Click here to switch to the map view.

The map label for this gene is glmU [H]

Identifier: 116871587

GI number: 116871587

Start: 166369

End: 167742

Strand: Direct

Name: glmU [H]

Synonym: lwe0167

Alternate gene names: 116871587

Gene position: 166369-167742 (Clockwise)

Preceding gene: 116871586

Following gene: 116871588

Centisome position: 5.91

GC content: 38.36

Gene sequence:

>1374_bases
ATGTCAAAACGATATGCTGTAGTGCTTGCTGCTGGTCAAGGCACACGGATGAAGTCGAAACTTTACAAAGTGTTGCACCC
GGTTTGTGGAAAACCAATGGTCGAACATGTAGTAGACCAAATTTCAACGCTTGATGTTGATAAAGTGGTTACAATTGTAG
GTCATGGAGCTGAGAAAGTACAAGAGCATTTAGCTGGTAAAAGTGAGTTTGTGAAGCAAGAAGAGCAATTAGGAACAGCT
CATGCGGTACTTCAAGCGAAACCAGAACTTGCTGGAAAAGACGGTGTGACGTTAGTTGTTTGTGGAGATACACCTTTAAT
CGAAGCTAGCACAATGGAAGCTTTGCTAAAATATCACCATGAAAAACGCGCAAAAGCAACAATCCTTACAACAGTTATTG
AAGACCCTACAGGTTATGGCCGAATTATTCGAGATGACCTTGGTATTGTAGAAAAAATTGTAGAACATAAAGATGCAACA
GAAAAAGAGCAACGCATTTCAGAAATCAACACTGGTACATATTGCTTTGATAACAAAGCGCTTTTTGAAGCATTAGAAAA
TGTCTCTAATGATAATGTTCAAGGAGAATATTACTTGCCAGATGTTATTAAAATTTTAAAAGATTTGGATGAAGTTGTAG
CAGCATATAGAATGGAATCTTTCGAGGAATCTCTTGGGGTTAACGATAGAATTGCTCTAGCTGAAGCTTCTAAATTAATG
CAACGTCGAATCAATGATAATCATATGCGGAATGGAGTAACGCTTGTTAATCCAGAAAATACGTATATTGATATAGATGT
AAAAATTGGTCAGGATACAGTAATTGAACCGGGAGTTATGCTTCGCGGAAATACTGTGATTGGTGATGACTGTGTGATTT
CAAGTGGTTCAGAAATTGCCAACAGCGTTATTGGTGAACGAGTTCATGTCAGAAATTCCTCCATTTTTGAAAGTAAAGTT
GGAGATGACGTTCAAATCGGGCCATATGCTCATCTAAGACCTGAATCTGATATTCATAATCATGTGAAAATCGGAAATTA
CGTCGAAACAAAAAAAGCGATTGTTGGTGAAGGAACTAAATTACCACATTTCATTTATATGGGAGATGCGGAAATTGGTA
AGAATGTCAATGTTGGTTGCGGAAGTATTGCTGTTAATTACGACGGCAAAAACAAGGCGAAAACCATTATTGGAGATGAC
GTTTTTGTAGGTTGTAATTCAAATCTAATTGCACCTGTCAAAGTGGGAGACCGTGCTTTCATAGCAGCTGGTTCAACCAT
TACAAAAGATGTTCCAGAAGATGCGCTAGGAATTGCTCGCGCGAAACAAGAGAACAAGATGGACTATGCGAAGCGTCTAA
ATCACGGTAAATAA

Upstream 100 bases:

>100_bases
ATAAGGGTGGGAGTTTTTATTTGGTCGTATTCTTGAAAAAAAGCGGATTTTACGTTATCATTCATAGTGGATGAATAGTG
AATATTGGAGGTCCTATATA

Downstream 100 bases:

>100_bases
TTTCCAATTGGAAAGTTTAAAATTTTAATAAAAAATAGTGGAGGCTGATTATGTCAAACGAGTATTTTGATCCAAAGTTG
AAGATTTTCTCGCTAAATTC

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLDVDKVVTIVGHGAEKVQEHLAGKSEFVKQEEQLGTA
HAVLQAKPELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDAT
EKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDLDEVVAAYRMESFEESLGVNDRIALAEASKLM
QRRINDNHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGNTVIGDDCVISSGSEIANSVIGERVHVRNSSIFESKV
GDDVQIGPYAHLRPESDIHNHVKIGNYVETKKAIVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDD
VFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQENKMDYAKRLNHGK

