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The map label for this gene is dmlR [H]

Identifier: 116690712

GI number: 116690712

Start: 2981040

End: 2982017

Strand: Direct

Name: dmlR [H]

Synonym: Bcen2424_2692

Alternate gene names: 116690712

Gene position: 2981040-2982017 (Clockwise)

Preceding gene: 116690707

Following gene: 116690713

Centisome position: 85.57

GC content: 67.38

Gene sequence:

>978_bases
TTGGCGTGGCATTTGAACCATTTTCAAAAATTTCTGGAAAATCGCATGGACCGACTGGGGGATATCCGGCTGTTCGTCGA
GGCGGCGGAACTGGGCAGCCTGTCCGCCGCCGGGCGCAAGCTGAACCTCACGCCGGCCGCCGCGAGCGCGCGGCTTGCAA
AACTCGAGGCGAAGATCGCGACGCGGCTGTTCGAGCGCTCGACGCGGCAATTGCGGCTCACCGACGAAGGCAAGCTGTAT
CTGAACTGCTGCCGCCAGGCGCTGCAGGCGCTCGACGACGCGGATGCGATGCTGCAGGAAGGCCGCAACGTCGTGAGCGG
CAAGGTGCGGCTGTCGTCGACGTCCGATTTCGGCCGCCACCAGCTGCTCGACTGGCTCCACGAATTCACGACGCTGCATC
CGGGCGTCACGTTCTCGCTGACGGCGTCCGATTCGTCGTCGAACCTGTGGCAGGACGAGATCGACCTCGCGATCCGCTTC
GCCGCGCCGCCCGACGGCGCGCTGATCGCCCGCCGGCTCGCGACCAACCGGCGCGTGCTGTGCGCGGCGCCGTCGTTCGT
CGAACGCCATGGCCTGCCGGCCGATCCGCACGATCTGGCCCGCTTTCCGTGCAACGTGATCACGATCGCATCCGGTCCGA
TGAACACCTGGCATTTCACGCGCGGCGACGAAGTGCAGATCCACACGGTGCCGGTGTCGACCGCGTTCGAGACCAACGAC
GGCGGCCTCACGCGCGAATGGACGCTGCGCGGCCACGGCATTGCACTGAAGTCGCTGTGGGACATCGCCGACGACGTCCG
CGCGGGCCGGCTGCGCGTGCTGCTGCCCGACTGGCGCCACCAGGACGCGCCGCTGCACGCGATCTATCACAGCAAGCGCT
ACATGGCGCCGCGCGTGCGCGTGCTGCTCGACTTTCTCGCCGAGCGCTTCGCGCGCGAGGAAGCCGCGCTCGACGACCTG
CTGAATGCGTGCCATTGA

Upstream 100 bases:

>100_bases
CGTTCTCCGGAAGGCGGCGGCCGCGGCGCCGGTTCGGTGCCGCACCGCACAAGAAAGCGGGATGTGCGCGCATTGTCCCG
AAGACGCCTATATTTGATAA

Downstream 100 bases:

>100_bases
TGGCCGCTCCTTAGGGGGGGTCGGAACCCCGGAGCCGGCGTCGCGCGCCCGCAACCGGCCGGCCGCCCGTCGTGGCACGA
AAAGCTATAATGGAAGGCTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MAWHLNHFQKFLENRMDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAKIATRLFERSTRQLRLTDEGKLY
LNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTSDFGRHQLLDWLHEFTTLHPGVTFSLTASDSSSNLWQDEIDLAIRF
AAPPDGALIARRLATNRRVLCAAPSFVERHGLPADPHDLARFPCNVITIASGPMNTWHFTRGDEVQIHTVPVSTAFETND
GGLTREWTLRGHGIALKSLWDIADDVRAGRLRVLLPDWRHQDAPLHAIYHSKRYMAPRVRVLLDFLAERFAREEAALDDL
LNACH

Sequences:

>Translated_325_residues
MAWHLNHFQKFLENRMDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAKIATRLFERSTRQLRLTDEGKLY
LNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTSDFGRHQLLDWLHEFTTLHPGVTFSLTASDSSSNLWQDEIDLAIRF
AAPPDGALIARRLATNRRVLCAAPSFVERHGLPADPHDLARFPCNVITIASGPMNTWHFTRGDEVQIHTVPVSTAFETND
GGLTREWTLRGHGIALKSLWDIADDVRAGRLRVLLPDWRHQDAPLHAIYHSKRYMAPRVRVLLDFLAERFAREEAALDDL
LNACH
>Mature_324_residues
AWHLNHFQKFLENRMDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAKIATRLFERSTRQLRLTDEGKLYL
NCCRQALQALDDADAMLQEGRNVVSGKVRLSSTSDFGRHQLLDWLHEFTTLHPGVTFSLTASDSSSNLWQDEIDLAIRFA
APPDGALIARRLATNRRVLCAAPSFVERHGLPADPHDLARFPCNVITIASGPMNTWHFTRGDEVQIHTVPVSTAFETNDG
GLTREWTLRGHGIALKSLWDIADDVRAGRLRVLLPDWRHQDAPLHAIYHSKRYMAPRVRVLLDFLAERFAREEAALDDLL
NACH

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=298, Percent_Identity=31.8791946308725, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1786401, Length=289, Percent_Identity=32.8719723183391, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789639, Length=296, Percent_Identity=28.3783783783784, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789440, Length=290, Percent_Identity=31.0344827586207, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI145693193, Length=294, Percent_Identity=30.2721088435374, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787128, Length=296, Percent_Identity=28.0405405405405, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786448, Length=188, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1788706, Length=175, Percent_Identity=29.1428571428571, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789173, Length=261, Percent_Identity=24.1379310344828, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI157672245, Length=165, Percent_Identity=28.4848484848485, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36510; Mature: 36379

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWHLNHFQKFLENRMDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAKIA
CCCCHHHHHHHHHHHHHHHCCEEEEEEHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHH
TRLFERSTRQLRLTDEGKLYLNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTSDFGRH
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCHHHHHHHCCCCEEECEEEECCCCCCHHH
QLLDWLHEFTTLHPGVTFSLTASDSSSNLWQDEIDLAIRFAAPPDGALIARRLATNRRVL
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEE
CAAPSFVERHGLPADPHDLARFPCNVITIASGPMNTWHFTRGDEVQIHTVPVSTAFETND
EECCHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEEECEEEEECCC
GGLTREWTLRGHGIALKSLWDIADDVRAGRLRVLLPDWRHQDAPLHAIYHSKRYMAPRVR
CCCEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCHHCCHHHH
VLLDFLAERFAREEAALDDLLNACH
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AWHLNHFQKFLENRMDRLGDIRLFVEAAELGSLSAAGRKLNLTPAAASARLAKLEAKIA
CCCHHHHHHHHHHHHHHHCCEEEEEEHHHHCCHHHCCCEEECCCHHHHHHHHHHHHHHH
TRLFERSTRQLRLTDEGKLYLNCCRQALQALDDADAMLQEGRNVVSGKVRLSSTSDFGRH
HHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCHHHHHHHCCCCEEECEEEECCCCCCHHH
QLLDWLHEFTTLHPGVTFSLTASDSSSNLWQDEIDLAIRFAAPPDGALIARRLATNRRVL
HHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCEEE
CAAPSFVERHGLPADPHDLARFPCNVITIASGPMNTWHFTRGDEVQIHTVPVSTAFETND
EECCHHHHHCCCCCCHHHHHHCCCCEEEEECCCCCCCEECCCCEEEEEEEECEEEEECCC
GGLTREWTLRGHGIALKSLWDIADDVRAGRLRVLLPDWRHQDAPLHAIYHSKRYMAPRVR
CCCEEEEEECCCCEEHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHCCHHCCHHHH
VLLDFLAERFAREEAALDDLLNACH
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]