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The map label for this gene is strD [H]

Identifier: 116690733

GI number: 116690733

Start: 3005678

End: 3006400

Strand: Direct

Name: strD [H]

Synonym: Bcen2424_2713

Alternate gene names: 116690733

Gene position: 3005678-3006400 (Clockwise)

Preceding gene: 116690732

Following gene: 116690735

Centisome position: 86.27

GC content: 72.34

Gene sequence:

>723_bases
ATGAGCACTACCCTGACCACGGCGATGATCTTCGCCGCCGGACGCGGCGAGCGGATGCGTCCGCTGACCGACACCCGCCC
GAAACCGCTGCTCGAAGCCGGCGGCAAGCCGCTGATCGTCTGGCAGATCGAGGCGCTCGCGCGGGCGGGCATCGAGACGA
TCGTGATCAACCACGCGTGGCTCGGCGAGCAGATCGAGGCGGCGCTCGGCGACGGTTCGCGCTGGGGCGTGCGGCTCGCG
TATTCGGCCGAAGGCGACGCGCTGGAGACCGCGGGCGGCATCGCGCAGGCGCTGCCGCTCATCGAGCGTGATGGGCAGCC
GGCCGTGTTCGCGGCCGTCAGCGGCGACGTGTACTGCGCGTTCGACTACCGGACGCTCGCGCCGCGCGCCGCCCGGATGG
CCGCGCTCGACACGCCGGCGATGCACCTGGTGATGGTGCCGAACCCGCCGTTCCACCCGGCCGGCGACTTCGCGCTCGGC
GACGACGGTCGTCTGGCGCTCGACGGTGCCGCGCGCTTCACGTTCGGCAACATCGGCCTGTACGACACGCGGATGTTCCG
CGATCTCGCGCCCGGCACGCGGCGCGCGCTGACGCCGTACTATCGCGCGGCGATCGAAGCCGGCCACGCGAGCGGCGAAC
TGTACGAAGGCATCTGGGAGAACGTCGGCACGCCCGCGCAGCTCGGCGAACTCGACGCGCGACTGCGCGCCGCGGCAAGC
TGA

Upstream 100 bases:

>100_bases
CGCCCGCTCGTGCCGTTCGCGAAGCTGCTCGACGAGCTCGAGGGCAACGCACCGGCCGACGTCGGCTATACGTTCTGACC
GTCCTCACGTCCAGTCGAAC

Downstream 100 bases:

>100_bases
TCGTTTCGCGACTGACTGCCGGTTCCCCGGCGTGGCGGCCGATGGGCTGACAGGCCGGGGACGGCGCGCGGTCCACCAGC
CGCGAACCGTTCCGGAGCGA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLA
YSAEGDALETAGGIAQALPLIERDGQPAVFAAVSGDVYCAFDYRTLAPRAARMAALDTPAMHLVMVPNPPFHPAGDFALG
DDGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGHASGELYEGIWENVGTPAQLGELDARLRAAAS

Sequences:

>Translated_240_residues
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLA
YSAEGDALETAGGIAQALPLIERDGQPAVFAAVSGDVYCAFDYRTLAPRAARMAALDTPAMHLVMVPNPPFHPAGDFALG
DDGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGHASGELYEGIWENVGTPAQLGELDARLRAAAS
>Mature_239_residues
STTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAWLGEQIEAALGDGSRWGVRLAY
SAEGDALETAGGIAQALPLIERDGQPAVFAAVSGDVYCAFDYRTLAPRAARMAALDTPAMHLVMVPNPPFHPAGDFALGD
DGRLALDGAARFTFGNIGLYDTRMFRDLAPGTRRALTPYYRAAIEAGHASGELYEGIWENVGTPAQLGELDARLRAAAS

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=121, Percent_Identity=33.8842975206612, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI11761619, Length=121, Percent_Identity=33.8842975206612, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=121, Percent_Identity=39.6694214876033, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=120, Percent_Identity=38.3333333333333, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21355443, Length=123, Percent_Identity=36.5853658536585, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644084, Length=123, Percent_Identity=36.5853658536585, Blast_Score=84, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 25592; Mature: 25461

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAW
CCCHHEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHHHHHCCCEEEEEECCC
LGEQIEAALGDGSRWGVRLAYSAEGDALETAGGIAQALPLIERDGQPAVFAAVSGDVYCA
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCCCEEEEEECCCEEEE
FDYRTLAPRAARMAALDTPAMHLVMVPNPPFHPAGDFALGDDGRLALDGAARFTFGNIGL
ECCHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCEEEEECCCCC
YDTRMFRDLAPGTRRALTPYYRAAIEAGHASGELYEGIWENVGTPAQLGELDARLRAAAS
HHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STTLTTAMIFAAGRGERMRPLTDTRPKPLLEAGGKPLIVWQIEALARAGIETIVINHAW
CCHHEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEEEEHHHHHCCCEEEEEECCC
LGEQIEAALGDGSRWGVRLAYSAEGDALETAGGIAQALPLIERDGQPAVFAAVSGDVYCA
CCHHHHHHHCCCCCCCEEEEEECCCCCHHHHCHHHHHHHHHHCCCCCEEEEEECCCEEEE
FDYRTLAPRAARMAALDTPAMHLVMVPNPPFHPAGDFALGDDGRLALDGAARFTFGNIGL
ECCHHHCCHHHHHHHCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCEEEEECCCCC
YDTRMFRDLAPGTRRALTPYYRAAIEAGHASGELYEGIWENVGTPAQLGELDARLRAAAS
HHHHHHHHCCCCCHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]