Sequences:

>Translated_457_residues
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLDVDKVVTIVGHGAEKVQEHLAGKSEFVKQEEQLGTA
HAVLQAKPELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDAT
EKEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDLDEVVAAYRMESFEESLGVNDRIALAEASKLM
QRRINDNHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGNTVIGDDCVISSGSEIANSVIGERVHVRNSSIFESKV
GDDVQIGPYAHLRPESDIHNHVKIGNYVETKKAIVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDD
VFVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQENKMDYAKRLNHGK
>Mature_456_residues
SKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLDVDKVVTIVGHGAEKVQEHLAGKSEFVKQEEQLGTAH
AVLQAKPELAGKDGVTLVVCGDTPLIEASTMEALLKYHHEKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATE
KEQRISEINTGTYCFDNKALFEALENVSNDNVQGEYYLPDVIKILKDLDEVVAAYRMESFEESLGVNDRIALAEASKLMQ
RRINDNHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGNTVIGDDCVISSGSEIANSVIGERVHVRNSSIFESKVG
DDVQIGPYAHLRPESDIHNHVKIGNYVETKKAIVGEGTKLPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDDV
FVGCNSNLIAPVKVGDRAFIAAGSTITKDVPEDALGIARAKQENKMDYAKRLNHGK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc [H]

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1790168, Length=447, Percent_Identity=40.9395973154362, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI133931050, Length=347, Percent_Identity=26.2247838616715, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=375, Percent_Identity=24.2666666666667, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355443, Length=342, Percent_Identity=24.2690058479532, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24644084, Length=342, Percent_Identity=24.2690058479532, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 49956; Mature: 49824

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLDVDKVVTIVGHGAEKV
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHEECCCHHHH
QEHLAGKSEFVKQEEQLGTAHAVLQAKPELAGKDGVTLVVCGDTPLIEASTMEALLKYHH
HHHHCCHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKA
HHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHH
LFEALENVSNDNVQGEYYLPDVIKILKDLDEVVAAYRMESFEESLGVNDRIALAEASKLM
HHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
QRRINDNHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGNTVIGDDCVISSGSEIA
HHHCCCCHHHCCEEEECCCCCEEEEEEEECCCCEECCCEEEECCEEECCCCEECCCHHHH
NSVIGERVHVRNSSIFESKVGDDVQIGPYAHLRPESDIHNHVKIGNYVETKKAIVGEGTK
HHHHCCEEEECCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCC
LPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDDVFVGCNSNLIAPVKVGDRAF
CCEEEEECCHHHCCCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCEEEEEEECCEEE
IAAGSTITKDVPEDALGIARAKQENKMDYAKRLNHGK
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SKRYAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDQISTLDVDKVVTIVGHGAEKV
CCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHEECCCHHHH
QEHLAGKSEFVKQEEQLGTAHAVLQAKPELAGKDGVTLVVCGDTPLIEASTMEALLKYHH
HHHHCCHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHH
EKRAKATILTTVIEDPTGYGRIIRDDLGIVEKIVEHKDATEKEQRISEINTGTYCFDNKA
HHHHHHEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECCHH
LFEALENVSNDNVQGEYYLPDVIKILKDLDEVVAAYRMESFEESLGVNDRIALAEASKLM
HHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHH
QRRINDNHMRNGVTLVNPENTYIDIDVKIGQDTVIEPGVMLRGNTVIGDDCVISSGSEIA
HHHCCCCHHHCCEEEECCCCCEEEEEEEECCCCEECCCEEEECCEEECCCCEECCCHHHH
NSVIGERVHVRNSSIFESKVGDDVQIGPYAHLRPESDIHNHVKIGNYVETKKAIVGEGTK
HHHHCCEEEECCCCHHHHHCCCCEEECCCCCCCCCCCCCCCEECCCHHHHHHHHHCCCCC
LPHFIYMGDAEIGKNVNVGCGSIAVNYDGKNKAKTIIGDDVFVGCNSNLIAPVKVGDRAF
CCEEEEECCHHHCCCCCCCCCEEEEEECCCCCCEEEECCCEEEECCCCEEEEEEECCEEE
IAAGSTITKDVPEDALGIARAKQENKMDYAKRLNHGK
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]