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The map label for this gene is folP [C]

Identifier: 116871608

GI number: 116871608

Start: 189085

End: 189900

Strand: Direct

Name: folP [C]

Synonym: lwe0188

Alternate gene names: 116871608

Gene position: 189085-189900 (Clockwise)

Preceding gene: 116871606

Following gene: 116871609

Centisome position: 6.72

GC content: 40.2

Gene sequence:

>816_bases
TTGAAGAAGTGGAAAAGGGATCACCTAGGTATGGTCATGGGAATATTAAACGTTACACCAGATTCTTTTTCGGATGGTGG
GAAATATATGCAAGTGGAAAAAGCCGTAGAGCAAGCCTTACAAATGGCTAAGGATGGGGCTGGGATTATTGATGTTGGTG
GAATCTCTACCCGTCCTGGATTTTCAGAAGTAAGCCCTCAAGAAGAACTTGCCCGGATTATTCCAGTTATTAAATCTATT
AGAGAAAAACTGCCCAATATATGGATTTCTGTTGATTCTTGGCGCGCAGAAGTAGCTGAACAAGCGATTTTAGCGGGAGC
TGATATGATAAATGATCAATGGGGTGCGAAAAAAGAACCAAAAATTGCAGAAGTTGCTGCAAAATACAATGTACCAATCT
GTTTAATGCATAACCGTGAAAATACGCAATATACAAATTTTCTAGAAGATGTTAAAAAAGATTTGCTAGAGAGTGTGGCG
ATTGCTAAAGCGGCATCAGTACCGGATGAACATATCATTCTTGATCCAGGTTTTGGCTTTGTTAAAACGCCCGCTCAGAA
TTTAGAAGTGTTAAGACGCATTGATGAGATTGTTGCGCTTGGTTATGAGGTTTTACTTGGAACGAGTCGAAAATCAACTA
TTGGACTTGTCCTTGGAACTACTCCAGAAGATAGAATGGAAGGAACTGGAGCAACGACAGTTTACGGATTTGCCAAGGGC
TGTACAATTACTCGGGTACATGATGTGCTCCCGGTAGCTCGTATGGTTCGAATGACAGATGCGATTACAGGTAAATTAGA
TATTACAAAATTATAA

Upstream 100 bases:

>100_bases
TTTTGACCGATGCGGTTTACTCCCTTTTCCGCATCGGTTTTTTTGTGCGCTAAAATCACTGAATTCTGCTATAATAAATC
TCGGAAAGAGGTGTTTGTAC

Downstream 100 bases:

>100_bases
AGAGGTGCTTTGGTTGGATAAAATTTATTTAAATGAGTTAGCGTTTTATGGATACCACGGAGTTTTAGCAGAAGAAACAA
AATTAGGACAAACATTTAAA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEKAVEQALQMAKDGAGIIDVGGISTRPGFSEVSPQEELARIIPVIKSI
REKLPNIWISVDSWRAEVAEQAILAGADMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYTNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFAKG
CTITRVHDVLPVARMVRMTDAITGKLDITKL

Sequences:

>Translated_271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEKAVEQALQMAKDGAGIIDVGGISTRPGFSEVSPQEELARIIPVIKSI
REKLPNIWISVDSWRAEVAEQAILAGADMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYTNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFAKG
CTITRVHDVLPVARMVRMTDAITGKLDITKL
>Mature_271_residues
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEKAVEQALQMAKDGAGIIDVGGISTRPGFSEVSPQEELARIIPVIKSI
REKLPNIWISVDSWRAEVAEQAILAGADMINDQWGAKKEPKIAEVAAKYNVPICLMHNRENTQYTNFLEDVKKDLLESVA
IAKAASVPDEHIILDPGFGFVKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFAKG
CTITRVHDVLPVARMVRMTDAITGKLDITKL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=257, Percent_Identity=42.0233463035019, Blast_Score=196, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6324073, Length=320, Percent_Identity=31.25, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29719; Mature: 29719

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEKAVEQALQMAKDGAGIIDVGGISTRPG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
FSEVSPQEELARIIPVIKSIREKLPNIWISVDSWRAEVAEQAILAGADMINDQWGAKKEP
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KIAEVAAKYNVPICLMHNRENTQYTNFLEDVKKDLLESVAIAKAASVPDEHIILDPGFGF
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
VKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFAKG
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHCCCCCCEEEHHHCC
CTITRVHDVLPVARMVRMTDAITGKLDITKL
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MKKWKRDHLGMVMGILNVTPDSFSDGGKYMQVEKAVEQALQMAKDGAGIIDVGGISTRPG
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
FSEVSPQEELARIIPVIKSIREKLPNIWISVDSWRAEVAEQAILAGADMINDQWGAKKEP
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KIAEVAAKYNVPICLMHNRENTQYTNFLEDVKKDLLESVAIAKAASVPDEHIILDPGFGF
HHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
VKTPAQNLEVLRRIDEIVALGYEVLLGTSRKSTIGLVLGTTPEDRMEGTGATTVYGFAKG
CCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCHHHHCCCCCCEEEHHHCC
CTITRVHDVLPVARMVRMTDAITGKLDITKL
CCHHHHHHHHHHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]