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The map label for this gene is yyxA [H]

Identifier: 116871686

GI number: 116871686

Start: 288298

End: 289800

Strand: Direct

Name: yyxA [H]

Synonym: lwe0266

Alternate gene names: 116871686

Gene position: 288298-289800 (Clockwise)

Preceding gene: 116871685

Following gene: 116871687

Centisome position: 10.24

GC content: 38.79

Gene sequence:

>1503_bases
ATGGACGAGAAAGAAAAAGATTTAAATGAAAACAGCGAGAATGAGAGCACGCCAAAAAGAGAGGTCGAGGAAACTTTACA
TACCCCTGAGAGCTCGCAACCTGTCCAAGAATCTCCTATAGTAGAAGGCGTGACTCCAGAAGGAGAGAAATTTGCCGGAG
CAACGGAGGAAGCTGCTGAGGCAAGTTCTACTAATGCATTTTTTGAAGAAGCAAGTAACAAAGAACCAGAGGCAACAAGA
CCAGCTCCAGGACCAAGACGCACGGGTGTAACTGGTGGCGGAGCAATTCCTCCAAATAGAGTGAATAATGGCGGAAGTGG
TAACGGGAACGGAGAACCACCGAAGCGAGGCAAACACTTTATTGGCTACTTTTTAACTGCACTTATTGGTGTTATTATCG
GCGGGCTAATCATTTTCTTTGTAGCATGGGATAGTGGTGATAACGCTGATACAACTACTAACACAAATAATAAAGCTAGC
AAAGTAGAAAAAGTTTCTGTAAATACAACATCAGATGTAACTAAAGCAGTAAATAAAGTACAAGATGCGGTAGTCAGTGT
ACTAAATTACCAATCATCTTCTTCACTTGATGGCTCCACTGGTTCTGAACAAGAAGCATCATCAGGATCCGGTGTTATTT
ACAAAAAAGCTAATGGAAAAGCATATATAGTAACAAATAATCACGTTGTTGCCGATGCAAATAAATTAGAAGTCACTTTT
TCAAGTGGTAAAAAATCAGAAGCGAAATTACTTGGAACAGACGAATGGAACGATTTAGCTGTTCTAGAAATTGATGATAA
GAATGTCAGCACCGTTGCTACATTTGGCGATTCTGATGCATTAAAACTTGGTGAACCAGCAATTGCAATTGGTAGCCCAC
TTGGAACTGAATTTTCCGGTTCTGTAACACAAGGTATTATTTCCGGTTTAAACCGTGCAGTCCCAGTTGATACAAATGGC
GACGGAACAGAAGACTGGGAAGCTGATGTTATCCAAACAGACGCAGCAATCAACCCAGGTAATAGTGGTGGAGCTTTAAT
TAATATTGAAGGCCAAGTAATTGGTATTAACTCAATGAAAATTTCAATGGAAAATGTAGAGGGTATTAGCTTTGCAATTC
CAAGTAATACCGTAGAACCAATCATTGAACAACTAGAAACTAAGGGTGAAGTTGAACGTCCATCTCTAGGTGTTTCCTTA
CGTGACGTTGACACAATTCCTGAAACACAACAAAAAAATATCTTGAAATTACCAGATAGTGTAGATTACGGCGCAATGGT
ACAACAAGTAGTATCAGGTTCTGCTGCAGCTAAAGCAGGATTAAAACAATATGATGTGATTGTTGAACTAAATGGTGAAA
AAGTAACGAATTCTATGACATTACGCAAAATTTTATATGGTAATGATGTGAAAATTGGCGATAAAGTCAAAGTGAAATAC
TATCGTGATGGGAAAGAAAAAACGACAGATATTAAATTAGAAGCAGCAAAAATAACTACATGA

Upstream 100 bases:

>100_bases
TAAGTTTCACCATTTTTTTAAAGCTTTTTCATCGTTTTTTCATATTTAAAGTTTACTATGGAAGTATATAAATGCGAATT
TTGCAGAGAGGAAGGAAGAC

Downstream 100 bases:

>100_bases
TAATGAAAAGTCATTCTCTTATAAAAAGAGAGTGACTTTTTTTCTGTGGAAAACTTGTGGATATTAATTTTTTTCGGATA
TAGATATGGTAGAGAACAGG

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MDEKEKDLNENSENESTPKREVEETLHTPESSQPVQESPIVEGVTPEGEKFAGATEEAAEASSTNAFFEEASNKEPEATR
PAPGPRRTGVTGGGAIPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDSGDNADTTTNTNNKAS
KVEKVSVNTTSDVTKAVNKVQDAVVSVLNYQSSSSLDGSTGSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
SSGKKSEAKLLGTDEWNDLAVLEIDDKNVSTVATFGDSDALKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAAAKAGLKQYDVIVELNGEKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKTTDIKLEAAKITT

Sequences:

>Translated_500_residues
MDEKEKDLNENSENESTPKREVEETLHTPESSQPVQESPIVEGVTPEGEKFAGATEEAAEASSTNAFFEEASNKEPEATR
PAPGPRRTGVTGGGAIPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDSGDNADTTTNTNNKAS
KVEKVSVNTTSDVTKAVNKVQDAVVSVLNYQSSSSLDGSTGSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
SSGKKSEAKLLGTDEWNDLAVLEIDDKNVSTVATFGDSDALKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAAAKAGLKQYDVIVELNGEKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKTTDIKLEAAKITT
>Mature_500_residues
MDEKEKDLNENSENESTPKREVEETLHTPESSQPVQESPIVEGVTPEGEKFAGATEEAAEASSTNAFFEEASNKEPEATR
PAPGPRRTGVTGGGAIPPNRVNNGGSGNGNGEPPKRGKHFIGYFLTALIGVIIGGLIIFFVAWDSGDNADTTTNTNNKAS
KVEKVSVNTTSDVTKAVNKVQDAVVSVLNYQSSSSLDGSTGSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
SSGKKSEAKLLGTDEWNDLAVLEIDDKNVSTVATFGDSDALKLGEPAIAIGSPLGTEFSGSVTQGIISGLNRAVPVDTNG
DGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMKISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSL
RDVDTIPETQQKNILKLPDSVDYGAMVQQVVSGSAAAKAGLKQYDVIVELNGEKVTNSMTLRKILYGNDVKIGDKVKVKY
YRDGKEKTTDIKLEAAKITT

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=297, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI24308541, Length=265, Percent_Identity=35.4716981132075, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI22129776, Length=312, Percent_Identity=32.6923076923077, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI7019477, Length=269, Percent_Identity=35.6877323420074, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI1786356, Length=288, Percent_Identity=39.5833333333333, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789629, Length=288, Percent_Identity=37.5, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI1789630, Length=381, Percent_Identity=29.3963254593176, Blast_Score=130, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24646839, Length=375, Percent_Identity=30.9333333333333, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 52797; Mature: 52797

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKEKDLNENSENESTPKREVEETLHTPESSQPVQESPIVEGVTPEGEKFAGATEEAAE
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHH
ASSTNAFFEEASNKEPEATRPAPGPRRTGVTGGGAIPPNRVNNGGSGNGNGEPPKRGKHF
HCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IGYFLTALIGVIIGGLIIFFVAWDSGDNADTTTNTNNKASKVEKVSVNTTSDVTKAVNKV
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCHHHHHHHHHHH
QDAVVSVLNYQSSSSLDGSTGSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCEEEECCCEEEEEE
SSGKKSEAKLLGTDEWNDLAVLEIDDKNVSTVATFGDSDALKLGEPAIAIGSPLGTEFSG
CCCCCCCCEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEECCCCCEEECCCCCCCCCC
SVTQGIISGLNRAVPVDTNGDGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEEE
ISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSLRDVDTIPETQQKNILKLPDS
EEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCC
VDYGAMVQQVVSGSAAAKAGLKQYDVIVELNGEKVTNSMTLRKILYGNDVKIGDKVKVKY
CCHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEECCEEEEEE
YRDGKEKTTDIKLEAAKITT
EECCCCCCCEEEEEEEECCC
>Mature Secondary Structure
MDEKEKDLNENSENESTPKREVEETLHTPESSQPVQESPIVEGVTPEGEKFAGATEEAAE
CCCCHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHH
ASSTNAFFEEASNKEPEATRPAPGPRRTGVTGGGAIPPNRVNNGGSGNGNGEPPKRGKHF
HCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
IGYFLTALIGVIIGGLIIFFVAWDSGDNADTTTNTNNKASKVEKVSVNTTSDVTKAVNKV
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHEEEEECCCHHHHHHHHHHH
QDAVVSVLNYQSSSSLDGSTGSEQEASSGSGVIYKKANGKAYIVTNNHVVADANKLEVTF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCEEEECCCEEEEEE
SSGKKSEAKLLGTDEWNDLAVLEIDDKNVSTVATFGDSDALKLGEPAIAIGSPLGTEFSG
CCCCCCCCEEECCCCCCCEEEEEECCCCCEEEEEECCCCCEECCCCCEEECCCCCCCCCC
SVTQGIISGLNRAVPVDTNGDGTEDWEADVIQTDAAINPGNSGGALINIEGQVIGINSMK
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEECCEEEEEEEEE
ISMENVEGISFAIPSNTVEPIIEQLETKGEVERPSLGVSLRDVDTIPETQQKNILKLPDS
EEECCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCEEECCCC
VDYGAMVQQVVSGSAAAKAGLKQYDVIVELNGEKVTNSMTLRKILYGNDVKIGDKVKVKY
CCHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEECCEEEEEE
YRDGKEKTTDIKLEAAKITT
EECCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]