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The map label for this gene is yyaH [H]

Identifier: 116871790

GI number: 116871790

Start: 386612

End: 386992

Strand: Direct

Name: yyaH [H]

Synonym: lwe0370

Alternate gene names: 116871790

Gene position: 386612-386992 (Clockwise)

Preceding gene: 116871789

Following gene: 116871791

Centisome position: 13.74

GC content: 33.33

Gene sequence:

>381_bases
ATGAAAATTGAACATATTGCTTTATGGACGACGGATTTGGAAAAAATGAAAGACTTTTATGTAAAATATTTTGGTGTAAC
AGCCAATGACTTATATGAAAACAAGACAAAAGGTTTTACATCTTATTTTTTATCATTTGAAAATGGAGCCAGACTTGAGA
TTATGAGTCGGACAGATGTAACTGGGAAAAATCTTGGAGAAAATTTAGGATGGGCGCATATTGCTATTTCAACTGGTACA
AAAGAAATGGTTGACGAACTAACAGAAAAACTAAGAAAAGATGGTTTTAAAGTTGCTGGAGAAACGAGAACAACAGGGGA
TGGATATTACGAAAGTGTTGTGCTAGATCCAGAAGGAAATCGTATCGAAATAACTTGTTAA

Upstream 100 bases:

>100_bases
GGTGGTCACATGGTTTATCACTTTGCCACTAGCTGGACTTTTGGCAGCAGTGGTATACTGGATATCAGCAGCTATTTTCT
TATAAGAAGGAGGATTTTTA

Downstream 100 bases:

>100_bases
TATTGATTTGTCAGCAACTAAATAATCATGTAAGATACAGGTAATACATATTAATAATGAGGTGAAGTTTGTGGATATCG
TAACGAATAAAATCGTCGTA

Product: glyoxalase family protein

Products: glutathione; methylglyoxal

Alternate protein names: ORFF [H]

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MKIEHIALWTTDLEKMKDFYVKYFGVTANDLYENKTKGFTSYFLSFENGARLEIMSRTDVTGKNLGENLGWAHIAISTGT
KEMVDELTEKLRKDGFKVAGETRTTGDGYYESVVLDPEGNRIEITC

Sequences:

>Translated_126_residues
MKIEHIALWTTDLEKMKDFYVKYFGVTANDLYENKTKGFTSYFLSFENGARLEIMSRTDVTGKNLGENLGWAHIAISTGT
KEMVDELTEKLRKDGFKVAGETRTTGDGYYESVVLDPEGNRIEITC
>Mature_126_residues
MKIEHIALWTTDLEKMKDFYVKYFGVTANDLYENKTKGFTSYFLSFENGARLEIMSRTDVTGKNLGENLGWAHIAISTGT
KEMVDELTEKLRKDGFKVAGETRTTGDGYYESVVLDPEGNRIEITC

Specific function: Unknown

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 4.4.1.5

Molecular weight: Translated: 14306; Mature: 14306

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEHIALWTTDLEKMKDFYVKYFGVTANDLYENKTKGFTSYFLSFENGARLEIMSRTDV
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCC
TGKNLGENLGWAHIAISTGTKEMVDELTEKLRKDGFKVAGETRTTGDGYYESVVLDPEGN
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCCCC
RIEITC
EEEEEC
>Mature Secondary Structure
MKIEHIALWTTDLEKMKDFYVKYFGVTANDLYENKTKGFTSYFLSFENGARLEIMSRTDV
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCC
TGKNLGENLGWAHIAISTGTKEMVDELTEKLRKDGFKVAGETRTTGDGYYESVVLDPEGN
CCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCEECCCCCCCCCCEEEEEEECCCCC
RIEITC
EEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-S-lactoylglutathione

Specific reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 8011666; 9384377 [H]