Click here to switch to the map view.

The map label for this gene is mvaD

Identifier: 116871434

GI number: 116871434

Start: 13843

End: 14814

Strand: Direct

Name: mvaD

Synonym: lwe0012

Alternate gene names: NA

Gene position: 13843-14814 (Clockwise)

Preceding gene: 116871433

Following gene: 116871435

Centisome position: 0.49

GC content: 38.79

Gene sequence:

>972_bases
ATGAGAGCGACAGCCATCGCACACACGAATGTGGCGCTAATTAAATACTGGGGAAAACGCGATGAACACTTGATTCTACC
TGCAAACAGTAGTTTATCCTTTACGGTAGATAAATTTTATACAAAAACAACGGTAGAATGGGACAAAAACTCAGCCCAAG
ATACATTTATTTTAAATGGTGAACAAAAAACGGATGCAAAAGTAGCTCGTTTTATAGATAAAATGCGAGAAGAATTTGGT
ATTACATCAAAGGCAATAATAACTTCTGAAAACCACGTTCCGACTGCTGCTGGACTTGCTTCATCAGCTTCGGCGTTTGC
GGCCCTTGCACTTGCAGGATCCAGTGCTGCCGGTAGGGATGATACAAAAGAATATATTTCCAGACTAGCGCGTTTTGGTT
CTGGGTCTGCTTCTCGTTCGGTTTTTGGTGATTTTGTTATTTGGGAAAAAGGGCAACAACCAGATGGCAATGATTCATTT
GCAATTCCTTTTACCAATAAATTATGCGATAAAATGTCATTAGTAGTTGCAGTCGTTTCTGACAAAGAAAAGAAAGTTTC
CAGTCGTGATGGAATGCGTTTAACCGTAGAAACATCTCCGTTTTTTGAAAAATGGGTATCTGCTGCTGAAACTGATTTAG
AAGAAATGAAAAAAGCAATTTTAAACGAAGATTTTATCAAAGTTGGTGAAATTACAGAACGAAATGGAATGAAAATGCAT
GCGACAACACTTGGTGCAGAACCTCCTTTTACGTATTTTCAACCTCAGTCACTCGAAATAATGGACGCTGTTAGAGAACT
ACGCGAAAATGGCATACCAGCCTATTTTACAATGGATGCAGGTCCGAATGTTAAAGTGATTTGTGAGCGCGAAAATGAAA
ATATCGTAGCAGAGAAGTTGTCAGGTTTGGCTAAAAATGTTCTAATTTGCCACGCTGGTAAGGAAGCGAGTGTTATATCA
GATGAAAAATAA

Upstream 100 bases:

>100_bases
GCTGTAGCAAAAAATCAAGAAATCGCTGAACAAATAACGAAGGCGCTTCATAATGCTGGAGCTGCACAAGAATGGATTTT
TACGATTGGAGAAGGTAGTT

Downstream 100 bases:

>100_bases
ACTACAGGTTAAAATACCCGGAAAATTATATGTTGCTGGTGAATACGCAGTTGTAGAATCCGGTCATACAGCCATTTTAA
CAGCTGTTAATCGTTATATA

Product: mevalonate diphosphate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; GHMP Kinase; GHMP Kinase Domain-Containing Protein; Phosphomevalonate Kinase; Ghmp Kinase

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MRATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDKNSAQDTFILNGEQKTDAKVARFIDKMREEFG
ITSKAIITSENHVPTAAGLASSASAFAALALAGSSAAGRDDTKEYISRLARFGSGSASRSVFGDFVIWEKGQQPDGNDSF
AIPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKKAILNEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPQSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVAEKLSGLAKNVLICHAGKEASVIS
DEK

Sequences:

>Translated_323_residues
MRATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDKNSAQDTFILNGEQKTDAKVARFIDKMREEFG
ITSKAIITSENHVPTAAGLASSASAFAALALAGSSAAGRDDTKEYISRLARFGSGSASRSVFGDFVIWEKGQQPDGNDSF
AIPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKKAILNEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPQSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVAEKLSGLAKNVLICHAGKEASVIS
DEK
>Mature_323_residues
MRATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDKNSAQDTFILNGEQKTDAKVARFIDKMREEFG
ITSKAIITSENHVPTAAGLASSASAFAALALAGSSAAGRDDTKEYISRLARFGSGSASRSVFGDFVIWEKGQQPDGNDSF
AIPFTNKLCDKMSLVVAVVSDKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKKAILNEDFIKVGEITERNGMKMH
ATTLGAEPPFTYFQPQSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVAEKLSGLAKNVLICHAGKEASVIS
DEK

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=306, Percent_Identity=35.6209150326797, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17537201, Length=314, Percent_Identity=34.0764331210191, Blast_Score=144, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17537203, Length=175, Percent_Identity=33.7142857142857, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324371, Length=313, Percent_Identity=38.6581469648562, Blast_Score=154, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28571205, Length=319, Percent_Identity=35.1097178683386, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 35512; Mature: 35512

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDKNSAQDTFILNG
CCCCEEECCCEEEEEECCCCCCEEEEECCCCCEEEHHHHEEEEEEEECCCCCCCEEEECC
EQKTDAKVARFIDKMREEFGITSKAIITSENHVPTAAGLASSASAFAALALAGSSAAGRD
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DTKEYISRLARFGSGSASRSVFGDFVIWEKGQQPDGNDSFAIPFTNKLCDKMSLVVAVVS
HHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCCCCCCEEECCHHHHHHHHHEEEEEEC
DKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKKAILNEDFIKVGEITERNGMKMH
CCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEECCCCCEEE
ATTLGAEPPFTYFQPQSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVAEKL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHHHHH
SGLAKNVLICHAGKEASVISDEK
HHHHHCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRATAIAHTNVALIKYWGKRDEHLILPANSSLSFTVDKFYTKTTVEWDKNSAQDTFILNG
CCCCEEECCCEEEEEECCCCCCEEEEECCCCCEEEHHHHEEEEEEEECCCCCCCEEEECC
EQKTDAKVARFIDKMREEFGITSKAIITSENHVPTAAGLASSASAFAALALAGSSAAGRD
CCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
DTKEYISRLARFGSGSASRSVFGDFVIWEKGQQPDGNDSFAIPFTNKLCDKMSLVVAVVS
HHHHHHHHHHHHCCCCCCHHHHCCEEEEECCCCCCCCCCEEECCHHHHHHHHHEEEEEEC
DKEKKVSSRDGMRLTVETSPFFEKWVSAAETDLEEMKKAILNEDFIKVGEITERNGMKMH
CCHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEECCCCCEEE
ATTLGAEPPFTYFQPQSLEIMDAVRELRENGIPAYFTMDAGPNVKVICERENENIVAEKL
EEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHHHHH
SGLAKNVLICHAGKEASVISDEK
HHHHHCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA