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The map label for this gene is isdG [H]

Identifier: 116871872

GI number: 116871872

Start: 487994

End: 488359

Strand: Direct

Name: isdG [H]

Synonym: lwe0452

Alternate gene names: 116871872

Gene position: 487994-488359 (Clockwise)

Preceding gene: 116871871

Following gene: 116871873

Centisome position: 17.34

GC content: 40.44

Gene sequence:

>366_bases
ATGATTATTGTAACTAATACGATTAAGGTAGAAAAAGGCGCAGCAGAGCACGTGATTCGTCAGTTCACAGGCGCAAATGG
CGACGGACATCCAACTAAAGATATCGCAGAAGTAGAAGGATTTCTGGGCTTCGAACTATGGCACAGTAAACCAGAAGACA
AAGATTATGAAGAAGTAGTCGTTACAAGTAAATGGGAAAGCGAAGAAGCGCAACGCAATTGGGTAAAAAGTGATTCCTTC
AAAAAAGCGCATGGTAGAACAAAAGACACAAGAGAACAAAGAGAAGATCGCAAAGGCATCGTAGGAAATGAAATTGCTCG
TTTCGAAGTGGTTCATGTGCAAAATCCTGTGACTATTGAAAAATAA

Upstream 100 bases:

>100_bases
AATCCCATTTTCCAACATTGACAATGAGAATCATTATCAATATAATGGAAGGAACAAGCCTATTATACATACAATACAAT
TATCCAAGGGGGATTTAAGA

Downstream 100 bases:

>100_bases
GAAGTGAGTGAACAAGCCGTTTCGAGGTAGATGGCTTGTTTTTTTGTGGCGCTTGAATTTTCAAATAATTATTGAATTTT
TATATCTTATGCGGTATATT

Product: heme-degrading monooxygenase IsdG

Products: NA

Alternate protein names: Heme oxygenase; Iron-regulated surface determinant isdG; Iron-responsive surface determinant isdG [H]

Number of amino acids: Translated: 121; Mature: 121

Protein sequence:

>121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIEK

Sequences:

>Translated_121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIEK
>Mature_121_residues
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVVVTSKWESEEAQRNWVKSDSF
KKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIEK

Specific function: Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subseque

COG id: COG2329

COG function: function code R; Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase isdG subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007138
- InterPro:   IPR011008 [H]

Pfam domain/function: PF03992 ABM [H]

EC number: =1.14.99.3 [H]

Molecular weight: Translated: 13846; Mature: 13846

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVV
CEEECCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEE
VTSKWESEEAQRNWVKSDSFKKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIE
EECCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCCEEEC
K
C
>Mature Secondary Structure
MIIVTNTIKVEKGAAEHVIRQFTGANGDGHPTKDIAEVEGFLGFELWHSKPEDKDYEEVV
CEEECCEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHEE
VTSKWESEEAQRNWVKSDSFKKAHGRTKDTREQREDRKGIVGNEIARFEVVHVQNPVTIE
EECCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHCCCCCCCCEEEEEEEECCCEEEC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]