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The map label for this gene is mvk [H]

Identifier: 116871433

GI number: 116871433

Start: 12918

End: 13886

Strand: Direct

Name: mvk [H]

Synonym: lwe0011

Alternate gene names: 116871433

Gene position: 12918-13886 (Clockwise)

Preceding gene: 116871432

Following gene: 116871434

Centisome position: 0.46

GC content: 38.49

Gene sequence:

>969_bases
TTGGCTACAGGCATTGGGACAGCTAAAATGATATTATGCGGAGAACATGCAGTTGTATACGGAGAACCGGCGATTTCAGT
CCCATTTACACAAGCAGTAGTAACAACAAATGTAGAAACTTCTACAAAAACCAGATTTTCTTCAGCATTTTTTACAGGTG
ATTTAGAAGATATGCCAGATTTCTTAGCAGGAATCAAAGCATTAGTTATTGATGTTTTAAATGAAATTGGCAAAGGTGAA
TGTGTATCTATTCATGTAACTTCAGGCGTTCCAATTGGACGAGGATTAGGTTCAAGTGCTGCAGTAGCGACTAGTATTGC
GCGTGGCCTATATAAATATTTCAATCAAAAATTAGACTCAAAAAAATTATTAGCAATAGTTAATGATGCAGAAAAAATTG
CTCATGGTAATGCTAGTGGTGTTGATGCTATTACGGTCGTGAGTGAAAAGCCAGTTTGGTATGAACGAGACCGGAAATTA
GAAATCATGCACTTTCCTAAAAAAATTACGTTCGTAGTAGCAGATACTGGGGTGCCAAGTGAAACCAGGGATGCCGTTAA
GGATGTCCAAGTTTTATATAAAGAAAATCAAGCTGAAATCGGAAAAATAATTCAACAACTAGGGGATATTTCCCGGGAAA
TAAAGCACCATTTAGAAGGCGATGCAGATACCGTGAAGATTGGTGCTGCAATGAATAGAGCTCAGTCTTATTTGGAAACT
TTGACAGTTAGTGATAGTAGTTTAGAAAAATTAATTAAAGTAGCTAGAAATAGTGGTGCAGATGGGGCGAAACTTACAGG
TGGCGGTAGAGGTGGATGTATTATCGCTGTAGCAAAAAATCAAGAAATCGCTGAACAAATAACGAAGGCGCTTCATAATG
CTGGAGCTGCACAAGAATGGATTTTTACGATTGGAGAAGGTAGTTATGAGAGCGACAGCCATCGCACACACGAATGTGGC
GCTAATTAA

Upstream 100 bases:

>100_bases
GGGTCAAAAAAAGTTCTATAATAAGGTTTTAGTGAAAAAATTATGGTATCATGAAGTATTAAAGTTTGTATTATTTTGAT
GGAGAAAGGATTGGCGTGCA

Downstream 100 bases:

>100_bases
ATACTGGGGAAAACGCGATGAACACTTGATTCTACCTGCAAACAGTAGTTTATCCTTTACGGTAGATAAATTTTATACAA
AAACAACGGTAGAATGGGAC

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSTKTRFSSAFFTGDLEDMPDFLAGIKALVIDVLNEIGKGE
CVSIHVTSGVPIGRGLGSSAAVATSIARGLYKYFNQKLDSKKLLAIVNDAEKIAHGNASGVDAITVVSEKPVWYERDRKL
EIMHFPKKITFVVADTGVPSETRDAVKDVQVLYKENQAEIGKIIQQLGDISREIKHHLEGDADTVKIGAAMNRAQSYLET
LTVSDSSLEKLIKVARNSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEWIFTIGEGSYESDSHRTHECG
AN

Sequences:

>Translated_322_residues
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSTKTRFSSAFFTGDLEDMPDFLAGIKALVIDVLNEIGKGE
CVSIHVTSGVPIGRGLGSSAAVATSIARGLYKYFNQKLDSKKLLAIVNDAEKIAHGNASGVDAITVVSEKPVWYERDRKL
EIMHFPKKITFVVADTGVPSETRDAVKDVQVLYKENQAEIGKIIQQLGDISREIKHHLEGDADTVKIGAAMNRAQSYLET
LTVSDSSLEKLIKVARNSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEWIFTIGEGSYESDSHRTHECG
AN
>Mature_321_residues
ATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSTKTRFSSAFFTGDLEDMPDFLAGIKALVIDVLNEIGKGEC
VSIHVTSGVPIGRGLGSSAAVATSIARGLYKYFNQKLDSKKLLAIVNDAEKIAHGNASGVDAITVVSEKPVWYERDRKLE
IMHFPKKITFVVADTGVPSETRDAVKDVQVLYKENQAEIGKIIQQLGDISREIKHHLEGDADTVKIGAAMNRAQSYLETL
TVSDSSLEKLIKVARNSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEWIFTIGEGSYESDSHRTHECGA
N

Specific function: Galactose metabolism; first step. [C]

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 34360; Mature: 34229

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSTKTRFSSAFFTGDLEDMPD
CCCCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHEECCCHHHHHH
FLAGIKALVIDVLNEIGKGECVSIHVTSGVPIGRGLGSSAAVATSIARGLYKYFNQKLDS
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
KKLLAIVNDAEKIAHGNASGVDAITVVSEKPVWYERDRKLEIMHFPKKITFVVADTGVPS
CCEEEEECCHHHHHCCCCCCCEEEEEEECCCCEECCCCEEEEEECCCEEEEEEECCCCCC
ETRDAVKDVQVLYKENQAEIGKIIQQLGDISREIKHHLEGDADTVKIGAAMNRAQSYLET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
LTVSDSSLEKLIKVARNSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEW
HHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEE
IFTIGEGSYESDSHRTHECGAN
EEEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATGIGTAKMILCGEHAVVYGEPAISVPFTQAVVTTNVETSTKTRFSSAFFTGDLEDMPD
CCCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHEECCCHHHHHH
FLAGIKALVIDVLNEIGKGECVSIHVTSGVPIGRGLGSSAAVATSIARGLYKYFNQKLDS
HHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
KKLLAIVNDAEKIAHGNASGVDAITVVSEKPVWYERDRKLEIMHFPKKITFVVADTGVPS
CCEEEEECCHHHHHCCCCCCCEEEEEEECCCCEECCCCEEEEEECCCEEEEEEECCCCCC
ETRDAVKDVQVLYKENQAEIGKIIQQLGDISREIKHHLEGDADTVKIGAAMNRAQSYLET
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHH
LTVSDSSLEKLIKVARNSGADGAKLTGGGRGGCIIAVAKNQEIAEQITKALHNAGAAQEW
HHCCHHHHHHHHHHHHCCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEE
IFTIGEGSYESDSHRTHECGAN
EEEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]