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The map label for this gene is mug [H]

Identifier: 116690796

GI number: 116690796

Start: 3071458

End: 3071988

Strand: Reverse

Name: mug [H]

Synonym: Bcen2424_2776

Alternate gene names: 116690796

Gene position: 3071988-3071458 (Counterclockwise)

Preceding gene: 116690797

Following gene: 116690795

Centisome position: 88.18

GC content: 66.85

Gene sequence:

>531_bases
GTGGTTGACGCACTCCCCGACCTCATCGCGCCCCATCTTGACGTCCTGTTCTGCGGGATCAATCCCGGCCTGATCGCGGC
CGCGACCGGGCATCACTTCGCGGGAAGAAACAACCGCTTCTGGCGCGTGATCCATCTCGCGGGCTTCACGCCGACGGAAA
TTTCGCCGCGGGACGATCGCGAGATTCTCCGTTACGGCTGCGGGCTGACGGCCGTGGTGCCGCGGCCGACCGCCAGTGCC
GATCAGCTGTCGCGCGCGGAATTCGTGGCCGCGGCCGCCGGGTTCGAGCAGAAGGTCGCGCATCATGCGCCGCGCTTCGT
CGCGTTTCTCGGCAAGGCGGCGTATGCGGCGCTGTCGGGGCAACGGGAAGCCGCGTGGGGATTGCAGCCGTCCCCTATCC
AGCAGGCGCGGGTGTGGGTGCTCCCCAACCCCAGCGGCAGAAACCTTGCGTTCGGGCTCGACGATCTGGTCGATGCGTAT
CATGAGCTTCATCTCGCCGCGATGAAGGACCGGCACGATGCGACGCAGTAA

Upstream 100 bases:

>100_bases
GCGATGGGCCCGAATGTCCGAGTCAAGCCAGTCGCTTGGCCCGGGTTTTCGGGCCTCGTTTCGTTTACGTGGTTCCTGCA
CGCCGCACCCTGGGTGAACC

Downstream 100 bases:

>100_bases
GACGGCGGCGCCGTGGCCGGGCACCATCGTGCCGCGCGCGTTCTTCAACCGCATGGCCACCGAGGTGGCGCCGCAACTCC
TGAACAAGATCCTCGCGGCA

Product: uracil-DNA glycosylase superfamily protein

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MVDALPDLIAPHLDVLFCGINPGLIAAATGHHFAGRNNRFWRVIHLAGFTPTEISPRDDREILRYGCGLTAVVPRPTASA
DQLSRAEFVAAAAGFEQKVAHHAPRFVAFLGKAAYAALSGQREAAWGLQPSPIQQARVWVLPNPSGRNLAFGLDDLVDAY
HELHLAAMKDRHDATQ

Sequences:

>Translated_176_residues
MVDALPDLIAPHLDVLFCGINPGLIAAATGHHFAGRNNRFWRVIHLAGFTPTEISPRDDREILRYGCGLTAVVPRPTASA
DQLSRAEFVAAAAGFEQKVAHHAPRFVAFLGKAAYAALSGQREAAWGLQPSPIQQARVWVLPNPSGRNLAFGLDDLVDAY
HELHLAAMKDRHDATQ
>Mature_176_residues
MVDALPDLIAPHLDVLFCGINPGLIAAATGHHFAGRNNRFWRVIHLAGFTPTEISPRDDREILRYGCGLTAVVPRPTASA
DQLSRAEFVAAAAGFEQKVAHHAPRFVAFLGKAAYAALSGQREAAWGLQPSPIQQARVWVLPNPSGRNLAFGLDDLVDAY
HELHLAAMKDRHDATQ

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=160, Percent_Identity=33.125, Blast_Score=102, Evalue=2e-22,
Organism=Escherichia coli, GI1789449, Length=162, Percent_Identity=45.0617283950617, Blast_Score=145, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21356805, Length=145, Percent_Identity=35.1724137931034, Blast_Score=106, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 19105; Mature: 19105

Theoretical pI: Translated: 7.32; Mature: 7.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDALPDLIAPHLDVLFCGINPGLIAAATGHHFAGRNNRFWRVIHLAGFTPTEISPRDDR
CCCCCHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCHH
EILRYGCGLTAVVPRPTASADQLSRAEFVAAAAGFEQKVAHHAPRFVAFLGKAAYAALSG
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHCC
QREAAWGLQPSPIQQARVWVLPNPSGRNLAFGLDDLVDAYHELHLAAMKDRHDATQ
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVDALPDLIAPHLDVLFCGINPGLIAAATGHHFAGRNNRFWRVIHLAGFTPTEISPRDDR
CCCCCHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCCCCCCCCHH
EILRYGCGLTAVVPRPTASADQLSRAEFVAAAAGFEQKVAHHAPRFVAFLGKAAYAALSG
HHHHHCCCCEEECCCCCCCHHHHHHHHHHHHHHCHHHHHHHHCHHHHHHHHHHHHHHHCC
QREAAWGLQPSPIQQARVWVLPNPSGRNLAFGLDDLVDAYHELHLAAMKDRHDATQ
CCCCCCCCCCCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA