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The map label for this gene is manP [H]

Identifier: 116871782

GI number: 116871782

Start: 378007

End: 378465

Strand: Direct

Name: manP [H]

Synonym: lwe0362

Alternate gene names: 116871782

Gene position: 378007-378465 (Clockwise)

Preceding gene: 116871781

Following gene: 116871783

Centisome position: 13.43

GC content: 37.47

Gene sequence:

>459_bases
ATGATAGTATCAGAAGAACAATTATTTTTAAATCAGCATCTAAGCACAAAAGCAGAAGTGCTAGCTTTTATTGCAGACAA
GGCAGCTGAAATTGGTATCACAACTAATTCAGCGCAAGTAGAGCGAGATTTATGGGCCCGCGAAAAAGAGTACGCAACAG
CAGTGCAACAATTAATCGCAATTCCACATGCGAAAACAGAGGCGATATCGGAAGCAAAACTACTTTTTATTCGTTTGGTT
GACCCGATTGATTGGGAGTCAAATGAAGGTTTTCAAGCACAAGCCATTTTTGCGATATTAGTTCCAGCAAGTGAGGCAAG
TCAGCAACATCTGAAAATTTTATCAAGTGTGGCTGTGAATTTACTAGAAGAAGCGTTTCAAGAACAAATTTTAACAATTC
AAACGGAACACGAACTGATGAATTACTTAAAAGATAATTTGGAAGGAGAATTGATATGA

Upstream 100 bases:

>100_bases
TTTTTCCACTTTAACTGGAAATTCCTTATGTTCAAAAAAGTAATCGGTTTCATTAGAATGTAATTGTAAGCAAGGCATTG
AAAAAATACGGGGTGACGAA

Downstream 100 bases:

>100_bases
AAGTTGTAGGAGTTACGTCATGTATCGCAGGACTCGCGCACACACCAATGGCAGCAAAAGCATTAGAAAAAGCGGGAGTG
AAATTAGGACACGATGTCAA

Product: PTS system, fructose-specific, IIA component

Products: NA

Alternate protein names: EIIBCA-Man; EII-Man; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific EIIB component; Mannose permease IIC component; PTS system mannose-specific EIIC component; Mannose-specific phosphotransferase enzyme IIA component; PTS system mannose-specific EIIA component [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MIVSEEQLFLNQHLSTKAEVLAFIADKAAEIGITTNSAQVERDLWAREKEYATAVQQLIAIPHAKTEAISEAKLLFIRLV
DPIDWESNEGFQAQAIFAILVPASEASQQHLKILSSVAVNLLEEAFQEQILTIQTEHELMNYLKDNLEGELI

Sequences:

>Translated_152_residues
MIVSEEQLFLNQHLSTKAEVLAFIADKAAEIGITTNSAQVERDLWAREKEYATAVQQLIAIPHAKTEAISEAKLLFIRLV
DPIDWESNEGFQAQAIFAILVPASEASQQHLKILSSVAVNLLEEAFQEQILTIQTEHELMNYLKDNLEGELI
>Mature_152_residues
MIVSEEQLFLNQHLSTKAEVLAFIADKAAEIGITTNSAQVERDLWAREKEYATAVQQLIAIPHAKTEAISEAKLLFIRLV
DPIDWESNEGFQAQAIFAILVPASEASQQHLKILSSVAVNLLEEAFQEQILTIQTEHELMNYLKDNLEGELI

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG1762

COG function: function code GT; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1786951, Length=145, Percent_Identity=26.2068965517241, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI1788726, Length=142, Percent_Identity=27.4647887323944, Blast_Score=71, Evalue=4e-14,
Organism=Escherichia coli, GI48994992, Length=147, Percent_Identity=29.2517006802721, Blast_Score=70, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004715
- InterPro:   IPR003353
- InterPro:   IPR006327 [H]

Pfam domain/function: PF00359 PTS_EIIA_2; PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 17044; Mature: 17044

Theoretical pI: Translated: 4.22; Mature: 4.22

Prosite motif: PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSEEQLFLNQHLSTKAEVLAFIADKAAEIGITTNSAQVERDLWAREKEYATAVQQLIA
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPHAKTEAISEAKLLFIRLVDPIDWESNEGFQAQAIFAILVPASEASQQHLKILSSVAVN
CCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHHHH
LLEEAFQEQILTIQTEHELMNYLKDNLEGELI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIVSEEQLFLNQHLSTKAEVLAFIADKAAEIGITTNSAQVERDLWAREKEYATAVQQLIA
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IPHAKTEAISEAKLLFIRLVDPIDWESNEGFQAQAIFAILVPASEASQQHLKILSSVAVN
CCCCHHHHHHHHHHHEEEECCCCCCCCCCCCHHEEEEEEEECCCHHHHHHHHHHHHHHHH
LLEEAFQEQILTIQTEHELMNYLKDNLEGELI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]