Click here to switch to the map view.

The map label for this gene is 116871435

Identifier: 116871435

GI number: 116871435

Start: 14792

End: 15874

Strand: Direct

Name: 116871435

Synonym: lwe0013

Alternate gene names: NA

Gene position: 14792-15874 (Clockwise)

Preceding gene: 116871434

Following gene: 116871436

Centisome position: 0.53

GC content: 37.77

Gene sequence:

>1083_bases
GTGTTATATCAGATGAAAAATAAACTACAGGTTAAAATACCCGGAAAATTATATGTTGCTGGTGAATACGCAGTTGTAGA
ATCCGGTCATACAGCCATTTTAACAGCTGTTAATCGTTATATAACGTTGACACTCGAAGATAGTGATCGTAATGAATTAT
GGATTCCTCACTATGAAAATCCAGTTTCATGGCCGGTTGGCGGAGAACTCAAACCGGACGGGGAACATTGGACGTTTACA
GCTGAAGCAATTAATATTGCGACAACTTTCTTAAAATCAGAAGGCATCGAGCTAACTCCGGTGAAAATGGTTATTGAAAC
AGAATTAATCGACCAATCTGGAGCTAAATATGGACTAGGTTCGAGCGCAGCAGCAACAGTAGCTGTAATCAACGCGCTAA
TGACTAAATTTTATCCTGAAATATCTATGTTAAAAAAATTCAAATTAGCTGCACTTTCGCATTTAGTAGTACAAGGGAAT
GGTTCTTGTGGGGATATTGCTTCTTGTATGTACGGTGGCTGGATTGCTTACACTACATTTGATCAAGAATGGGTGAAGCA
TCGTTTAGCTTATAAATCACTCGAATGGTTTATGAAAGAGCCATGGCCAATGCTTCAAATCGAAACATTAGAAGAACCAG
TCCCGACTTTTTCTGTTGGATGGACGGGTACACCTGTTAGTACTGGAAAACTTGTTTCGCAAATTCATGCGTTTAAACAA
GAAGATAGCAAGAATTACCAACATTTCTTAACTAGAAATAATGAGATAATGAAGCAAATAATTCAAGCTTTCCATACGAA
AGATGAGGAACTGCTTTATTCATCAATTAAAGAAAATCGTCGCATCCTTCAAGAACTTGGAACAAAAGCTGGTGTAAATA
TTGAAACTAGCTTATTAAAAGAACTAGCTGACTCAGCTGAAAACTTTGGTGGAGCAGGAAAATCTTCTGGTTCTGGCGGT
GGAGATTGTGGTATAGCTTTCTCAAAAACAAAGGAACTAGCCGAAAAACTAGTTAATGAATGGGAAACCCTTGGTATTAA
GCATTTACCTTTCCATACAGGGAGAGTGCAAATTACTGAATAA

Upstream 100 bases:

>100_bases
GTTAAAGTGATTTGTGAGCGCGAAAATGAAAATATCGTAGCAGAGAAGTTGTCAGGTTTGGCTAAAAATGTTCTAATTTG
CCACGCTGGTAAGGAAGCGA

Downstream 100 bases:

>100_bases
AATTTAAGCAGCAAACTAAGATAAATTGTTTGTTGCTTTTTTTGTTTTAAATTTCACAATCAAGGGAATAGTCAACAGAA
CGAAAGTTTGTGAAATATTT

Product: phosphomevalonate kinase

Products: ADP; (R)-5-diphosphomevalonate

Alternate protein names: Mevalonate Kinase; LOW QUALITY PROTEIN Phosphomevalonate Kinase; Isopentenyl-Diphosphate Delta-Isomerase

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MLYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSDRNELWIPHYENPVSWPVGGELKPDGEHWTFT
AEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGN
GSCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQ
EDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENFGGAGKSSGSGG
GDCGIAFSKTKELAEKLVNEWETLGIKHLPFHTGRVQITE

Sequences:

>Translated_360_residues
MLYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSDRNELWIPHYENPVSWPVGGELKPDGEHWTFT
AEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGN
GSCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQ
EDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENFGGAGKSSGSGG
GDCGIAFSKTKELAEKLVNEWETLGIKHLPFHTGRVQITE
>Mature_360_residues
MLYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSDRNELWIPHYENPVSWPVGGELKPDGEHWTFT
AEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLGSSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGN
GSCGDIASCMYGGWIAYTTFDQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQ
EDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLKELADSAENFGGAGKSSGSGG
GDCGIAFSKTKELAEKLVNEWETLGIKHLPFHTGRVQITE

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.4.2

Molecular weight: Translated: 40071; Mature: 40071

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSDRNELWIPHYEN
CCCCCCCCEEEEECCEEEEECCEEEEECCCCCEEEEECEEEEEEEECCCCCCEECCCCCC
PVSWPVGGELKPDGEHWTFTAEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLG
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHEEEEEHHHHHCCCCCCCCC
SSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNGSCGDIASCMYGGWIAYTTF
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEECC
DQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQ
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
EDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLK
HCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ELADSAENFGGAGKSSGSGGGDCGIAFSKTKELAEKLVNEWETLGIKHLPFHTGRVQITE
HHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECC
>Mature Secondary Structure
MLYQMKNKLQVKIPGKLYVAGEYAVVESGHTAILTAVNRYITLTLEDSDRNELWIPHYEN
CCCCCCCCEEEEECCEEEEECCEEEEECCCCCEEEEECEEEEEEEECCCCCCEECCCCCC
PVSWPVGGELKPDGEHWTFTAEAINIATTFLKSEGIELTPVKMVIETELIDQSGAKYGLG
CCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHCCCCEEEHHEEEEEHHHHHCCCCCCCCC
SSAAATVAVINALMTKFYPEISMLKKFKLAALSHLVVQGNGSCGDIASCMYGGWIAYTTF
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCEEEEECC
DQEWVKHRLAYKSLEWFMKEPWPMLQIETLEEPVPTFSVGWTGTPVSTGKLVSQIHAFKQ
CHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHH
EDSKNYQHFLTRNNEIMKQIIQAFHTKDEELLYSSIKENRRILQELGTKAGVNIETSLLK
HCCCCHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ELADSAENFGGAGKSSGSGGGDCGIAFSKTKELAEKLVNEWETLGIKHLPFHTGRVQITE
HHHHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-phosphomevalonate

Specific reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA