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The map label for this gene is ung [H]

Identifier: 116871758

GI number: 116871758

Start: 360333

End: 360998

Strand: Direct

Name: ung [H]

Synonym: lwe0338

Alternate gene names: 116871758

Gene position: 360333-360998 (Clockwise)

Preceding gene: 116871756

Following gene: 116871759

Centisome position: 12.8

GC content: 36.64

Gene sequence:

>666_bases
ATGATGAAAAATTGGGATGAATTTTTAAAAGAAGAAGCAAAGCAGCCTTATTTTATTAAATTAATGGAAGAAGTCGCGGA
AGCTAGAACAAAAGGAAATGTGTATCCAACAGAGGAAGACATGTTTTCGTGTTTCCGATTATGTCCATATGACAAAGTTA
AAGTCGTTATTCTTGGTCAAGATCCATACCACGGTGCAGGACAGGCACATGGGTTAAGTTTTTCCGTTCAAAAAGGTGTG
AAAATACCACCAAGCCTTCGAAATATTTATAAAGAATTACAGACTGATTTGGAAATAGAACCAGCTGATCATGGCTATCT
TGCTAAATGGGCGGAACAAGGTGTGCTTTTGATGAACACAAGTTGGAGTGTTGAAGAAGGCAAAGCTGGTAGTCATAAAA
AATTAGGCTGGGCAACATTTACGAATCATGTGTTGGAAGAATTAAATAATTATGATAAACCATTAGTATTTATTTTATGG
GGAAATCACGCGATAAAAGCGACGAGCGGTATTGATAATCCAAAACATCTACTCATTAAAGGTGTTCACCCATCTCCATT
AGCTGCAAGAGGTGGCTTTTTCGGCAGTAAACCATTTTCCGAGACAAATGCGTTCTTAAAACAAAATGGGAGAACTCCAA
TTGATTGGGATTTAAATAGTAAATAA

Upstream 100 bases:

>100_bases
CCATGTGAAACGCAAATTTTTCATACTTTTGACAGTGGCTTAGATAGAACAGTATAATTAGAGGGCAGAATTATTTATTA
CTAAGATGGGAGAGAATGAA

Downstream 100 bases:

>100_bases
TTTTACTTTGAACATATTTTCTTTCTATTACAATTTTTAAATTAAAAGTGAAAAAATTTACAAAATTATTAATAAAAGCT
TTTTACATAAGGTTTCATTC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG 1 [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MMKNWDEFLKEEAKQPYFIKLMEEVAEARTKGNVYPTEEDMFSCFRLCPYDKVKVVILGQDPYHGAGQAHGLSFSVQKGV
KIPPSLRNIYKELQTDLEIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTNHVLEELNNYDKPLVFILW
GNHAIKATSGIDNPKHLLIKGVHPSPLAARGGFFGSKPFSETNAFLKQNGRTPIDWDLNSK

Sequences:

>Translated_221_residues
MMKNWDEFLKEEAKQPYFIKLMEEVAEARTKGNVYPTEEDMFSCFRLCPYDKVKVVILGQDPYHGAGQAHGLSFSVQKGV
KIPPSLRNIYKELQTDLEIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTNHVLEELNNYDKPLVFILW
GNHAIKATSGIDNPKHLLIKGVHPSPLAARGGFFGSKPFSETNAFLKQNGRTPIDWDLNSK
>Mature_221_residues
MMKNWDEFLKEEAKQPYFIKLMEEVAEARTKGNVYPTEEDMFSCFRLCPYDKVKVVILGQDPYHGAGQAHGLSFSVQKGV
KIPPSLRNIYKELQTDLEIEPADHGYLAKWAEQGVLLMNTSWSVEEGKAGSHKKLGWATFTNHVLEELNNYDKPLVFILW
GNHAIKATSGIDNPKHLLIKGVHPSPLAARGGFFGSKPFSETNAFLKQNGRTPIDWDLNSK

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=50.9259259259259, Blast_Score=215, Evalue=2e-56,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=50.9259259259259, Blast_Score=215, Evalue=3e-56,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=50.6976744186047, Blast_Score=227, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=47.926267281106, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6323620, Length=232, Percent_Identity=45.2586206896552, Blast_Score=187, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24949; Mature: 24949

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKNWDEFLKEEAKQPYFIKLMEEVAEARTKGNVYPTEEDMFSCFRLCPYDKVKVVILGQ
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGAGQAHGLSFSVQKGVKIPPSLRNIYKELQTDLEIEPADHGYLAKWAEQGVLLMNT
CCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SWSVEEGKAGSHKKLGWATFTNHVLEELNNYDKPLVFILWGNHAIKATSGIDNPKHLLIK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCCCEEEEE
GVHPSPLAARGGFFGSKPFSETNAFLKQNGRTPIDWDLNSK
CCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MMKNWDEFLKEEAKQPYFIKLMEEVAEARTKGNVYPTEEDMFSCFRLCPYDKVKVVILGQ
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGAGQAHGLSFSVQKGVKIPPSLRNIYKELQTDLEIEPADHGYLAKWAEQGVLLMNT
CCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCEEEEEC
SWSVEEGKAGSHKKLGWATFTNHVLEELNNYDKPLVFILWGNHAIKATSGIDNPKHLLIK
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCCCCCEEEEE
GVHPSPLAARGGFFGSKPFSETNAFLKQNGRTPIDWDLNSK
CCCCCCCHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]