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The map label for this gene is ntdR [H]

Identifier: 116871641

GI number: 116871641

Start: 228619

End: 229614

Strand: Direct

Name: ntdR [H]

Synonym: lwe0221

Alternate gene names: 116871641

Gene position: 228619-229614 (Clockwise)

Preceding gene: 116871640

Following gene: 116871642

Centisome position: 8.12

GC content: 32.13

Gene sequence:

>996_bases
ATGAGTAAAGTGACGAAAATTGGAGATGTAGCAGAAAAAACGGGTTATTCAATAACTACTATTTCTCGAGCAATCAATGG
TAATCCAAATGTTTCGGATAAGACAAAAAAGAAAATCTTTGCTGCGATGAAAGAATTGAATTATTATCCTAATAACATTG
CTCAACAATTTCGAGGGCAAGGAACTAAGATGATTGGTGTTGTTATTTCTTTTATTACCAATCCTTTTTTTGCGTATCTT
GTAGATGCAATTGAACGTTATTTATCTCGCGAAGGTTTTCAAGTTGTCATGTTGCAGACTTTAGAAAATCCTGCCAAAGA
ATTGCAATTCATTGAAATGTTGCAAAAGAAACAACTAGACGGTTTGATTATGGCCAACTTAGAGAATGATACAGAAGAAA
TTAAAGCTCTTGTTGAAAGTGGCAAAATCGTTCTTTGTAATCGTTACTTAGGAAATGAAAATTTAGCAATTATTAACATT
GATGAAACGAAAGCGGCTTATCAAGCAACGAATTATCTAATTGAATGTGGTTATAAGCGTCTTGCCTATTGCACAGGTGG
TATAAAAAATAAAAATGATAATCGTTTTAAAGGATTTATACAAGCTGTAATAGAAAATGGTCTTTCTTTTGATGAATCAT
TATATTTTGAAAGGTTATTAACAATTGAAGATGGGGAAAAATTACTTACTAAAATTTTAGAAGATAAAACTACGATTCCG
GATGCCTTTTTTTCAAATGGAGATACAGTTGCGGCTGGAATTTTATATGCCGCAAAAAAATATGGGATTTCAGTACCAGA
AGACTTAGGAATTATAGGTTTTGATAATCAGCCAATCGCTAAGGTGTTAAATCCAGCATTAACTACGATTGAACAGCCAA
TAAAAGAACTTGGGGAATTTTCGGCGCAAGTTTTATTAGCTAATTTACAAGGAACAAACATACCAATTGCACCAAACTTC
GAAACAAAATTAATTATAAGGGAAACTACCAAATAA

Upstream 100 bases:

>100_bases
GCATGAGAACGCAATTGGGTAAGGAAATAAGTTCTAACTTTTTCTGTAATCTGATATAATAAAGAAGTATTTGTGATTTT
GGAATATTAGGGAGATATAT

Downstream 100 bases:

>100_bases
AGTTTCTCTTATAGTCTTTATGAAAACGGTTGACATTTTGCTTGATAATTGGTATTATTTTTACGATATATGAAACCGCT
TAAACTAAAATGACAACCGG

Product: DegA family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYL
VDAIERYLSREGFQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKALVESGKIVLCNRYLGNENLAIINI
DETKAAYQATNYLIECGYKRLAYCTGGIKNKNDNRFKGFIQAVIENGLSFDESLYFERLLTIEDGEKLLTKILEDKTTIP
DAFFSNGDTVAAGILYAAKKYGISVPEDLGIIGFDNQPIAKVLNPALTTIEQPIKELGEFSAQVLLANLQGTNIPIAPNF
ETKLIIRETTK

Sequences:

>Translated_331_residues
MSKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYL
VDAIERYLSREGFQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKALVESGKIVLCNRYLGNENLAIINI
DETKAAYQATNYLIECGYKRLAYCTGGIKNKNDNRFKGFIQAVIENGLSFDESLYFERLLTIEDGEKLLTKILEDKTTIP
DAFFSNGDTVAAGILYAAKKYGISVPEDLGIIGFDNQPIAKVLNPALTTIEQPIKELGEFSAQVLLANLQGTNIPIAPNF
ETKLIIRETTK
>Mature_330_residues
SKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQGTKMIGVVISFITNPFFAYLV
DAIERYLSREGFQVVMLQTLENPAKELQFIEMLQKKQLDGLIMANLENDTEEIKALVESGKIVLCNRYLGNENLAIINID
ETKAAYQATNYLIECGYKRLAYCTGGIKNKNDNRFKGFIQAVIENGLSFDESLYFERLLTIEDGEKLLTKILEDKTTIPD
AFFSNGDTVAAGILYAAKKYGISVPEDLGIIGFDNQPIAKVLNPALTTIEQPIKELGEFSAQVLLANLQGTNIPIAPNFE
TKLIIRETTK

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=330, Percent_Identity=31.5151515151515, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787948, Length=305, Percent_Identity=31.1475409836066, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1789202, Length=299, Percent_Identity=30.4347826086957, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1790194, Length=304, Percent_Identity=30.2631578947368, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1788474, Length=326, Percent_Identity=29.4478527607362, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1789068, Length=331, Percent_Identity=26.2839879154079, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI48994940, Length=307, Percent_Identity=27.0358306188925, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1787580, Length=318, Percent_Identity=27.3584905660377, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=26.7857142857143, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1787906, Length=309, Percent_Identity=23.3009708737864, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=25.625, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790715, Length=307, Percent_Identity=22.8013029315961, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1790689, Length=313, Percent_Identity=22.0447284345048, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1789456, Length=342, Percent_Identity=21.0526315789474, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36868; Mature: 36737

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQ
CCCCHHHHHHHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GTKMIGVVISFITNPFFAYLVDAIERYLSREGFQVVMLQTLENPAKELQFIEMLQKKQLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHHHHHHCCC
GLIMANLENDTEEIKALVESGKIVLCNRYLGNENLAIINIDETKAAYQATNYLIECGYKR
CEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCHH
LAYCTGGIKNKNDNRFKGFIQAVIENGLSFDESLYFERLLTIEDGEKLLTKILEDKTTIP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
DAFFSNGDTVAAGILYAAKKYGISVPEDLGIIGFDNQPIAKVLNPALTTIEQPIKELGEF
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SAQVLLANLQGTNIPIAPNFETKLIIRETTK
HHHHEEEECCCCCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SKVTKIGDVAEKTGYSITTISRAINGNPNVSDKTKKKIFAAMKELNYYPNNIAQQFRGQ
CCCHHHHHHHHHCCCCCEEHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCC
GTKMIGVVISFITNPFFAYLVDAIERYLSREGFQVVMLQTLENPAKELQFIEMLQKKQLD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCHHHHHHHHHHHHHHCCC
GLIMANLENDTEEIKALVESGKIVLCNRYLGNENLAIINIDETKAAYQATNYLIECGYKR
CEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCHH
LAYCTGGIKNKNDNRFKGFIQAVIENGLSFDESLYFERLLTIEDGEKLLTKILEDKTTIP
HHHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCC
DAFFSNGDTVAAGILYAAKKYGISVPEDLGIIGFDNQPIAKVLNPALTTIEQPIKELGEF
HHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
SAQVLLANLQGTNIPIAPNFETKLIIRETTK
HHHHEEEECCCCCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]