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The map label for this gene is lhgO [H]

Identifier: 116691066

GI number: 116691066

Start: 3362532

End: 3363641

Strand: Reverse

Name: lhgO [H]

Synonym: Bcen2424_3048

Alternate gene names: 116691066

Gene position: 3363641-3362532 (Counterclockwise)

Preceding gene: 116691067

Following gene: 116691065

Centisome position: 96.55

GC content: 71.17

Gene sequence:

>1110_bases
ATGGAGCAGACGGATTGTGTCGTGATCGGCGCGGGTGTCGTCGGTTTGGCGATTGCGCGCGAACTGGCCGCGCGCGGGCG
TGAAACGATCGTGCTCGAAGCGGCCGACGCGATCGGCACGGGCACGAGTTCGCGCAACAGTGAGGTGATTCACGCGGGGC
TCTACTATCCGCGCGGGTCGTTGAAGGCGACGTCGTGCGTGCACGGGCGCGACCTGCTGTACGAATTCTGCGACACGCAC
CACGTGCCGCACCGGCGCACGGGCAAGTTGCTGGTCGCGACGAGCGCCGCGCAGCTGAAGCAGTTGAAGGCGATCGCCGC
GCGCGCGGCCGAGAACGGCGTGCTCGACCTGCTGCCGCTCACGCGCGCCGAGGCGCAGACGCTCGAGCCCGCGCTCGAAT
GCGTGGAGGCGCTGTTCTCGCCGTCGACCGGCATCGTCGACAGCCACCAGCTGATGCTCGCGCTGCTCGGCGATGCGGAA
CGCGACGGCGCCGTGTGCGCGCTGCAATCTCCGGTCGAATCGATCGACGTGCTGGGCGGCGGGCGCTTCATCGTGCGCAC
CGGCGGCGCCGCGCCGACCGAGATCGACGCCGCGTGCGTGATCAACAGCGCGGGGCTCGGCGCGCAGGCGCTTGCGCGCC
GCACCCGCGGCCTCGATCCGCGCTGGGTGCCGCCGCTTTATCTCGCGCGCGGCAATTATTTCAGCCTGTCGGGGCGTGCG
CCGTTCTCGCACTTGATTTACCCGATGCCCGAGCGCGCGGGGCTCGGCGTGCACCTGACGTTCGATCTCGGCGGGCAGGC
GCGCTTCGGCCCGGACGTCGAGTGGTGCGATTCGCTGCGCTACGAAGTCGATCCGGCGCGCGCGGGTGCGTTCTACACGT
CGATCCGCGCGTTCTGGCCGGGCCTGCCCGACGATGCGCTGCAGCCGGCGTATGCGGGCATCCGGCCGAAGCTCGCGGGG
CCCGGCGAGCCGCCGGCCGACTTCATCGTGCAGGGCGCCGCGCAGCATGGCGTGCGCGGGCTCGTGAACCTGTTCGGCAT
CGAGTCGCCGGGGCTCACCGCGTCGCTCGCGCTTGCGCAGCGGGTAGGCGACATGGTGTCGCGCGCCTGA

Upstream 100 bases:

>100_bases
CCGTATCGCCGCGACGCGATGCGCACGCGTTCGGCAAGCGGGCGAACCGGGACGTACAATTCTTCTCTCCCCCATCGACG
CGCGAGCAGCGCGAAAAGCC

Downstream 100 bases:

>100_bases
CGCAACGGCCCGCCGCCGTGCGGGCCGGCCGCGCGAAACCCGTGTGGAATCCCTTATCTCCGGCATTTCGGCGCGCACAT
TTATTCGCTCGGGAGTTATT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MEQTDCVVIGAGVVGLAIARELAARGRETIVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKATSCVHGRDLLYEFCDTH
HVPHRRTGKLLVATSAAQLKQLKAIAARAAENGVLDLLPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAE
RDGAVCALQSPVESIDVLGGGRFIVRTGGAAPTEIDAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLIYPMPERAGLGVHLTFDLGGQARFGPDVEWCDSLRYEVDPARAGAFYTSIRAFWPGLPDDALQPAYAGIRPKLAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMVSRA

Sequences:

>Translated_369_residues
MEQTDCVVIGAGVVGLAIARELAARGRETIVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKATSCVHGRDLLYEFCDTH
HVPHRRTGKLLVATSAAQLKQLKAIAARAAENGVLDLLPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAE
RDGAVCALQSPVESIDVLGGGRFIVRTGGAAPTEIDAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLIYPMPERAGLGVHLTFDLGGQARFGPDVEWCDSLRYEVDPARAGAFYTSIRAFWPGLPDDALQPAYAGIRPKLAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMVSRA
>Mature_369_residues
MEQTDCVVIGAGVVGLAIARELAARGRETIVLEAADAIGTGTSSRNSEVIHAGLYYPRGSLKATSCVHGRDLLYEFCDTH
HVPHRRTGKLLVATSAAQLKQLKAIAARAAENGVLDLLPLTRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAE
RDGAVCALQSPVESIDVLGGGRFIVRTGGAAPTEIDAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
PFSHLIYPMPERAGLGVHLTFDLGGQARFGPDVEWCDSLRYEVDPARAGAFYTSIRAFWPGLPDDALQPAYAGIRPKLAG
PGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQRVGDMVSRA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=258, Percent_Identity=31.7829457364341, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI87082148, Length=339, Percent_Identity=29.7935103244838, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17565764, Length=324, Percent_Identity=34.8765432098765, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585081, Length=401, Percent_Identity=30.6733167082294, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38905; Mature: 38905

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTDCVVIGAGVVGLAIARELAARGRETIVLEAADAIGTGTSSRNSEVIHAGLYYPRGS
CCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKATSCVHGRDLLYEFCDTHHVPHRRTGKLLVATSAAQLKQLKAIAARAAENGVLDLLPL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEECC
TRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDGAVCALQSPVESIDVLGG
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCC
GRFIVRTGGAAPTEIDAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
CEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCC
PFSHLIYPMPERAGLGVHLTFDLGGQARFGPDVEWCDSLRYEVDPARAGAFYTSIRAFWP
CHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCCEECCHHHHHHHHHHHHHHCC
GLPDDALQPAYAGIRPKLAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQ
CCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RVGDMVSRA
HHHHHHHCC
>Mature Secondary Structure
MEQTDCVVIGAGVVGLAIARELAARGRETIVLEAADAIGTGTSSRNSEVIHAGLYYPRGS
CCCCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCCCCEEEEEEECCCCC
LKATSCVHGRDLLYEFCDTHHVPHRRTGKLLVATSAAQLKQLKAIAARAAENGVLDLLPL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCEEEECC
TRAEAQTLEPALECVEALFSPSTGIVDSHQLMLALLGDAERDGAVCALQSPVESIDVLGG
CHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCHHHHHHCCC
GRFIVRTGGAAPTEIDAACVINSAGLGAQALARRTRGLDPRWVPPLYLARGNYFSLSGRA
CEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCEEEECCCC
PFSHLIYPMPERAGLGVHLTFDLGGQARFGPDVEWCDSLRYEVDPARAGAFYTSIRAFWP
CHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHCCCEECCHHHHHHHHHHHHHHCC
GLPDDALQPAYAGIRPKLAGPGEPPADFIVQGAAQHGVRGLVNLFGIESPGLTASLALAQ
CCCCHHCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RVGDMVSRA
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]