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The map label for this gene is ada [H]

Identifier: 116691169

GI number: 116691169

Start: 3471095

End: 3472054

Strand: Reverse

Name: ada [H]

Synonym: Bcen2424_3151

Alternate gene names: 116691169

Gene position: 3472054-3471095 (Counterclockwise)

Preceding gene: 116691170

Following gene: 116691168

Centisome position: 99.66

GC content: 72.4

Gene sequence:

>960_bases
TTGAGCATCGACACGACAACGATTACCTCCCTCGCGAACGGCGGCCCTGTGCCGCCGTCCGCGCAGATGGAGCTGCGCTA
CAAGGCGCCGTACGACTGGGCGCGCGTGCTGCGCTTCTTCAGCGGGCGCGCGATTCCGGGCGTCGAGCAGGTCGCGGACG
GCGTGTATCGCCGCATTGTCGATCTGCACGGCGATGCGGGCCGGCTCACCGTCACGAAACATCCGCGCAAGCATTGCCTG
ATCGCGACCGTCGAAGGGGCGGTCGCGCGTCACGTCGACGATGCGTTCGCCGCACGCGTCGCGACGATGTTCGACCTCGG
CGCCGATCCGGCCGCGATCGGCGGCGACCTCGCGCGCGATCCGTGGTTCGCGCCGCTCGTCGAGGCCGCGCCGGGGCTGC
GCGTGCCGGGTGCGTGGTCGGGGTTCGAGCTGGCCGTGCGCGCGATCGTCGGCCAGCAGGTGAGCGTGAAGGCCGCGACG
ACGATCGTTGGCCGGCTCGTCGAACGGGCCGGCGAACGTGTGATTCATGAAGACGACGGCGCGCCCGCGTGGCGGTTCCC
GACGCCCGACGCGCTGGCCGCGTGCGATCTCGACAAGATCGGGATGCCCGGCAAGCGCGTGGCCGCGCTGACCGGCGTGG
CGCGCGCGGTGGCGGCCGGCGACGTGCCGGTCGATCGTGCGCATGCCGACCTCGCGATGCTGCGCAGCGCGTGGCTCGAG
CTGCCCGGCATCGGCCCGTGGACGGTCGAATACATCGCGATGCGCGCATGGCGCGACCCGGACGCGTGGCCGGCATCCGA
TCTCGTGCTGATGCAGTCGATCGCCGCGCGCGACCCGGCGCTCGACCGGCTCGCCAGCCAGAAGCACCGCACCGAAGGCT
GGCGGCCGTGGCGTGCGTATGCGGCGTTGCATCTGTGGAACGACGTGGCCGACCGGGCAGGCGGCGCGCGCGGCGGGTAA

Upstream 100 bases:

>100_bases
GCTATCGCTGGGGCGTGCGCCGCAAGGCGACGCTGCTCGCGGCCGAGGCGCGCCATGTTCACAACGATGAAGCCGAAGCC
GAGACGGAGGACAGTGCGGT

Downstream 100 bases:

>100_bases
GCACGCCGCGGCAGGGGACGACCGCAAGGAGGCGGCGCCGCAACCCGTCGCGCACGCGGTGCCGGCATGCGGCAAGCGCC
GGGGCGTGACGCGGCGCCGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSIDTTTITSLANGGPVPPSAQMELRYKAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVTKHPRKHCL
IATVEGAVARHVDDAFAARVATMFDLGADPAAIGGDLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAAT
TIVGRLVERAGERVIHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDRAHADLAMLRSAWLE
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSIAARDPALDRLASQKHRTEGWRPWRAYAALHLWNDVADRAGGARGG

Sequences:

>Translated_319_residues
MSIDTTTITSLANGGPVPPSAQMELRYKAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVTKHPRKHCL
IATVEGAVARHVDDAFAARVATMFDLGADPAAIGGDLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAAT
TIVGRLVERAGERVIHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDRAHADLAMLRSAWLE
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSIAARDPALDRLASQKHRTEGWRPWRAYAALHLWNDVADRAGGARGG
>Mature_318_residues
SIDTTTITSLANGGPVPPSAQMELRYKAPYDWARVLRFFSGRAIPGVEQVADGVYRRIVDLHGDAGRLTVTKHPRKHCLI
ATVEGAVARHVDDAFAARVATMFDLGADPAAIGGDLARDPWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATT
IVGRLVERAGERVIHEDDGAPAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDRAHADLAMLRSAWLEL
PGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSIAARDPALDRLASQKHRTEGWRPWRAYAALHLWNDVADRAGGARGG

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=285, Percent_Identity=35.4385964912281, Blast_Score=154, Evalue=9e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 34260; Mature: 34129

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDTTTITSLANGGPVPPSAQMELRYKAPYDWARVLRFFSGRAIPGVEQVADGVYRRIV
CCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DLHGDAGRLTVTKHPRKHCLIATVEGAVARHVDDAFAARVATMFDLGADPAAIGGDLARD
HHCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
PWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATTIVGRLVERAGERVIHEDDG
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
APAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDRAHADLAMLRSAWLE
CCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSIAARDPALDRLASQKHRTEGWRPWRAY
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
AALHLWNDVADRAGGARGG
HHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SIDTTTITSLANGGPVPPSAQMELRYKAPYDWARVLRFFSGRAIPGVEQVADGVYRRIV
CCCHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DLHGDAGRLTVTKHPRKHCLIATVEGAVARHVDDAFAARVATMFDLGADPAAIGGDLARD
HHCCCCCEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCC
PWFAPLVEAAPGLRVPGAWSGFELAVRAIVGQQVSVKAATTIVGRLVERAGERVIHEDDG
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEECCCC
APAWRFPTPDALAACDLDKIGMPGKRVAALTGVARAVAAGDVPVDRAHADLAMLRSAWLE
CCCCCCCCCHHHHHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
LPGIGPWTVEYIAMRAWRDPDAWPASDLVLMQSIAARDPALDRLASQKHRTEGWRPWRAY
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHH
AALHLWNDVADRAGGARGG
HHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]