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The map label for this gene is frdC [H]

Identifier: 116871732

GI number: 116871732

Start: 336680

End: 338206

Strand: Direct

Name: frdC [H]

Synonym: lwe0312

Alternate gene names: 116871732

Gene position: 336680-338206 (Clockwise)

Preceding gene: 116871730

Following gene: 116871733

Centisome position: 11.96

GC content: 37.66

Gene sequence:

>1527_bases
ATGAAAAAAAGGTTAGCTACAATGTTCATCATGCTACTATCACTTGTATTAATTTTTGCGGGCTGTGGAAGTAATGACAC
AAGTAAAAGTGATGCAGCGAAAACAAAAGACAAAGAAAAAGACAAAACAGAAGTAACATCAGGAGCGTCAAAAACAAGCT
ACACAGATCCATCTAAATTAAAAGATACATATGATATCGTTATTATCGGTGCAGGTGGCGCGGGAATGTCAGCAGCATTA
GAAGCAAAAGCGAAAGGATTGAACCCAGTAATACTTGAAAAAATGCCGCTAGCAGGTGGAAACACGATGAAAGCATCTTC
GGGTATGAACGCATCAGAAACTAAATTCCAAAAAGAACAAGGAATTAATGATAGCAATGACAAGTTTTATGAAGAAACAT
TAAAAGGTGGTCACGGAACAAACGATAAAGAAATGCTTCGTTTCTTCGTAGACAATTCCGCAAGCGCAATTGACTGGTTG
GATTCGATGGATATTAAATTAAACAACCTAACTATTACAGGCGGAATGAGTGAAAAACGTACACATCGTCCTGAAGATGG
CTCAGCAGTCGGTAAATACTTAGTAGACGGTTTACTAAAAAATGTACAAGAAGAAAAAATACCAGTATTCGTTAATGCAG
ATGTAAAAGAAATTACCCAAAAAGACGGAAAAGTAACAGGTGTTAAAGTAAAATTAAACAACAAAGATGAAAAAACAATT
AGTTCAGATGCTGTAGTTGTAACAACTGGCGGCTACGGAGCTAATAAAGATATGATTGAAAAAGAACGTCCAGATTTAAA
AGGATATGTAACAACCAACCAAGAAGGAAGTACTGGTGACGGTATTAAAATGATCGAAAAACTTGGTGGAACAACTGTCG
ATATGGACCAAATACAAGTGCACCCAACTGTTCAACAAGAGAAATCTTACCTTATTGGTGAAGCTGTCCGAGGCGAAGGT
GCAATTTTAGTTTCTCAAGATGGTAAACGTTTTGGAAATGAATTAGACACGCGAGATAACGTTACGGCTTCCATCAACAA
ATTACCAGAAAAATCCGCATACCTAGTTTTTGATGCAGGTGTAAAAGATCGTGTCAAAGCTATCGCGCAATATGACGAAA
TGGGCTTTGTGGAAGAAGGCAAAACTATTGATGAATTAGCTAGCAAAATCAATGTTCCAAAAGAAGAACTAACGAAAACA
ATAGATACTTGGAATACAAGCGTGAAAAACAAAAAAGATGAAGCATATGGTAGAACAACAGCCATGGATAATGATTTATC
TAAAGCGCCATATTACGCAATCAAAATTGGTCCAGGAATTCATTACACAATGGGCGGCGTAAAAATCAATACAAATACAG
AAGTCTTGGATAAGGACGGAAAACCAATCACAGGCCTATTTGCTGCGGGAGAAGTAACTGGTGGCTTGCACGGGGAAAAT
CGTATTGGTGGGAACTCTGTCGCTGAAATCATTATTTTCGGACGTCAAGCTGGCGATAAATCAGCTGAATTTGTAAAAGC
GCAATAA

Upstream 100 bases:

>100_bases
GACGCCCTATAAAGATACCGGAATTAGTGCTATAATATGTTAATATAATCACAAACTTTTGGCTGGAAGAAAAAATTTCA
AAAAAAGTGGAGGTACACAA

Downstream 100 bases:

>100_bases
CACTTTCTTAACCATTAGTAATGTGATTAATAAAAACTTGCTAAGACGCTTATGCTAAACGTTTTAGTAAGTTTTTTTAT
TGGCTAAATAGAGCGCTAGT

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: Fe(3+)-induced flavocytochrome C3; Ifc3; Iron(III)-induced flavocytochrome C3 [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKKRLATMFIMLLSLVLIFAGCGSNDTSKSDAAKTKDKEKDKTEVTSGASKTSYTDPSKLKDTYDIVIIGAGGAGMSAAL
EAKAKGLNPVILEKMPLAGGNTMKASSGMNASETKFQKEQGINDSNDKFYEETLKGGHGTNDKEMLRFFVDNSASAIDWL
DSMDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEEKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTI
SSDAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQEKSYLIGEAVRGEG
AILVSQDGKRFGNELDTRDNVTASINKLPEKSAYLVFDAGVKDRVKAIAQYDEMGFVEEGKTIDELASKINVPKEELTKT
IDTWNTSVKNKKDEAYGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGEN
RIGGNSVAEIIIFGRQAGDKSAEFVKAQ

Sequences:

>Translated_508_residues
MKKRLATMFIMLLSLVLIFAGCGSNDTSKSDAAKTKDKEKDKTEVTSGASKTSYTDPSKLKDTYDIVIIGAGGAGMSAAL
EAKAKGLNPVILEKMPLAGGNTMKASSGMNASETKFQKEQGINDSNDKFYEETLKGGHGTNDKEMLRFFVDNSASAIDWL
DSMDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEEKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTI
SSDAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQEKSYLIGEAVRGEG
AILVSQDGKRFGNELDTRDNVTASINKLPEKSAYLVFDAGVKDRVKAIAQYDEMGFVEEGKTIDELASKINVPKEELTKT
IDTWNTSVKNKKDEAYGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGEN
RIGGNSVAEIIIFGRQAGDKSAEFVKAQ
>Mature_508_residues
MKKRLATMFIMLLSLVLIFAGCGSNDTSKSDAAKTKDKEKDKTEVTSGASKTSYTDPSKLKDTYDIVIIGAGGAGMSAAL
EAKAKGLNPVILEKMPLAGGNTMKASSGMNASETKFQKEQGINDSNDKFYEETLKGGHGTNDKEMLRFFVDNSASAIDWL
DSMDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEEKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTI
SSDAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQEKSYLIGEAVRGEG
AILVSQDGKRFGNELDTRDNVTASINKLPEKSAYLVFDAGVKDRVKAIAQYDEMGFVEEGKTIDELASKINVPKEELTKT
IDTWNTSVKNKKDEAYGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGEN
RIGGNSVAEIIIFGRQAGDKSAEFVKAQ

Specific function: Catalyzes unidirectional fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=438, Percent_Identity=23.972602739726, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI1788928, Length=463, Percent_Identity=28.5097192224622, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790597, Length=400, Percent_Identity=27.75, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786942, Length=485, Percent_Identity=25.1546391752577, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71986328, Length=464, Percent_Identity=33.6206896551724, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI17505833, Length=438, Percent_Identity=24.6575342465753, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17550100, Length=436, Percent_Identity=24.7706422018349, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320788, Length=463, Percent_Identity=36.2850971922246, Blast_Score=253, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6322511, Length=488, Percent_Identity=34.0163934426229, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322701, Length=472, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322416, Length=499, Percent_Identity=24.8496993987976, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17137288, Length=497, Percent_Identity=25.7545271629779, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24655642, Length=497, Percent_Identity=25.7545271629779, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24655647, Length=497, Percent_Identity=25.7545271629779, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 54806; Mature: 54806

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLATMFIMLLSLVLIFAGCGSNDTSKSDAAKTKDKEKDKTEVTSGASKTSYTDPSKL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHC
KDTYDIVIIGAGGAGMSAALEAKAKGLNPVILEKMPLAGGNTMKASSGMNASETKFQKEQ
CCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCEECCCCCCHHHHHHHHHH
GINDSNDKFYEETLKGGHGTNDKEMLRFFVDNSASAIDWLDSMDIKLNNLTITGGMSEKR
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEECCCCHHH
THRPEDGSAVGKYLVDGLLKNVQEEKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEEECCCCCCEE
SSDAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQV
CCCEEEEEECCCCCCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEHHHEEE
HPTVQQEKSYLIGEAVRGEGAILVSQDGKRFGNELDTRDNVTASINKLPEKSAYLVFDAG
CCCHHHHHHHHHHHEECCCCEEEECCCCHHHCCCCCCCCCCHHHHHCCCCCCEEEEEECC
VKDRVKAIAQYDEMGFVEEGKTIDELASKINVPKEELTKTIDTWNTSVKNKKDEAYGRTT
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCC
AMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGEN
CCCCCCCCCCEEEEEECCCEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCC
RIGGNSVAEIIIFGRQAGDKSAEFVKAQ
CCCCCCEEEEEEEECCCCCCCCCCEECC
>Mature Secondary Structure
MKKRLATMFIMLLSLVLIFAGCGSNDTSKSDAAKTKDKEKDKTEVTSGASKTSYTDPSKL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCHHHC
KDTYDIVIIGAGGAGMSAALEAKAKGLNPVILEKMPLAGGNTMKASSGMNASETKFQKEQ
CCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCCCCEECCCCCCHHHHHHHHHH
GINDSNDKFYEETLKGGHGTNDKEMLRFFVDNSASAIDWLDSMDIKLNNLTITGGMSEKR
CCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEECCCCHHH
THRPEDGSAVGKYLVDGLLKNVQEEKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEEECCCCCCEE
SSDAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQV
CCCEEEEEECCCCCCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEHHHEEE
HPTVQQEKSYLIGEAVRGEGAILVSQDGKRFGNELDTRDNVTASINKLPEKSAYLVFDAG
CCCHHHHHHHHHHHEECCCCEEEECCCCHHHCCCCCCCCCCHHHHHCCCCCCEEEEEECC
VKDRVKAIAQYDEMGFVEEGKTIDELASKINVPKEELTKTIDTWNTSVKNKKDEAYGRTT
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCC
AMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGEN
CCCCCCCCCCEEEEEECCCEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCC
RIGGNSVAEIIIFGRQAGDKSAEFVKAQ
CCCCCCEEEEEEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10455032; 10581549 [H]