGCGATGTAACAGAAATCTCCAATCAAATTGGTGAAAAATCTACAG
CTGCACTTGAATTTGCCGAAGTAAATAAAATGAAAGTGGACGAACTAGTTGTTATCTCAGAAGAAATGCAAAAAATTTCT
GGTTCATTAGAAGGGTATATCGCCAACTTCAATACCGAAGTGAGCGAAGAAGTGGTCGAAGTACAAGAAGAAACAGAAAC
AAAAGATCCCGGAGAGCCAGTCCTAGCAGAAAATGTCTAG

Upstream 100 bases:

>100_bases
TGTTTTTTTATTAAAACTAATTATTTTACAATAAAATATGGAGTTTTTTTAAAAAATATGAGATAATAAACAAGAATTAG
AGAATAGGAGTGTGGAATGG

Downstream 100 bases:

>100_bases
GTAGCATGTAGAAATGCGAATTTGGATAAAATCGTTGCTTGTTATTACAGCGTGTATATTTAGTTTGACCCTTCTAAATA
CGAAATATACCTTTTATGCA

Product: methyl-accepting chemotaxis protein, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVAELSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
ATLIKDIDTLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYNEVEKSSQAISDFGVKISLIFTAVIIAVLISLFVFNAYITKVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEVVEVQEETETKDPGEPVLAENV

Sequences:

>Translated_599_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVAELSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
ATLIKDIDTLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYNEVEKSSQAISDFGVKISLIFTAVIIAVLISLFVFNAYITKVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEVVEVQEETETKDPGEPVLAENV
>Mature_599_residues
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVAELSDNMVDNNVAPMKEIAKIQTNMAQINIDILTMFDTINGK
ATLIKDIDTLYAENDQAIHNFKKANLTAEDKKQLAYFEEKLADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFD
DATKQLNVLNEMNYNEVEKSSQAISDFGVKISLIFTAVIIAVLISLFVFNAYITKVILKGIRHLQTAVHKVASGDLSYRS
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIEMKMMGEQIQTQIGSMKESTD
AMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNLVSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIAD
QTNLLALNAAIESARAGEHGRGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAEVNKMKVDELVVISEEMQKIS
GSLEGYIANFNTEVSEEVVEVQEETETKDPGEPVLAENV

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788194, Length=597, Percent_Identity=24.7906197654941, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1787690, Length=352, Percent_Identity=26.7045454545455, Blast_Score=129, Evalue=7e-31,
Organism=Escherichia coli, GI2367378, Length=348, Percent_Identity=29.5977011494253, Blast_Score=122, Evalue=9e-29,
Organism=Escherichia coli, GI1788195, Length=315, Percent_Identity=26.031746031746, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789453, Length=343, Percent_Identity=26.530612244898, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 65709; Mature: 65709

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVAELSDNMVDNNVAPMKEIAKIQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TNMAQINIDILTMFDTINGKATLIKDIDTLYAENDQAIHNFKKANLTAEDKKQLAYFEEK
HHHHHEEEEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
LADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFDDATKQLNVLNEMNYNEVEKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SQAISDFGVKISLIFTAVIIAVLISLFVFNAYITKVILKGIRHLQTAVHKVASGDLSYRS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKMMGEQIQTQIGSMKESTDAMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHH
VSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIADQTNLLALNAAIESARAGEHG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
RGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHH
VNKMKVDELVVISEEMQKISGSLEGYIANFNTEVSEEVVEVQEETETKDPGEPVLAENV
HCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNLIKNRKLKTKLSINIVITTIMLIGLGATSFLGFRHVAELSDNMVDNNVAPMKEIAKIQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TNMAQINIDILTMFDTINGKATLIKDIDTLYAENDQAIHNFKKANLTAEDKKQLAYFEEK
HHHHHEEEEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
LADMKSSASSVISDTSSALDDAELLGAQNRYYQNVKTKFDDATKQLNVLNEMNYNEVEKS
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SQAISDFGVKISLIFTAVIIAVLISLFVFNAYITKVILKGIRHLQTAVHKVASGDLSYRS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TYNGRDELGDITNDLNEMSENLRLMIEDVKKASTDVKSSSDNVIISSEIISAMTTEMDIE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHH
MKMMGEQIQTQIGSMKESTDAMDQMTGGVQNVAEYALKVSDLTKDSAEKTNDGIAVINNL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHH
VSQMDRISGVMRSSTDVVSQLVNRVGEVEKALDTVTNIADQTNLLALNAAIESARAGEHG
HHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCC
RGFAVVAEEVRKLAEQSRLAVVDINTVLKKIQTESKTTIEVMNTGLSESEAGQKIISETE
CCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ATFTDLLNRVNDISAQMQNVSQETEEMAAGIEEVNTSISDVTEISNQIGEKSTAALEFAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHHH
VNKMKVDELVVISEEMQKISGSLEGYIANFNTEVSEEVVEVQEETETKDPGEPVLAENV
HCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]